An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury

Autor: Amanda Brosius Lutz, Tawaun A. Lucas, Glenn A. Carson, Christine Caneda, Lu Zhou, Ben A. Barres, Marion S. Buckwalter, Steven A. Sloan

Publikováno v: Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-15 (2022)

Abstract Background The important contribution of glia to mechanisms of injury and repair of the nervous system is increasingly recognized. In stark contrast to the central nervous system (CNS), the peripheral nervous system (PNS) has a remarkable ca

Externí odkaz: https://doaj.org/article/f76f22d3e17d4948b45984c355586a61

Single-Cell RNA-Seq Analysis of Infiltrating Neoplastic Cells at the Migrating Front of Human Glioblastoma

Autor: Spyros Darmanis, Steven A. Sloan, Derek Croote, Marco Mignardi, Sophia Chernikova, Peyman Samghababi, Ye Zhang, Norma Neff, Mark Kowarsky, Christine Caneda, Gordon Li, Steven D. Chang, Ian David Connolly, Yingmei Li, Ben A. Barres, Melanie Hayden Gephart, Stephen R. Quake

Publikováno v: Cell Reports, Vol 21, Iss 5, Pp 1399-1410 (2017)

Summary: Glioblastoma (GBM) is the most common primary brain cancer in adults and is notoriously difficult to treat because of its diffuse nature. We performed single-cell RNA sequencing (RNA-seq) on 3,589 cells in a cohort of four patients. We obtai

Externí odkaz: https://doaj.org/article/bf12d57bf0314dcea53a803c49777459

An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury

Autor: Amanda Brosius Lutz, Tawaun A. Lucas, Glenn A. Carson, Christine Caneda, Lu Zhou, Ben A. Barres, Marion S. Buckwalter, Steven A. Sloan

Publikováno v: Brosius Lutz, Amanda; Lucas, Tawaun A; Carson, Glenn A; Caneda, Christine; Zhou, Lu; Barres, Ben A; Buckwalter, Marion S; Sloan, Steven A (2022). An RNA-sequencing transcriptome of the rodent Schwann cell response to peripheral nerve injury. Journal of neuroinflammation, 19(1), p. 105. BioMed Central 10.1186/s12974-022-02462-6

Background The important contribution of glia to mechanisms of injury and repair of the nervous system is increasingly recognized. In stark contrast to the central nervous system (CNS), the peripheral nervous system (PNS) has a remarkable capacity fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5a3e15bb05d9ea65458a03df75162f
https://pubmed.ncbi.nlm.nih.gov/35501870

Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection

Autor: Jiannis Taxidis, Jessie E. Buth, Ren Sun, Xinghong Dai, Eric J. Huang, Simone Liebscher, Ye Zhang, Katja Schenke-Layland, Giovanni Coppola, Caroline A. Pearson, Luis de la Torre-Ubieta, Bennett G. Novitch, Christine Caneda, Momoko Watanabe, Danyang Gong, Genhong Cheng, Daniel H. Geschwind, Roghiyh Aliyari, Peyman Golshani, Neda Vishlaghi, Ken Yamauchi, Robert Damoiseaux, Baljit S. Khakh

Publikováno v: Cell Reports, Vol 21, Iss 2, Pp 517-532 (2017)
Cell reports, vol 21, iss 2
Watanabe, M; Buth, JE; Vishlaghi, N; de la Torre-Ubieta, L; Taxidis, J; Khakh, BS; et al.(2017). Self-Organized Cerebral Organoids with Human-Specific Features Predict Effective Drugs to Combat Zika Virus Infection. CELL REPORTS, 21(2), 517-532. doi: 10.1016/j.celrep.2017.09.047. UCLA: Retrieved from: http://www.escholarship.org/uc/item/0ht3q9ms

Summary: The human cerebral cortex possesses distinct structural and functional features that are not found in the lower species traditionally used to model brain development and disease. Accordingly, considerable attention has been placed on the dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ac5a76fb8c7cc751780afb8cbf7f87
http://www.sciencedirect.com/science/article/pii/S2211124717313372

A survey of human brain transcriptome diversity at the single cell level

Autor: Lawrence M. Shuer, Martin Enge, Melanie Hayden Gephart, Christine Caneda, Stephen R. Quake, Ye Zhang, Ben A. Barres, Spyros Darmanis, Steven A. Sloan

Publikováno v: Proceedings of the National Academy of Sciences. 112:7285-7290

The human brain is a tissue of vast complexity in terms of the cell types it comprises. Conventional approaches to classifying cell types in the human brain at single cell resolution have been limited to exploring relatively few markers and therefore

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0445407c01a0a47b9e58d54f5a540d51
https://doi.org/10.1073/pnas.1507125112