Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christine C. Vinluan"'
Autor:
Gary M. Coppola, Xilin Liu, Robert C. Anderson, Douglas C. Knorr, William S. Fillers, James L. Stanton, Jiaping Gao, Tomaselli Hc, Christine C. Vinluan, Thomas Daniel Aicher, Carol J. Dragland, Suraj S. Shetty, Wieslawa Maniara, A. Islam, Emma L. Kaplan, William R. Mann, Leonard J. Brand, Donald Mark Sperbeck, R. E. Walter, Dominick DelGrande, R. J. Lozito
Publikováno v:
Journal of Medicinal Chemistry. 43:236-249
N‘-Methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC50 = 180 μM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a21921472d2095e7c5eea09d6d92805
https://doi.org/10.1021/jm990358+
https://doi.org/10.1021/jm990358+
Autor:
Emma L. Kaplan, Jiaping Gao, Leonard J. Brand, Robert E. Damon, Judit Koletar, Christine C. Vinluan, Suraj S. Shetty, Thomas Daniel Aicher, William R. Mann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2223-2228
Several oximes of triterpenes with a 17-beta hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7845fb3e46576be1780877fa834d49f
https://doi.org/10.1016/s0960-894x(99)00380-7
https://doi.org/10.1016/s0960-894x(99)00380-7
Autor:
Emma L. Kaplan, Gary M. Coppola, Xilin Liu, Gregory Raymond Bebernitz, Donald Mark Sperbeck, Dominick DelGrande, Wieslawa Maniara, Leonard J. Brand, Suraj S. Shetty, Thomas Daniel Aicher, Robert C. Anderson, Charles F. Jewell, R. J. Lozito, Douglas C. Knorr, A. Islam, Chen Liu, Christine C. Vinluan, Jianping Gao, Robert J. Strohschein, William R. Mann, Carol J. Dragland, R. E. Walter
Publikováno v:
Journal of Medicinal Chemistry. 42:2741-2746
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b80d109ec966714cd20d37ebc973dd61
https://doi.org/10.1021/jm9902584
https://doi.org/10.1021/jm9902584
Autor:
Bing Yan, Sid Topiol, Thomas Daniel Aicher, Carol J. Dragland, Vijayayakumar Sundararajan, John C. Jackson, William R. Mann, John E. Blume, Philip A. Bell, Paul Ramage, Christine C. Vinluan, John S. Gounarides, N. R. Nirmala
Publikováno v:
Biochemical Journal. 334:703-711
The activity of the pyruvate dehydrogenase multienzyme complex (PDC), which catalyses the oxidation of pyruvate to acetyl-CoA within the mitochondrion, is diminished in animal models of diabetes. Studies with purified PDC components have suggested th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::405c028ae9929d1cb5f403e9247ed185
https://doi.org/10.1042/bj3340703
https://doi.org/10.1042/bj3340703
Autor:
Emma L. Kaplan, William R. Mann, Suraj S. Shetty, Christine C. Vinluan, Judit Koletar, Robert E. Damon, Jiaping Gao, Leonard J. Brand, Thomas Daniel Aicher
Publikováno v:
ChemInform. 30
Several oximes of triterpenes with a 17-β hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bffb978b3fe8103e27196390eda837ac
https://doi.org/10.1002/chin.199945217
https://doi.org/10.1002/chin.199945217
Autor:
Carol J. Dragland, William R. Mann, Philip A. Bell, T.R Vedananda, Thomas Daniel Aicher, Christine C. Vinluan
Publikováno v:
Biochimica et biophysica acta. 1480(1-2)
The mechanism of action of structurally distinct pyruvate dehydrogenase kinase (PDK) inhibitors was examined in assays with experimental contexts ranging from an intact pyruvate dehydrogenase complex (PDC) with and without supplemental ATP or ADP to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409b5e166d22171d1c1e527822433cb6
https://pubmed.ncbi.nlm.nih.gov/11004568
https://pubmed.ncbi.nlm.nih.gov/11004568
Autor:
Wei H. Wang, Christine C. Vinluan, Robert J. Strohschein, Xilin Liu, Emma L. Kaplan, Dominick DelGrande, Gregory Raymond Bebernitz, Douglas C. Knorr, Jennifer Tan, Jiaping Gao, Suraj S. Shetty, James L. Stanton, Charles Liu, Thomas Daniel Aicher, Carol J. Dragland, William R. Mann, Leonard J. Brand, Robert J. Lozito, Wieslawa Maniara, Amin Islam
Publikováno v:
Journal of medicinal chemistry. 43(11)
The optimization of a series of anilide derivatives of (R)-3,3, 3-trifluoro-2-hydroxy-2-methylpropionic acid as inhibitors of pyruvate dehydrogenase kinase (PDHK) is described that started from N-phenyl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9230c1ef002859de18c4f7fe1f8ef950
https://pubmed.ncbi.nlm.nih.gov/10841803
https://pubmed.ncbi.nlm.nih.gov/10841803
Autor:
Scott G; Department of Exploratory Clinical Development, Novartis Pharmaceuticals, Horsham, UK. christiane.rordorf@pharma.novartis.com, Vinluan Reynolds C, Milosavljev S, Langholff W, Shenouda M, Rordorf C
Publikováno v:
Clinical pharmacokinetics [Clin Pharmacokinet] 2004; Vol. 43 (5), pp. 341-8.