Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Christine C. Krieger"'
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Proximity ligation assay (PLA) is a methodology that permits detection of protein-protein closeness, that is, proteins that are within 40 nanometers of each other, in cells or tissues at endogenous protein levels or after exogenous overexpression. It
Externí odkaz:
https://doaj.org/article/1cb9e80cace34ebf833aba6846c8ea5d
Autor:
Alisa Boutin, Christine C. Krieger, Bernice Marcus-Samuels, Joanna Klubo-Gwiezdzinska, Susanne Neumann, Marvin C. Gershengorn
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Thyrotropin hormone (TSH) was reported to exhibit biphasic regulation of cAMP production in human thyroid slices; specifically, upregulation at low TSH doses transitioning to inhibition at high doses. We observed this phenomenon in HEK293 cells overe
Externí odkaz:
https://doaj.org/article/49e79ccc53424a4d88739ab01a3fccf3
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 18, p 6561 (2020)
In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (T
Externí odkaz:
https://doaj.org/article/9491ae088505434897e9636050723a1f
Autor:
Marius N Stan, Christine C Krieger
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Context Teprotumumab therapy for thyroid eye disease (TED) patients represents a major step forward. It targets and inhibits the insulin-like growth factor-1 receptor (IGF-1R), and its effectiveness is based on its interconnectedness with the thyrotr
Autor:
Marvin C. Gershengorn, Xiangliang Sui, Susanne Neumann, George J. Kahaly, Christine C Krieger
Publikováno v:
J Clin Endocrinol Metab
Context We previously presented evidence that TSH receptor (TSHR)-stimulating autoantibodies (TSAbs) bind to and activate TSHRs but do not bind to IGF1 receptors (IGF1Rs). Nevertheless, we showed that IGF1Rs were involved in thyroid eye disease (TED)
Publikováno v:
Eur Thyroid J
Graves’ disease (GD) is an autoimmune disease caused in part by thyroid-stimulating antibodies (TSAbs) that activate the thyroid-stimulating hormone receptor (TSHR). In Graves’ hyperthyroidism (GH), TSAbs cause persistent stimulation of thyroid c
Autor:
Joanna Klubo-Gwiezdzinska, Christine C Krieger, Bernice Marcus-Samuels, Susanne Neumann, Sarah S. Malik, Marvin C. Gershengorn, Elena Eliseeva, Daesong Jang
Publikováno v:
Molecular Pharmacology. 97:2-8
The thyrotropin (TSH) receptor (TSHR) signals via G proteins of all four classes and β-arrestin 1. Stimulation of TSHR leads to increasing cAMP production that has been reported as a monotonic dose-response curve that plateaus at high TSH doses. In
Autor:
George J. Kahaly, Susanne Neumann, Asma Azam, Christine C Krieger, Marvin C. Gershengorn, Joanna Klubo-Gwiezdzinska
Publikováno v:
Thyroid
Background: The pathogenesis of Graves' hyperthyroidism (GH) and associated Graves' orbitopathy (GO) appears to involve stimulatory autoantibodies (thyrotropin receptor [TSHR]-stimulating antibodies [TSAbs]) that bind to and activate TSHRs on thyrocy
Autor:
Christine C Krieger
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6561, p 6561 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (T