Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christine D Pozniak"'
Autor:
Robert Mintzer, Sreemathy Ramaswamy, Kinjalkumar Shah, Rami N Hannoush, Christine D Pozniak, Frederick Cohen, Xianrui Zhao, Emile Plise, Joseph W Lewcock, Christopher E Heise
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30376 (2012)
Caspase-6 is a cysteinyl protease implicated in neurodegenerative conditions including Alzheimer's and Huntington's disease making it an attractive target for therapeutic intervention. A greater understanding of the role of caspase-6 in disease has b
Externí odkaz:
https://doaj.org/article/de49ec19875a41d9aa52b7a1c4028046
Autor:
Christine D. Pozniak, Abraham J. Langseth, Zena Werb, Samuel J. Pleasure, Gerrit J. P. Dijkgraaf, Youngshik Choe
Publikováno v:
Proceedings of the National Academy of Sciences. 107:21795-21800
Oligodendrocyte precursor cells (OPCs) are lineage-restricted progenitors generally limited in vivo to producing oligodendrocytes. Mechanisms controlling genesis of OPCs are of interest because of their importance in myelin development and their pote
Autor:
Christine D. Pozniak, Trung Huynh, Samuel J. Pleasure, Abraham J. Langseth, Roeben N. Munji, Youngshik Choe
Publikováno v:
The Journal of Neuroscience. 30:13367-13372
Oligodendrocyte precursor cells (OPCs) are generated from multiple progenitor domains in the telencephalon in developmental succession from ventral to dorsal. Previous studies showed that Wnt signaling inhibits the differentiation of OPCs into mature
Autor:
Vladimir V. Rymar, Freda D. Miller, Christine D. Pozniak, Fanie Barnabé-Heider, Anna F. Lee, Abbas F. Sadikot
Publikováno v:
The Journal of Neuroscience. 22:9800-9809
Here, we show that the p53 family member, p73, is necessary for survival and long-term maintenance of CNS neurons, including postnatal cortical neurons. In p73-/- animals, cortical neuron number is normal at birth but decreases significantly by postn
Autor:
Christine D. Pozniak, Marta Majdan, Shernaz X. Bamji, Carrie G. Causing, Daniel J. Belliveau, Judi Kohn, Raquel Aloyz, Freda D. Miller
Publikováno v:
The Journal of Cell Biology
To determine whether the p75 neurotrophin receptor (p75NTR) plays a role in naturally occurring neuronal death, we examined neonatal sympathetic neurons that express both the TrkA tyrosine kinase receptor and p75NTR. When sympathetic neuron survival
Autor:
Jasvinder K. Atwal, Christine D. Pozniak, Jean G. Toma, David L. Kaplan, Raquel Aloyz, Freda D. Miller, Shernaz X. Bamji
Publikováno v:
The Journal of Cell Biology
Naturally occurring sympathetic neuron death is the result of two apoptotic signaling events: one normally suppressed by NGF/TrkA survival signals, and a second activated by the p75 neurotrophin receptor. Here we demonstrate that the p53 tumor suppre
Autor:
Daniel J. Belliveau, Dmitri A. Rusakov, Freda D. Miller, Irena Krivko, Christine D. Pozniak, Judi Kohn, David L. Kaplan, Christian Lachance
Publikováno v:
The Journal of Cell Biology
In this report we examine the biological and molecular basis of the control of sympathetic neuron differentiation and survival by NGF and neurotrophin-3 (NT-3). NT-3 is as efficient as NGF in mediating neuritogenesis and expression of growth-associat
Autor:
Christine D. Pozniak, Jean G. Toma, Audrey Speelman, James Fabian, Eddie Chang, Freda D. Miller, T.C. Mathew
Publikováno v:
Developmental Biology. 161:206-217
Exposure of neuronal terminals to target-derived NGF has been hypothesized to regulate cell body responses at a distance. To test this hypothesis and, more specifically, to determine whether NGF distally regulates the synthesis of its two characteriz
Publikováno v:
Genome Biology
Quantitative trait locus analysis of two inbred mouse strains has revealed that cell survival is most highly correlated with neurogenesis.
Adult neurogenesis in the hippocampus is under complex genetic control. A recent comparative study of two
Adult neurogenesis in the hippocampus is under complex genetic control. A recent comparative study of two
Publikováno v:
Science's STKE. 2006
It is now widely accepted that discrete regions of the adult brain contain stem cells that continue to generate new neurons. However, it remains unclear what molecular signals define the neurogenic niche and how such signals act on the heterogeneous