Differential Structural Properties of GLP-1 and Exendin-4 Determine Their Relative Affinity for the GLP-1 Receptor N-Terminal Extracellular Domain

Autor: Susann Schimmer, Henning Thøgersen, Steffen Runge, Sanne Möller Knudsen, Jesper Lau, Rainer Rudolph, Kjeld Madsen, Jan Oschmann, Claus Bekker Jeppesen, Christine Bruun Schiødt

Publikováno v: Biochemistry. 46:5830-5840

Glucagon-like peptide-1 (GLP-1) and exendin-4 (Ex4) are homologous peptides with established potential for treatment of type 2 diabetes. They bind and activate the pancreatic GLP-1 receptor (GLP-1R) with similar affinity and potency and thereby promo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2178a15d6eab146d6bd8b086f4dfbba9
https://doi.org/10.1021/bi062309m

Kinetic evidence for surface residues influencing the active site of Coprinus cinereus peroxidase: analysis of the pH dependence of G154E, P90H and P90H–G154E substrate entrance mutants

Autor: Christine Bruun Schiødt, Karen G. Welinder, Paola Di Cerbo

Publikováno v: Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1544:18-27

Three mutants of Coprinus cinereus peroxidase (CIP) were made to mimic the substrate entrance histidine 82-glutamic acid 146 pair of the substrate channel in lignin peroxidase (LIP). Compound I formation of LIP has a low pH optimum around pH 3, while

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d31291b2a3469c5210c3e99469ffea
https://doi.org/10.1016/s0167-4838(00)00201-6

The Quantum Mixed-Spin Heme State of Barley Peroxidase:A Paradigm for Class III Peroxidases

Autor: Mario P. Marzocchi, Jian-Guo Ma, Barry D. Howes, Giulietta Smulevich, Jun Zhang, Karen G. Welinder, Christine Bruun Schiødt, John A. Shelnutt

Publikováno v: Howes, B D, Schiødt, C B, Welinder, K G, Marzocchi, M P, Ma, J-G, Zhang, J, Shelnutt, J A & Smulevich, G 1999, ' The Quantum Mixed-Spin Heme State of Barley Peroxidase : a Paradigm for Class III Peroxidases ', Biophysical Journal, vol. 77, pp. 478-492 .
Scopus-Elsevier

Electronic absorption and resonance Raman (RR) spectra of the ferric form of barley grain peroxidase (BP 1) at various pH values, at both room temperature and 20K, are reported, together with electron paramagnetic resonance spectra at 10K. The ferrou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76e5176745adbe1cb7349662cf6ea2c1
https://doi.org/10.1016/s0006-3495(99)76905-5

Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity

Autor: Lennart Franzén, Anne-Marie Heegaard, Christine Bruun Schiødt, Juha Risteli, Thomas Levin Andersen, Troels T. Andreassen, Jean-Marie Delaissé, Lars N. Jorgensen, Vikas Surve, Line Andersen, Magnus S. Ågren

Publikováno v: Agren, M S, Levin Andersen, T, Andersen, L, Schiødt, C B, Surve, V, Andreassen, T T, Risteli, J, Franzén, L E, Delaissé, J-M, Heegaard, A-M & Jorgensen, L N 2011, ' Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrity ', International Journal of Colorectal Disease, vol. 26, no. 3, pp. 329-337 . https://doi.org/10.1007/s00384-010-1106-3

Increased matrix metalloproteinase (MMP) activity has been implicated in the pathogenesis of colorectal anastomotic leakage. Tumor necrosis factor-α (TNF-α) induces MMPs and may influence anastomosis repair.We assessed the efficacies of the nonsele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cac96068d0c07fa16bdec8cd9225eba
https://portal.findresearcher.sdu.dk/da/publications/1831de6a-d78f-4ffa-9347-a540636893bc

The existence of multiple conformers of interleukin-21 directs engineering of a superpotent analogue

Autor: Lishan Kang, Siv Annegrethe Hjorth, Peter Becker, Christine Bruun Schiødt, Diana Højmark Omkvist, Dennis Madsen, Anne Worsaae, Kent Bondensgaard, Jens Breinholt

Publikováno v: The Journal of biological chemistry. 282(32)

The high resolution three-dimensional structure of human interleukin (hIL)-21 has been resolved by heteronuclear NMR spectroscopy. Overall, the hIL-21 structure is dominated by a well defined central four-helical bundle, arranged in an up-up-down-dow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9839b44a90e8ad546089db1a2c7d2cb6
https://pubmed.ncbi.nlm.nih.gov/17565991