Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Christine C Krieger"'
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Proximity ligation assay (PLA) is a methodology that permits detection of protein-protein closeness, that is, proteins that are within 40 nanometers of each other, in cells or tissues at endogenous protein levels or after exogenous overexpression. It
Externí odkaz:
https://doaj.org/article/1cb9e80cace34ebf833aba6846c8ea5d
Autor:
Alisa Boutin, Christine C. Krieger, Bernice Marcus-Samuels, Joanna Klubo-Gwiezdzinska, Susanne Neumann, Marvin C. Gershengorn
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Thyrotropin hormone (TSH) was reported to exhibit biphasic regulation of cAMP production in human thyroid slices; specifically, upregulation at low TSH doses transitioning to inhibition at high doses. We observed this phenomenon in HEK293 cells overe
Externí odkaz:
https://doaj.org/article/49e79ccc53424a4d88739ab01a3fccf3
Autor:
Marius N Stan, Christine C Krieger
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Context Teprotumumab therapy for thyroid eye disease (TED) patients represents a major step forward. It targets and inhibits the insulin-like growth factor-1 receptor (IGF-1R), and its effectiveness is based on its interconnectedness with the thyrotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f7aeba74204b9e00fd43310e8f6717
https://doi.org/10.1210/clinem/dgad213
https://doi.org/10.1210/clinem/dgad213
Autor:
Marvin C. Gershengorn, Xiangliang Sui, Susanne Neumann, George J. Kahaly, Christine C Krieger
Publikováno v:
J Clin Endocrinol Metab
Context We previously presented evidence that TSH receptor (TSHR)-stimulating autoantibodies (TSAbs) bind to and activate TSHRs but do not bind to IGF1 receptors (IGF1Rs). Nevertheless, we showed that IGF1Rs were involved in thyroid eye disease (TED)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711d00c2b147adb63c86aad08b233af2
https://doi.org/10.1210/clinem/dgab824
https://doi.org/10.1210/clinem/dgab824
Autor:
George J. Kahaly, Susanne Neumann, Asma Azam, Christine C Krieger, Marvin C. Gershengorn, Joanna Klubo-Gwiezdzinska
Publikováno v:
Thyroid
Background: The pathogenesis of Graves' hyperthyroidism (GH) and associated Graves' orbitopathy (GO) appears to involve stimulatory autoantibodies (thyrotropin receptor [TSHR]-stimulating antibodies [TSAbs]) that bind to and activate TSHRs on thyrocy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea51e236b296a524e84f69141a90646
https://doi.org/10.1089/thy.2021.0326
https://doi.org/10.1089/thy.2021.0326
Publikováno v:
Eur Thyroid J
Graves’ disease (GD) is an autoimmune disease caused in part by thyroid-stimulating antibodies (TSAbs) that activate the thyroid-stimulating hormone receptor (TSHR). In Graves’ hyperthyroidism (GH), TSAbs cause persistent stimulation of thyroid c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6201baa2a42c2e5a8d4185495ccf6e0
https://doi.org/10.1159/000511538
https://doi.org/10.1159/000511538
Autor:
Joanna Klubo-Gwiezdzinska, Christine C Krieger, Bernice Marcus-Samuels, Susanne Neumann, Sarah S. Malik, Marvin C. Gershengorn, Elena Eliseeva, Daesong Jang
Publikováno v:
Molecular Pharmacology. 97:2-8
The thyrotropin (TSH) receptor (TSHR) signals via G proteins of all four classes and β-arrestin 1. Stimulation of TSHR leads to increasing cAMP production that has been reported as a monotonic dose-response curve that plateaus at high TSH doses. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed06ea0ce8f38e2db5972cddbe99a1ec
https://doi.org/10.1124/mol.119.117382
https://doi.org/10.1124/mol.119.117382
Autor:
Christine C Krieger
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f4f67dce147f51cd50ed2851542bac
https://doi.org/10.1210/clinem/dgab500
https://doi.org/10.1210/clinem/dgab500
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6561, p 6561 (2020)
International Journal of Molecular Sciences
International Journal of Molecular Sciences
In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a61e5c414f4fab9eb70c895a557398
https://www.mdpi.com/1422-0067/21/18/6561
https://www.mdpi.com/1422-0067/21/18/6561
Autor:
Christine C Krieger, Joanna Klubo-Gwiezdzinska, Susanne Neumann, Marvin C. Gershengorn, Bernice Marcus-Samuels, Alisa Boutin
Publikováno v:
Frontiers in Endocrinology
Frontiers in Endocrinology, Vol 11 (2020)
Frontiers in Endocrinology, Vol 11 (2020)
Thyrotropin hormone (TSH) was reported to exhibit biphasic regulation of cAMP production in human thyroid slices; specifically, upregulation at low TSH doses transitioning to inhibition at high doses. We observed this phenomenon in HEK293 cells overe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8035f19157642d26fc7e5ea22f2ba373
https://pubmed.ncbi.nlm.nih.gov/32425890
https://pubmed.ncbi.nlm.nih.gov/32425890