Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christine Cirl"'
Autor:
Anna Waldhuber, Greg A. Snyder, Franziska Römmler, Christine Cirl, Tina Müller, Tsan Sam Xiao, Catharina Svanborg, Thomas Miethke
Publikováno v:
Pathogens, Vol 5, Iss 1, p 25 (2016)
The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus
Externí odkaz:
https://doaj.org/article/3910b074a62c46d19ad0e019b57dc0b9
Autor:
Nina Wantia, Nuria Rodriguez, Christine Cirl, Tanja Ertl, Susanne Dürr, Laura E Layland, Hermann Wagner, Thomas Miethke
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26101 (2011)
TLR2 and TLR4 are crucial for recognition of Chlamydia pneumoniae in vivo, since infected TLR2/4 double-deficient mice are unable to control the infection as evidenced by severe loss of body weight and progressive lethal pneumonia. Unexpectedly, thes
Externí odkaz:
https://doaj.org/article/c3d48e760e044a39be0abb8321f56b9a
Autor:
Manisha Yadav, Jingyao Zhang, Hans Fischer, Wen Huang, Nataliya Lutay, Christine Cirl, Josephine Lum, Thomas Miethke, Catharina Svanborg
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001120 (2010)
Toll-like receptor signaling requires functional Toll/interleukin-1 (IL-1) receptor (TIR) domains to activate innate immunity. By producing TIR homologous proteins, microbes inhibit host response induction and improve their own survival. The TIR homo
Externí odkaz:
https://doaj.org/article/482856aed9ea470e86324c871fb9f310
Autor:
Yunji Zheng, Andreas Wieser, Anna Waldhuber, Catharina Svanborg, Silke Neumann-Pfeifer, Simone Albrecht, Franziska Römmler, Sören Schubert, Manoj Puthia, Christine Cirl, Tina Müller, Olaf Groß, Susanne Dürr, Thomas Miethke
Publikováno v:
Journal of Clinical Investigation. 126:2425-2436
Successful bacterial pathogens produce an array of virulence factors that allow subversion of the immune system and persistence within the host. For example, uropathogenic Escherichia coli strains, such as CFT073, express Toll/IL-1 receptor-containin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14b820506cd8f879ed2630d8ba73fe0
https://doi.org/10.1172/jci81916
https://doi.org/10.1172/jci81916
Autor:
Nico Tjandra, Greg A. Snyder, Kang Chen, Susanne Dürr, Franziska Römmler, Tsan Sam Xiao, Nathaniel W. Snyder, Jiansheng Jiang, Christine Cirl, Thomas Miethke, Patrick F. Smith, Anna Waldhuber, Theresa Fresquez
Publikováno v:
Proceedings of the National Academy of Sciences. 110:6985-6990
The Toll/IL-1 receptor (TIR) domains are crucial signaling modules during innate immune responses involving the Toll-like receptors (TLRs) and IL-1 receptor (IL-1R). Myeloid differential factor 88 (MyD88) is a central TIR domain-containing adapter mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fe8dceb867bff053c2cc964f8a9aa7e
https://doi.org/10.1073/pnas.1215770110
https://doi.org/10.1073/pnas.1215770110
Autor:
Greg A. Snyder, Tina Müller, Tsan Sam Xiao, Thomas Miethke, Franziska Römmler, Catharina Svanborg, Christine Cirl, Anna Waldhuber
Publikováno v:
Pathogens, Vol 5, Iss 1, p 25 (2016)
Pathogens
Pathogens; 5(25), pp 1-8 (2016)
Pathogens
Pathogens; 5(25), pp 1-8 (2016)
The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a8297189de9c851ce0f864a9604dcb
http://www.mdpi.com/2076-0817/5/1/25
http://www.mdpi.com/2076-0817/5/1/25
Autor:
Nina Wantia, Nuria Rodriguez, Thomas Miethke, Georg Peschel, Christine Cirl, Hermann Wagner, Tanja Ertl, Lavinia Kernschmidt, Susanne Dürr
Publikováno v:
Molecular Microbiology. 76:648-661
Chlamydophila pneumoniae was shown to prevent IFN gamma-inducible upregulation of MHC-class II molecules by secreting chlamydial protease-like activity factor (CPAF) into the cytosol of those host cells which support the complete bacterial replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dba727dc6c11d5c84b49165bd76c3b82
https://doi.org/10.1111/j.1365-2958.2010.07114.x
https://doi.org/10.1111/j.1365-2958.2010.07114.x
Autor:
Nuria Rodriguez, Andreas Wieser, Dominik Stappert, Christine Cirl, Nina Wantia, Hermann Wagner, Susanne Duerr, Manisha Yadav, Sören Schubert, Hans Fischer, Catharina Svanborg, Thomas Miethke
Publikováno v:
Nature Medicine. 14:399-406
Pathogenic microbes have evolved sophisticated molecular strategies to subvert host defenses. Here we show that virulent bacteria interfere directly with Toll-like receptor (TLR) function by secreting inhibitory homologs of the Toll/interleukin-1 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e55b380c9594e8b51497051e03e919
https://doi.org/10.1038/nm1734
https://doi.org/10.1038/nm1734
Autor:
Jiansheng Jiang, Eric J. Sundberg, Daniel Deredge, Timothy Luchetti, Patrick T. Smith, William H. Jennings, Susi Durr, Christine Cirl, Nathaniel W. Snyder, Theresa Fresquez, Patrick L. Wintrode, David Z. Wilkins, Greg A. Snyder, Thomas Miethke, Anna Waldhuber, T. Sam Xiao
Publikováno v:
The Journal of biological chemistry. 289(2)
The Toll/IL-1 receptor (TIR) domains are crucial innate immune signaling modules. Microbial TIR domain-containing proteins inhibit Toll-like receptor (TLR) signaling through molecular mimicry. The TIR domain-containing protein TcpB from Brucella inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbe85ca5bbdce999e57d48f12c6bf30
https://pubmed.ncbi.nlm.nih.gov/24275656
https://pubmed.ncbi.nlm.nih.gov/24275656
Autor:
Nuria Rodriguez, Christine Cirl, Susanne Dürr, Laura E. Layland, Hermann Wagner, Thomas Miethke, Nina Wantia, Tanja Ertl
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e26101 (2011)
PLoS ONE
PLoS ONE
TLR2 and TLR4 are crucial for recognition of Chlamydia pneumoniae in vivo, since infected TLR2/4 double-deficient mice are unable to control the infection as evidenced by severe loss of body weight and progressive lethal pneumonia. Unexpectedly, thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10f69790c55a808ef287045bf0a4054e
http://europepmc.org/articles/PMC3212512?pdf=render
http://europepmc.org/articles/PMC3212512?pdf=render