Effect of large targeted deletions on the mitotic stability of an extra chromosome mediating drug resistance in Leishmania

Autor: Patrick Bastien, Christine Blaineau, Michel Pagès, Buddy Ullman, Pascal Dubessay, Marie Françoise Lignon, Christophe Ravel

Publikováno v: Nucleic Acids Research. 29:3231-3240

A mitotically stable linear extra chromosome obtained in a Leishmania donovani strain rendered mycophenolic acid-resistant has been physically mapped. This 290-kb chromosome has an inverted duplicated structure around a central inversion region, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c8f0f86b0b7b8eb15956c355c7a50e
https://doi.org/10.1093/nar/29.15.3231

Conserved linkage groups associated with large-scale chromosomal rearrangements between Old World and New World Leishmania genomes

Autor: Patrick Wincker, Constança Britto, Patrick Bastien, Christine Blaineau, J. P. Dedet, Christophe Ravel, Michel Pagès

Publikováno v: Gene. 222:107-117

The genus Leishmania can be taxonomically separated into three main groups: the Old World subgenus L. (Leishmania), the New World subgenus L. (Leishmania) and the New World subgenus L. (Viannia). The haploid genome of Old World Leishmania species has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a1e8bad7b5b7df401143363dd60c25
https://doi.org/10.1016/s0378-1119(98)00472-7

Structural organisation of microsatellite families in the Leishmania genome and polymorphisms at two (CA)n loci

Autor: Christophe Ravel, Patrick Bastien, Christine Blaineau, Valérie Rossi, Michel Pagès, Patrick Wincker

Publikováno v: Molecular and Biochemical Parasitology. 65:271-282

In the present study, we have analysed the frequency and distribution of several microsatellite DNAs [(CA)n, (GGT)n and (GCA)n] in the genome of Leishmania. Hybridisation analysis on the molecular karyotypes of different Leishmania strains showed the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af204611552743d8f90351145f756df2
https://doi.org/10.1016/0166-6851(94)90078-7

Microtubule-severing proteins are involved in flagellar length control and mitosis in Trypanosomatids

Autor: Christine Blaineau, Nathalie Bourgeois, Michel Pagès, Magali Casanova, Lucien Crobu, Patrick Bastien

Publikováno v: Molecular Microbiology
Molecular Microbiology, Wiley, 2009, 71 (6), pp.1353-1370. ⟨10.1111/j.1365-2958.2009.06594.x⟩
Molecular Microbiology, 2009, 71 (6), pp.1353-1370. ⟨10.1111/j.1365-2958.2009.06594.x⟩

Microtubules are key players in the biology of Trypanosomatid parasites, not only as classical components of the mitotic spindle, microtubule-organizing centres and flagellum but also as the essential constituent of the cytoskeleton. Their length dyn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6058d43c9f81af38cba80bdb21d5d9f3
https://pubmed.ncbi.nlm.nih.gov/19183280

Inhibition of active nuclear transport is an intrinsic trigger of programmed cell death in trypanosomatids

Autor: Christine Blaineau, Magali Casanova, Patrick Bastien, Michel Pagès, Lucien Crobu, Pierre Portales

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, 2008, 15 (12), pp.1910-1920. ⟨10.1038/cdd.2008.132⟩
Cell Death and Differentiation, Nature Publishing Group, 2008, 15 (12), pp.1910-1920. ⟨10.1038/cdd.2008.132⟩

The link between nucleocytoplasmic transport and apoptosis remains controversial. Nucleocytoplasmic exchange of molecules seems indeed essential for the initiation and execution of the apoptotic programme; but inhibition of nuclear transport factors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de75c91adfa91e2476cb41ee2c716c7d
https://hal-amu.archives-ouvertes.fr/hal-02049718