Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Christine C., Stichel"'
Autor:
Teresa Sczepan, Saskia Schmidt, Christine C. Stichel, Sonja Mendritzki, Matthias Lübbert, Hermann Lübbert, Bettina Linnartz
Publikováno v:
Human Molecular Genetics. 20:1197-1211
We recently described mitochondrial pathology in neurons of transgenic mice with genes associated with Parkinson's disease (PD). Now we describe severe mitochondrial damage in glial cells of the mesencephalon in mice carrying a targeted deletion of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b35646dd1eca1e1582fdd02751eb4fb
https://doi.org/10.1093/hmg/ddq564
https://doi.org/10.1093/hmg/ddq564
Autor:
Christine C. Stichel, Alexander Schönefuß, Klaus Hoffmann, Roxane Schulten, Christian Tigges, Hermann Lübbert, Wiebke Wendt, Markus Stuecker, Benjamin Schattling
Publikováno v:
Experimental Dermatology. 19:e80-e88
Please cite this paper as: Upregulation of cathepsin S in psoriatic keratinocytes. Experimental Dermatology 2010; 19: e80–e88. Abstract: Cathepsin S (CATS) is a cysteine protease, well known for its role in MHC class II-mediated antigen presentatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f42b384a4abee9b0aa804b14d3249032
https://doi.org/10.1111/j.1600-0625.2009.00990.x
https://doi.org/10.1111/j.1600-0625.2009.00990.x
Publikováno v:
Journal of Neurochemistry. 110:1931-1941
Activated microglia release inflammatory mediators that display either beneficial or harmful effects on neuronal survival and signaling. In the present study we demonstrate that exposure to lipopolysaccharide leads to an increase in the lysosomal cys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ebfb75acb4ba251e0a61e03a5f0d5b
https://doi.org/10.1111/j.1471-4159.2009.06283.x
https://doi.org/10.1111/j.1471-4159.2009.06283.x
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 379:627-636
Cannabinoid receptor (CB) agonists are known to attenuate allodynia in a range of pain models, but their long-term effects and their mechanisms of action are controversial. The present study compares the antiallodynic effects of long-term treatment w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed42dffa6e7d009d790766ef3142ae9
https://doi.org/10.1007/s00210-008-0386-4
https://doi.org/10.1007/s00210-008-0386-4
Autor:
Xin-Ran Zhu, Hermann Lübbert, Onur Güntürkün, Christine C. Stichel, Christina Herold, Lyutha Maskri, Verian Bader
Publikováno v:
European Journal of Neuroscience. 26:1902-1911
Mutations in the parkin gene are the major cause of early-onset familial Parkinson’s disease (PD). We previously reported the generation and analysis of a knockout mouse carrying a deletion of exon 3 in the parkin gene. F1 hybrid pa+ ⁄‐ mice we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47068f1f2a8a1c37652bacdc5547ce63
https://doi.org/10.1111/j.1460-9568.2007.05812.x
https://doi.org/10.1111/j.1460-9568.2007.05812.x
Autor:
Hermann Lübbert, Bettina Linnartz, Xin-Ran Zhu, Christine C. Stichel, Saskia Schmidt, Verian Bader
Publikováno v:
Human Molecular Genetics. 16:2377-2393
Mutations in the gene encoding alpha-synuclein (asyn) causes autosomal-dominant, in the parkin gene autosomal-recessive forms of Parkinson's disease (PD). The pathophysiology of PD is poorly understood, even though published evidence suggests a role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25eb3045aaedc01e7cb1a1c2e2173730
https://doi.org/10.1093/hmg/ddm083
https://doi.org/10.1093/hmg/ddm083
Publikováno v:
Experimental Neurology. 204:525-540
Increasing evidence of a fundamental influence of cathepsins on inflammation has drawn interest in a thorough understanding of their role in physiological and pathological processes. Even though the number of identified cathepsins has more than doubl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55059fbfc34706e569c45cf7f8c002e1
https://doi.org/10.1016/j.expneurol.2007.01.007
https://doi.org/10.1016/j.expneurol.2007.01.007
Autor:
Bodo Schoenebeck, Xin-Ran Zhu, Verian Bader, Beate Schmitz, Christine C. Stichel, Hermann Lübbert
Publikováno v:
Molecular and Cellular Neuroscience. 30:249-264
Serum and glucocorticoid-regulated kinase 1 (sgk1) belongs to a family of serine/threonine kinases that is under acute transcriptional control by serum and glucocorticoids. An expanding set of receptors and cellular stress pathways has been shown to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38502cef7a5fd0f46a4583a2981fd12a
https://doi.org/10.1016/j.mcn.2005.07.017
https://doi.org/10.1016/j.mcn.2005.07.017
Publikováno v:
Brain Research. 1041:102-111
Recessively inherited mutations in DJ-1 have recently been linked to familial forms of parkinsonism. However, the regional and cellular expression of DJ-1 is largely unknown. In the present study, we mapped the distribution of DJ-1 transcript and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe4d125a97b7cbbbed71e9aaa7e7e36
https://doi.org/10.1016/j.brainres.2005.02.006
https://doi.org/10.1016/j.brainres.2005.02.006
Autor:
Sabrina Fritzen, Xin-Ran Zhu, M. Andriske, Lyutha Maskri, Peter Engels, Christoph Ullmer, Kati Kühn, Hermann Lübbert, Christine C. Stichel
Publikováno v:
Neurodegenerative Diseases. 1:255-265
Two missense mutations (A53T and A30P) in the gene encoding the presynaptic protein α-synuclein (asyn) are associated with rare, dominantly inherited forms of Parkinson’s disease (PD) and its accumulation in Lewy bodies and Lewy neurites. As an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b21f73c07589204b8ce5bcd082d28c
https://doi.org/10.1159/000085064
https://doi.org/10.1159/000085064