Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation

Autor: Suzanne A. B. M. Aarts, Tom T. P. Seijkens, Pascal J. H. Kusters, Susanne M. A. van der Pol, Barbara Zarzycka, Priscilla D. A. M. Heijnen, Linda Beckers, Myrthe den Toom, Marion J. J. Gijbels, Louis Boon, Christian Weber, Helga E. de Vries, Gerry A. F. Nicolaes, Christine D. Dijkstra, Gijs Kooij, Esther Lutgens

Publikováno v: Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)

Abstract Background The influx of leukocytes into the central nervous system (CNS) is a key hallmark of the chronic neuro-inflammatory disease multiple sclerosis (MS). Strategies that aim to inhibit leukocyte migration across the blood-brain barrier

Externí odkaz: https://doaj.org/article/3098d45e563e46008b1ee78f986c3e30

Magnetic Resonance Imaging of Monocytes Labeled with Ultrasmall Superparamagnetic Particles of Iron Oxide Using Magnetoelectroporation in an Animal Model of Multiple Sclerosis

Autor: Raoul D. Oude Engberink, Susanne M.A. van der Pol, Pjotr Walczak, Annette van der Toorn, Max A. Viergever, Christine D. Dijkstra, Jeff W.M. Bulte, Helga E. de Vries, Erwin L.A. Blezer

Publikováno v: Molecular Imaging, Vol 9 (2010)

Infiltrated monocytes play a crucial role in the demyelination process during multiple sclerosis (MS), an inflammatory disease of the central nervous system (CNS). Still, methods to monitor their infiltration pattern over time are lacking. In this st

Externí odkaz: https://doaj.org/article/cd4002068b7c4658b69d332e14289ba0

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization

Autor: Margaret L. Hibbs, Michael Buchert, Matthias Ernst, Frederick Masson, Alex Boussioutas, Nima Etemadi, Moritz F. Eissmann, Jamina Brunnberg, Ashleigh R Poh, Toby J. Phesse, Robert J.J. O'Donoghue, Evelyn Tsantikos, Stefan Thiem, Andrew G. Jarnicki, Nicholas D. Huntington, Christine D. Dijkstra, Michele A. Grimbaldeston

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.2735. ⟨10.1038/s41467-019-10676-1⟩
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)

The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess the impact of tumor-adjacent, submucosal mast cell accumulation in murine and human intestinal-type gastric cancer. We fin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c1e3f5595a2c3eee8480a71492f5e79
http://europepmc.org/articles/PMC6588585

Abstract PO-014: DNA methyltransferases drive gastric cancer growth and present a therapy target for gastric cancer

Autor: Moritz F. Eissmann, Matthias Ernst, Anne Huber, Christine D. Dijkstra

Publikováno v: Cancer Research. 80:PO-014

Gastric cancer (GC) remains the third leading cause of cancer related death worldwide. While inflammation is a well-established driver of gastric tumorigenesis, only a small subset of GC patients responds to immunotherapy. The understanding of the tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f7772cac665aea0f2cebccf3eb9d0a4f
https://doi.org/10.1158/1538-7445.epimetab20-po-014

Interleukin 33: A new target against gastrointestinal cancer?

Autor: Matthias Ernst, Christine D. Dijkstra, Moritz F. Eissmann

Publikováno v: European Journal of Cancer. 138:S60

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd975acf077c553b93d078b658ae9936
https://doi.org/10.1016/s0959-8049(20)31239-9