Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Christine C. Helms"'
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Erythrocytes regulate vascular function through the modulation of oxygen delivery and the scavenging and generation of nitric oxide (NO). First, hemoglobin inside the red blood cell binds oxygen in the lungs and delivers it to tissues throughout the
Externí odkaz:
https://doaj.org/article/2e8222995955461aa5fb4faea163d2e4
Autor:
Najnin Rimi, Christine C. Helms
BackgroundFluorescent beads are often used as a tool for visualizing fibrin fibers and can mimic the size of microparticles in the blood. Studies showed microparticles alter the appearance and behavior of whole blood clot systems.ObjectivesHere we in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3cf25feede63f11ec1bfbafa94e00fbe
https://doi.org/10.1101/2021.09.22.461388
https://doi.org/10.1101/2021.09.22.461388
Autor:
Mary T Kinney, Marlien Pieters, Stephen R. Baker, Roger Cubcciotti, Justin Sigley, Peter H. Brubaker, Martin Guthold, Christine C. Helms, Wei Li
Publikováno v:
BioMed Research International, Vol 2017 (2017)
BioMed Research International
BioMed Research International
The major structural component of a blood clot is a meshwork of fibrin fibers. It has long been thought that the internal structure of fibrin fibers is homogeneous; that is, the protein density and the bond density between protofibrils are uniform an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f4a84ee5e82888eba32544332b3779
https://doi.org/10.1155/2017/6385628
https://doi.org/10.1155/2017/6385628
Publikováno v:
Biological Chemistry. 398:319-329
Nitrite was once thought to be inert in human physiology. However, research over the past few decades has established a link between nitrite and the production of nitric oxide (NO) that is potentiated under hypoxic and acidic conditions. Under this n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7757213a9f2fff5efded05c5dd21ff
https://doi.org/10.1515/hsz-2016-0263
https://doi.org/10.1515/hsz-2016-0263
Autor:
John W. Weisel, Marlien Pieters, Martin Guthold, Chandrasekaran Nagaswami, Christine C. Helms, Wei Li, Justin Sigley
Publikováno v:
Biophysical Journal. 110:1400-1410
The major structural component of a blood clot is a mesh of fibrin fibers. Our goal was to determine whether fibrinogen glycation and fibrin fiber diameter have an effect on the mechanical properties of single fibrin fibers. We used a combined atomic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ac49bd9c0ef7a7203a29405e3356f00
https://doi.org/10.1016/j.bpj.2016.02.021
https://doi.org/10.1016/j.bpj.2016.02.021
Autor:
Christian Keggi, John Janes, Chen Liu, Christine C. Helms, Nadeem Wajih, David L. Caudell, Daniel B. Kim-Shapiro, Amber N. Lee, Mark T. Gladwin, Jun Wang, Madison Marvel, Andrea Belanger, Swati Basu, Debra I. Diz, Xiaohua Liu, Paul J. Laurienti
Publikováno v:
Journal of Biological Chemistry. 290:1281-1294
Nitrite signaling likely occurs through its reduction to nitric oxide (NO). Several reports support a role of erythrocytes and hemoglobin in nitrite reduction, but this remains controversial, and alternative reductive pathways have been proposed. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beadf5c0564b8bce6cd17fab48f38227
https://doi.org/10.1074/jbc.m114.609222
https://doi.org/10.1074/jbc.m114.609222
Publikováno v:
Frontiers in Physiology
Frontiers in Physiology, Vol 9 (2018)
Frontiers in Physiology, Vol 9 (2018)
Erythrocytes regulate vascular function through the modulation of oxygen delivery and the scavenging and generation of nitric oxide (NO). First, hemoglobin inside the red blood cell binds oxygen in the lungs and delivers it to tissues throughout the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b254607d3a6db3bda6f60fc088b6909
https://pubmed.ncbi.nlm.nih.gov/29520238
https://pubmed.ncbi.nlm.nih.gov/29520238
Autor:
Kenneth E. Remy, Junfeng Sun, Harvey G. Klein, Mark T. Gladwin, Tamir Kanias, Meghna Alimchandani, Daniel B. Kim-Shapiro, Irene Cortés-Puch, Dong Wang, Jing Feng, Martha Quezado, Christine C. Helms, Steven B. Solomon, Charles Natanson, Andreas Perlegas
Publikováno v:
Transfusion. 54:1712-1724
Background In experimental pneumonia we found that transfused older blood increased mortality and lung injury that was associated with increased in vivo hemolysis and elevated plasma cell-free hemoglobin (CFH), non–transferrin-bound iron (NTBI), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b165e505dff3919f8197fb664e83ac7
https://doi.org/10.1111/trf.12607
https://doi.org/10.1111/trf.12607
Publikováno v:
Free Radical Biology and Medicine. 61:464-472
The rate that hemoglobin reacts with nitric oxide (NO) is limited by how fast NO can diffuse into the heme pocket. The reaction is as fast as any ligand/protein reaction can be and the result, when hemoglobin is in its oxygenated form, is formation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea52083d228026142f947b03a628269f
https://doi.org/10.1016/j.freeradbiomed.2013.04.028
https://doi.org/10.1016/j.freeradbiomed.2013.04.028
In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines
Autor:
Barbora Piknova, Christine C. Helms, Steven B. Solomon, Mark T. Gladwin, Steven J. Kern, Charles Natanson, Dong Wang, Daniel B. Kim-Shapiro, Junfeng Sun, Alan N. Schechter, Irene Cortés-Puch, Tamir Kanias
Publikováno v:
Transfusion. 53:3149-3163
BACKGROUND Cell-free hemoglobin (Hb) in the vasculature leads to vasoconstriction and injury. Proposed mechanisms have been based on nitric oxide (NO) scavenging by oxyhemoglobin (oxyHb) or processes mediated by oxidative reactions of methemoglobin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2eae66edf08bcbef41d22e3e6ece0be
https://doi.org/10.1111/trf.12162
https://doi.org/10.1111/trf.12162