Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christine C. Siska"'
Publikováno v:
Journal of Pharmaceutical Sciences
An early-phase development shipping study was designed to interrogate the stability of liquid formulations under normal shipping conditions. Parcel shipments were made between Seattle, WA, and Indianapolis, IN, during 2018-2019. Each parcel contained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::715a12c86a079003a35ef729c1cbc3a3
https://doi.org/10.1016/j.xphs.2019.10.064
https://doi.org/10.1016/j.xphs.2019.10.064
Autor:
Chelsey Bennett, Mcclure Megan J, Georgia D. Tomaras, Michael S. Seaman, Clark Rutilio H, Randal R. Ketchem, J. Alaina Floyd, Kelly E. Seaton, Christine C. Siska, Yan Brodsky, Jeremy M. Shaver, Bryan T. Mayer, Nicole L. Yates, Bruce A. Kerwin, Alison J. Gillespie
Publikováno v:
Journal of Pharmaceutical Sciences
The broadly neutralizing anti-HIV antibody, 10-1074, is a highly somatically hypermutated IgG1 being developed for prophylaxis in sub-Saharan Africa. A series of algorithms were applied to identify potentially destabilizing residues in the framework
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752f2582d80bda3c1169fc5c9a92aaad
http://europepmc.org/articles/PMC6941225
http://europepmc.org/articles/PMC6941225
Autor:
Amimeur Tileli, Clark Rutilio H, Josh Smith, Danielle Van Citters, Bruce A. Kerwin, Jeremy M. Shaver, Randal R. Ketchem, Christine C. Siska, Smidt Pauline S, Megan Sprague, Dean Pettit, J. Alex Taylor
We demonstrate the use of a Generative Adversarial Network (GAN), trained from a set of over 400,000 light and heavy chain human antibody sequences, to learn the rules of human antibody formation. The resulting model surpasses common in silico techni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13fde634263f9f22e3613107036384e
Autor:
Jon Woodard, Randal R. Ketchem, Vladimir I. Razinkov, Ramil F. Latypov, Joanna L. Scavezze, Douglas D. Banks, Christine C. Siska
Publikováno v:
Journal of Pharmaceutical Sciences. 101:2720-2732
In the present report, two formulation strategies, based on different aggregation models, were compared for their ability to quickly predict which excipients (cosolutes) would minimize the aggregation rate of an immunoglobulin G1 monoclonal antibody
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294d24b3ef41c9b388539cea11eb4901
https://doi.org/10.1002/jps.23219
https://doi.org/10.1002/jps.23219
Autor:
Andrei A. Raibekas, Edward J. Bures, Bruce A. Kerwin, Tadahiko Kohno, Ramil F. Latypov, Christine C. Siska
Publikováno v:
Biochemistry. 44:9871-9879
Highly concentrated human recombinant interleukin-1 receptor antagonist (IL-1ra) aggregates at elevated temperature without perturbation in its secondary structure. The protein aggregation can be suppressed depending on the buffer ionic strength and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd10db6552723de59f35e0c53f99cd92
https://doi.org/10.1021/bi050388g
https://doi.org/10.1021/bi050388g
Publikováno v:
Journal of Bone and Mineral Research. 17:1954-1960
There is a decrease in cancellous bone mass and strength during lactation but these are partially or completely reconstituted in the postlactational period. The purpose of this study was to determine changes in cancellous bone structure and formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc821f7e850b61d5f8f045ff3fd85d60
https://doi.org/10.1359/jbmr.2002.17.11.1954
https://doi.org/10.1359/jbmr.2002.17.11.1954
Publikováno v:
Molecular pharmaceutics. 11(10)
Prescreening methods are needed in the biotechnology industry for rapid selection of protein therapeutic candidates and formulations of low aggregation propensity. In recent reports solubility measurements have shown promise as one such method, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2988608b8212be3568c2bedf8c9219
https://pubmed.ncbi.nlm.nih.gov/25144791
https://pubmed.ncbi.nlm.nih.gov/25144791
Autor:
Jennifer R. Litowski, Xiaolin Cao, Christine C. Siska, R. Matthew Fesinmeyer, Stephen R. Brych, Gerd R. Kleemann, Christopher J. Pierini, Zai-Qing Wen
Publikováno v:
Journal of pharmaceutical sciences. 104(2)
We report, for the first time, the identification of fatty acid particles in formulations containing the surfactant polysorbate 20. These fatty acid particles were observed in multiple mAb formulations during their expected shelf life under recommend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c99b25426a211dbb66e15b5805a7a015
https://pubmed.ncbi.nlm.nih.gov/25175016
https://pubmed.ncbi.nlm.nih.gov/25175016
Autor:
Ramil F. Latypov, Christopher J. Pierini, Christine C. Siska, Jennifer R. Litowski, Hollis Lau, R. Matthew Fesinmeyer
Publikováno v:
Journal of pharmaceutical sciences. 104(2)
Polysorbate 20 (PS20) is a nonionic surfactant frequently used to stabilize protein biopharmaceuticals. During the development of mAb formulations containing PS20, small clouds of particles were observed in solutions stored in vials. The degree of pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00f1b48eb649e28c44791c5dc05cc0a
https://pubmed.ncbi.nlm.nih.gov/25196966
https://pubmed.ncbi.nlm.nih.gov/25196966
Autor:
Joanna L. Scavezze, Douglas D. Banks, David M. Hambly, Christine C. Siska, Himanshu S. Gadgil
Publikováno v:
Analytical chemistry. 81(17)
In biopharmaceutical process development, it is desirable to identify sites of covalent degradations to ensure product consistency. One characterization method used for therapeutic immunoglobulin gamma (IgG) 1 antibodies is limited LysC proteolysis f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dea1b63a1eedf992e222510d6ffba6e
https://pubmed.ncbi.nlm.nih.gov/19630420
https://pubmed.ncbi.nlm.nih.gov/19630420