Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christine Charon"'
Autor:
Micheline Kergoat, François Giuliano, Annick M. Audet, Delphine Behr-Roussel, Christine Charon, Stephanie Oger-Roussel, Stéphanie Caisey, Jacques Bernabé, Laurent Alexandre
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 306:R108-R117
Despite the fact that urogenito-sexual complications significantly impact the quality of life of diabetic patients, a robust in vivo experimental model is lacking. Bladder and erectile function in the Type 2 diabetic Goto-Kakizaki (GK) rat and respon
Autor:
Fabien Schmidlin, Sophie Bozec, Franck F. Lepifre, Denis Carniato, Serge Christmann-Franck, Eric Valeur, Caroline Leriche, Didier Roche, Marc Lecomte, Liliane Doare, Christine Charon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3682-3685
Spiro-carboxamides were identified as inhibitors of 11β-hydroxysteroid-dehydrogenase type 1 by high-throughput screening. Structure-based drug design was used to optimise the initial hit yielding a sub-nanomolar IC50 inhibitor (0.5 nM) on human 11β
Autor:
Eric Valeur, Marc Lecomte, Christine Charon, Caroline Leriche, Franck F. Lepifre, Liliane Doare, Fabien Schmidlin, Denis Carniato, Serge Christmann-Franck, Didier Roche, Ulrich Graedler, Sophie Bozec
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2674-2678
Benzylamides of pentanedioic acid were identified as inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) by high-throughput screening. Optimisation to 2-adamantyl amides yielded inhibitors with single digit nanomolar IC(50)s on the
Autor:
Vincent C. Manganiello, Gérard Mory, Narcisse Komas, Christine Charon, Carole Coudray, R Bazin, F Diot-Dupuy, Pascal Ferré
Publikováno v:
FEBS Letters. 456:207-210
The present study was undertaken to characterise the phosphodiesterases (PDEs) present in brown adipose tissue (BAT) of Zucker rat pups and to determine whether the capacity for degradation of cyclic nucleotides was affected by the fatty genotype. Re
Autor:
Jacques Pairault, Annie Quignard-Boulangé, Sylvie Hauguel-de Mouzon, Christine Charon, Khadija El Hadri, Bruno Fève
Publikováno v:
Biochemical Journal. 323:359-364
The beta3-adrenergic receptor (beta3-AR) exerts a central role in the transduction of catecholamine effects in white and brown adipose tissue (WAT and BAT). A recent report has documented that insulin strongly down-regulates beta3-AR expression and c
Autor:
Per Hillertz, Eric Valeur, Christine Charon, Didier Roche, Serge Christmann-Franck, Djordje Musil, Denis Carniato, Liliane Doare, Sophie Bozec, Fabien Schmidlin, Melanie Schultz, Cravo Daniel, Franck F. Lepifre, Marc Lecomte
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(18)
Indole-pyrrolidines were identified as inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by high-throughput screening. Optimisation of the initial hit through structure-based design led to 7-azaindole-derivatives, with the best analo
This study was undertaken to determine whether receptor and non-receptor components of the adenylate cyclase (AC) cascade were altered in brown adipose tissue (BAT) of 14-day-old pre-obese (fa/fa) rats, before endocrine status is strongly modified by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daa302115fe7bc6a426e023969201070
https://europepmc.org/articles/PMC1136182/
https://europepmc.org/articles/PMC1136182/