Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Christine C. Hinkle"'
Autor:
Hanrui Zhang, Chenyi Xue, Ying Wang, Jianting Shi, Xuan Zhang, Wenjun Li, Sara Nunez, Andrea S. Foulkes, Jennie Lin, Christine C. Hinkle, Wenli Yang, Edward E. Morrisey, Daniel J. Rader, Mingyao Li, Muredach P. Reilly
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 11 (2017)
BackgroundSustained and dysfunctional macrophage activation promotes inflammatory cardiometabolic disorders, but the role of long intergenic noncoding RNA (lincRNA) in human macrophage activation and cardiometabolic disorders is poorly defined. Throu
Externí odkaz:
https://doaj.org/article/ffed54515cd242fb9154acb0d3b8bb33
Autor:
Muredach P. Reilly, Rachana Shah, Christine C. Hinkle, Jane F. Ferguson, Hanrui Zhang, Mark Gerelus, Jennifer Caughey, Emma Lynch, Gina Lynch, Sean O’Neill, Rexford S. Ahima, Andrew Tsai, Jianting Shi
Publikováno v:
Obesity. 25:1410-1420
Objective The purpose of the study was to explore the impact of dual targeting of C-C motif chemokine receptor-2 (CCR2) and fractalkine receptor (CX3CR1) on the metabolic and inflammatory consequences of obesity induced by a high-fat diet (HFD). Meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbfa3cbe56bdf4c31057a992cf024692
https://doi.org/10.1002/oby.21900
https://doi.org/10.1002/oby.21900
Autor:
Chenyi Xue, Benjamin A. Garcia, Wen Liu, Wenjun Li, Xuan Zhang, Melanie Hachet, Yumiao Han, John B. Hogenesch, Muredach P. Reilly, Patrick Seale, Jennie Lin, Sager J. Gosai, Jane F. Ferguson, Amber K. Weiner, Brian D. Gregory, Raymond E. Soccio, Mingyao Li, Hongfeng Jiang, Christine C. Hinkle
Long intergenic noncoding RNAs (lincRNAs) have emerged as important modulators of cellular functions. Most lincRNAs are not conserved among mammals, raising the fundamental question of whether nonconserved adipose-expressed lincRNAs are functional. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9eb738f9a7c3cafd946c68cea91b6f7
https://europepmc.org/articles/PMC6620026/
https://europepmc.org/articles/PMC6620026/
Autor:
Hanrui Zhang, Edward E. Morrisey, Sager J. Gosai, Kate Bermingham, Christine C. Hinkle, Muredach P. Reilly, Evanthia E. Pashos, Marina Cuchel, Wenjun Li, John S. Millar, Ruilan Yan, Stella T. Chou, Ying Liu, Jennifer Tabita-Martinez, Chenyi Xue, Amrith Rodrigues, Wenli Yang, Daniel J. Rader, Daniel VanDorn, Rhia Shah, Mingyao Li, Brian D. Gregory
Publikováno v:
Circulation Research. 117:17-28
Rationale: An efficient and reproducible source of genotype-specific human macrophages is essential for study of human macrophage biology and related diseases. Objective: To perform integrated functional and transcriptome analyses of human induced pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acc90169da44c924681263b248a1987
https://doi.org/10.1161/circresaha.117.305860
https://doi.org/10.1161/circresaha.117.305860
Autor:
Chenyi Xue, Daniel J. Rader, Hanrui Zhang, Christine C. Hinkle, Wenjun Li, Muredach P. Reilly, Edward E. Morrisey, Ying Wang, Mingyao Li, Jennie Lin, Andrea S. Foulkes, Wenli Yang, Xuan Zhang, Sara Nunez, Jianting Shi
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Sustained and dysfunctional macrophage activation promotes inflammatory cardiometabolic disorders, but the role of long intergenic noncoding RNA (linc RNA ) in human macrophage activation and cardiometabolic disorders is poorly defined. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae012828e0566af2383bb60c9820829
http://europepmc.org/articles/PMC5721798
http://europepmc.org/articles/PMC5721798
Autor:
Ying Wang, Chenyi Xue, Christine C. Hinkle, Xuan Zhang, Hanrui Zhang, Jane F. Ferguson, Muredach P. Reilly, Mingyao Li
Long intergenic noncoding RNAs (lincRNAs) have emerged as key regulators of cellular functions and physiology. Yet functional lincRNAs often have low, context-specific and tissue-specific expression. We hypothesized that many human monocyte and adipo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f41e7faf4064d07b2565b5da1fd818
https://europepmc.org/articles/PMC5495909/
https://europepmc.org/articles/PMC5495909/
Autor:
Stephen Stephan, Ruben H. Hovhannisyan, Muredach P. Reilly, Rexford S. Ahima, Arbansjit Sandhu, Julie Johnston, Sean O’Neill, William R. Lagor, Shu-Jen Chen, Christine C. Hinkle
Publikováno v:
Gene therapy
Adipose tissue has a critical role in energy and metabolic homeostasis, but it is challenging to adapt techniques to modulate adipose function in vivo. Here we develop an in vivo, systemic method of gene transfer specifically targeting adipose tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f10386c241acea66b48356fc6bd24e1
http://europepmc.org/articles/PMC4342115
http://europepmc.org/articles/PMC4342115
Autor:
Christine C. Hinkle, Christopher M. Overall, Wenjun Li, Muredach P. Reilly, Theo Klein, Kristy Ou, Jian Cui, Xuan Zhang
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 36
ADAMTS7 , a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family, has been recently identified as a novel genetic locus for coronary artery disease. Although a handful of ADAMTS7 substrates have been identified t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cca732bd14fd71badecc6929ef0d1aa4
https://doi.org/10.1161/atvb.36.suppl_1.267
https://doi.org/10.1161/atvb.36.suppl_1.267
Autor:
Lalarukh Haris, Nehal N. Mehta, Christine C. Hinkle, Muredach P. Reilly, Rhia Shah, Mary E. Putt, Rachana Shah
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 97:E2152-E2159
Context: Adipose inflammation is a crucial link between obesity and its metabolic complications. Human experimental endotoxemia is a controlled model for the study of inflammatory cardiometabolic responses in vivo. Objective: We hypothesized that adi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9169fd37418d620267540ed6e0b08a4
https://doi.org/10.1210/jc.2012-1988
https://doi.org/10.1210/jc.2012-1988
Autor:
Fiona C. McGillicuddy, Margarita de la Llera Moya, Leticia Pruscino, Jennifer Tabita-Martinez, Megan L. Wolfe, Michael Byrne, Christine C. Hinkle, Muredach P. Reilly, Nehal N. Mehta, Michelle R. Joshi, Karen O. Badellino, Bela F. Asztalos, Vihn Nguyen
Publikováno v:
Atherosclerosis. 222:390-394
Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans.We employed low-dose human endotoxemia to assess the effects of inflammation on HDL and RCT-related par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b510b3ef8d67f3f5762a9f7f4d4cf60
https://doi.org/10.1016/j.atherosclerosis.2012.02.032
https://doi.org/10.1016/j.atherosclerosis.2012.02.032