Inhibition of the SR protein-phosphorylating CLK kinases of Plasmodium falciparum impairs blood stage replication and malaria transmission.

Autor: Selina Kern, Shruti Agarwal, Kilian Huber, André P Gehring, Benjamin Strödke, Christine C Wirth, Thomas Brügl, Liliane Onambele Abodo, Thomas Dandekar, Christian Doerig, Rainer Fischer, Andrew B Tobin, Mahmood M Alam, Franz Bracher, Gabriele Pradel

Publikováno v: PLoS ONE, Vol 9, Iss 9, p e105732 (2014)

Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate Serine/Arginine-rich (SR) proteins involved in pre-mRNA processing. Four CLKs, termed PfCLK-1-4, can be identified in the human malaria parasite Plasm

Externí odkaz: https://doaj.org/article/e398157699dd49e6be108736c544d6ca

Perforin-like protein PPLP2 permeabilizes the red blood cell membrane during egress of Plasmodium falciparum gametocytes

Autor: Swati Garg, Urska Repnik, Gareth Griffiths, Matthias Scheuermayer, Rainer Fischer, Marika M. Kachman, Dominik Schaack, Tim Weißbach, Chetan E. Chitnis, Shailja Singh, Thomas Dandekar, Christine C. Wirth, Svetlana Glushakova, Gabriele Pradel, Joshua Zimmerberg

Publikováno v: Cellular Microbiology

Egress of malaria parasites from the host cell requires the concerted rupture of its enveloping membranes. Hence, we investigated the role of the plasmodial perforin-like protein PPLP2 in the egress of Plasmodium falciparum from erythrocytes. PPLP2 i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab5b35212b150a5cd50df9776de15e27
http://europepmc.org/articles/PMC4312913

Inhibition of the SR Protein-Phosphorylating CLK Kinases of Plasmodium falciparum Impairs Blood Stage Replication and Malaria Transmission

Autor: Gabriele Pradel, Mahmood M. Alam, Rainer Fischer, Liliane Onambele Abodo, Thomas Brügl, Thomas Dandekar, Benjamin Strödke, Christine C. Wirth, Selina Kern, Franz Bracher, Shruti Agarwal, André P. Gehring, Andrew B. Tobin, Kilian Huber, Christian Doerig

Publikováno v: PLoS ONE
PLoS ONE, Vol 9, Iss 9, p e105732 (2014)

Cyclin-dependent kinase-like kinases (CLKs) are dual specificity protein kinases that phosphorylate Serine/Arginine-rich (SR) proteins involved in pre-mRNA processing. Four CLKs, termed PfCLK-1-4, can be identified in the human malaria parasite Plasm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f41dccc2452d4da363e4cfa5d02a6c
https://publica.fraunhofer.de/handle/publica/238848

Molecular mechanisms of host cell egress by malaria parasites

Autor: Gabriele Pradel, Christine C. Wirth

Publikováno v: International journal of medical microbiology : IJMM. 302(4-5)

Egress is a crucial step for malaria parasites to progress from one host cell to another. The rapid transition between host cells is mediated by the invasive merozoite stages. Merozoite egress from the enveloping cell includes the rupture of two memb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32c05dfba255e7d4fa120abb11e9db0c
https://pubmed.ncbi.nlm.nih.gov/22951233

Triage Decisions in the Context of COVID-19: Old Burden, New Challenge-The Structured Approach for Intensive Care Unit Triage (SAINT) Protocol.

Autor: Jänig C; Role 2E, MN MedCoy TAAC N, Mazar-e-Sharif, Afghanistan.; Department for Anesthesiology and Intensive Care Medicine, Bundeswehr Central Hospital, 56072 Koblenz, Germany., Forklage R; Role 2E, MN MedCoy TAAC N, Mazar-e-Sharif, Afghanistan.; Department for Anesthesiology, Pain Medicine and Palliative Care, Elisabeth-TweeSteden Ziekenhuis, 5042 AD Tilburg, The Netherlands., Gurney JM; NATO Role 2E Commander, Kabul, Afghanistan.; Department for Trauma Surgery, RadboudUMC, Nijmegen, 6525 GA, The Netherlands., Groth R; Role 2E, MN MedCoy TAAC N, Mazar-e-Sharif, Afghanistan.; Department for Anesthesiology and Intensive Care Medicine, Bundeswehr Central Hospital, 56072 Koblenz, Germany., Wirth C; Role 2E, MN MedCoy TAAC N, Mazar-e-Sharif, Afghanistan.; Department for Anesthesiology and Intensive Care Medicine, Bundeswehr Central Hospital, 56072 Koblenz, Germany., van de Krol H; Role 2E, MN MedCoy TAAC N, Mazar-e-Sharif, Afghanistan.; Department for Trauma Surgery, RadboudUMC, Nijmegen, 6525 GA, The Netherlands., Schmidbauer W; Department for Anesthesiology and Intensive Care Medicine, Bundeswehr Central Hospital, 56072 Koblenz, Germany., Güsgen C; Role 2E, MN MedCoy TAAC N, Mazar-e-Sharif, Afghanistan.; Department for General, Visceral and Thoracic Surgery, Bundeswehr Central Hospital, 56072 Koblenz, Germany.; Joint Trauma System, San Antonio, Texas, 78234, USA.

Publikováno v: Military medicine [Mil Med] 2021 Feb 26; Vol. 186 (3-4), pp. e300-e304.