Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Christine C. Hedli"'
Publikováno v:
Toxicological Sciences. 49:40-47
A previous report from this laboratory focused on the metabolism of [ 14 C]benzene (BZ) in the isolated, perfused, mouse liver (C. C. Hedli, et al., 1997, Toxicol. Appl. Pharmacol. 146, 60-68). Whereas administration of BZ to mice results in bone mar
Publikováno v:
Journal of Applied Toxicology. 18:173-178
Exposure of experimental animals to toxaphene induces hepatic cytochrome P-450 (CYP). Although chronic administration of toxaphene to mice was found to cause an increased incidence of liver tumors, a mechanism for its carcinogenicity has yet to be el
Publikováno v:
Toxicology and Applied Pharmacology. 146:60-68
The hematotoxicity of benzene (BZ) requires its hepatic metabolism, the release of metabolites into the circulation, and the access of metabolites to the bone marrow. Although a range of potentially toxic metabolites produced by the liver was identif
Publikováno v:
International Journal of Toxicology. 16:419-432
The evaluation of health risk from chemical exposure is evolving in concept and practice. The ability to sensitively detect levels of chemicals in the environment has served as the traditional foundation for determining exposure levels and consequent
Autor:
Christine C. Hedli, Robert Snyder
Publikováno v:
Environmental Health Perspectives
Benzene toxicity involves both bone marrow depression and leukemogenesis caused by damage to multiple classes of hematopoietic cells and a variety of hematopoietic cell functions. Study of the relationship between the metabolism and toxicity of benze
Publikováno v:
Archives of Toxicology. 70:135-144
Reactive metabolites of benzene (BZ) play important roles in BZ-induced hematotoxicity. Although reactive metabolites of BZ covalently bind to DNA, the significance of DNA adduct formation in the mechanism of BZ toxicity is not clear. These studies i
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781468458794
Benzenel (BZ) is a widely used industrial solvent, exposure to which has been linked to the development of aplastic anemia and leukemia. BZ is an animal carcinogen (Cronkite et al., 1984), but the ultimate carcinogenic metabolite still has not been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59fe4e82398c0eb24ba42a6699262e48
https://doi.org/10.1007/978-1-4684-5877-0_98
https://doi.org/10.1007/978-1-4684-5877-0_98