Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christine C, Hudson"'
Publikováno v:
Cancer Research. 81:1339-1339
Background: Somatic mutations in isocitrate dehydrogenase 1 (IDH1) arise in roughly 6-10% of patients with acute myeloid leukemia (AML). These mutations lead to the production of the oncometabolite 2-hydroxyglutarate at concentrations shown to interf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ceafac754b667b020649bd69913491a
https://doi.org/10.1158/1538-7445.am2021-1339
https://doi.org/10.1158/1538-7445.am2021-1339
Autor:
Richard Debiasio, Conrad L. Cowan, Richik N. Ghosh, Everett R. Ramer, Christine C. Hudson, Robert H. Oakley
Publikováno v:
SLAS Discovery. 10:476-484
The authors demonstrate the use of a simple, universal G-protein-coupled receptor (GPCR) assay to screen for agonists for a specific GPCR. Cells stably expressing a green fluorescent protein (GFP)-labeled beta-arrestin fusion protein and the vasopres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44827e359807d09c38f4e2c9b183be14
https://doi.org/10.1177/1087057105274896
https://doi.org/10.1177/1087057105274896
Autor:
Christine C. Hudson, Fiona Kaper, Robert T. Abraham, Diane M. Otterness, Mei Liu, Gary G. Chiang, Amato J. Giaccia, Dawn C. Loomis
Publikováno v:
Molecular and Cellular Biology. 22:7004-7014
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor containing an inducibly expressed HIF-1alpha subunit and a constititutively expressed HIF-1beta subunit. Under hypoxic conditions, the HIF-1alpha subunit accumulates due to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2300e242ea5bdd26c7704ad7c7398ad
https://doi.org/10.1128/mcb.22.20.7004-7014.2002
https://doi.org/10.1128/mcb.22.20.7004-7014.2002
Autor:
Christine C. Hudson, Robert H. Oakley, Judith Hernandez-Aranda, Frank M. Dautzenberg, Richard L. Hauger, Eric Gutknecht, Sandra Braun, J. Alberto Olivares-Reyes
Publikováno v:
Regulatory peptides. 186
The primary goal was to determine agonist-specific regulation of CRF 2(a) receptor function. Exposure of human retinoblastoma Y79 cells to selective (UCN2, UCN3 or stresscopins) and non-selective (UCN1 or sauvagine) agonists prominently desensitized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3c049437196d05ef50c8d519f379933
https://pubmed.ncbi.nlm.nih.gov/23820308
https://pubmed.ncbi.nlm.nih.gov/23820308
Autor:
Richard L. Hauger, J. Alberto Olivares-Reyes, Fabiola Flores-Vega, Christine C. Hudson, Robert H. Oakley, Frank M. Dautzenberg
Publikováno v:
American journal of physiology. Regulatory, integrative and comparative physiology. 293(1)
The primary goal was to test the hypothesis that agonist-induced corticotropin-releasing factor type 1 (CRF1) receptor phosphorylation is required for β-arrestins to translocate from cytosol to the cell membrane. We also sought to determine the rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7845d9d2bb675688f5da0fbc5a88591
https://pubmed.ncbi.nlm.nih.gov/17363685
https://pubmed.ncbi.nlm.nih.gov/17363685
Publikováno v:
Methods in enzymology. 414
Finding natural and/or synthetic ligands that activate orphan G protein-coupled receptors (oGPCRs) is a major focus in current drug discovery efforts. Transfluor is a cell-based GPCR screening platform that utilizes an arrestin-green fluorescent prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c2e9b9cc15ccbad09525c6c9937ed6e
https://pubmed.ncbi.nlm.nih.gov/17110186
https://pubmed.ncbi.nlm.nih.gov/17110186
Publikováno v:
Methods in enzymology. 414
G protein-coupled receptors (GPCRs) have proven to be one of the most successful target classes for drug discovery. Accordingly, many assays are available to screen GPCRs, including radioactive-binding assays, second messenger signaling assays, and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::016b3ea6990bc3059354e8bcf7d69a17
https://pubmed.ncbi.nlm.nih.gov/17110187
https://pubmed.ncbi.nlm.nih.gov/17110187
Finding natural and/or synthetic ligands that activate orphan G protein-coupled receptors (oGPCRs) is a major focus in current drug discovery efforts. Transfluor is a cell-based GPCR screening platform that utilizes an arrestin-green fluorescent prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82a2f5839875ed46dfa6b516ade3eaf2
https://doi.org/10.1016/s0076-6879(06)14004-5
https://doi.org/10.1016/s0076-6879(06)14004-5
G protein‐coupled receptors (GPCRs) have proven to be one of the most successful target classes for drug discovery. Accordingly, many assays are available to screen GPCRs, including radioactive‐binding assays, second messenger signaling assays, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9097637e2c7c87e267f4364ac7b7179
https://doi.org/10.1016/s0076-6879(06)14005-7
https://doi.org/10.1016/s0076-6879(06)14005-7
Autor:
Hajime Hosoi, Aleksandar Sekulic, Christine C. Hudson, Josie M. Williams, Gregory J. Brunn, Robert T. Abraham, Peter J. Houghton, John C. Lawrence
Publikováno v:
Science. 277:99-101
The immunosuppressant rapamycin interferes with G 1 -phase progression in lymphoid and other cell types by inhibiting the function of the mammalian target of rapamycin (mTOR). mTOR was determined to be a terminal kinase in a signaling pathway that co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d28a43534ce237de7537507a79b0cc94
https://doi.org/10.1126/science.277.5322.99
https://doi.org/10.1126/science.277.5322.99