Family-Based Association Studies of Lipid Gene Polymorphisms in Coronary Artery Disease

Autor: Damian Fogarty, Christine Belton, Adrian R. Allen, Alun Evans, Mark S. Spence, Paul G. Horan, Paul G. McGlinchey, Pascal P. McKeown, Christopher Patterson

Publikováno v: The American Journal of Cardiology. 96:52-55

Dysfunction of lipid-metabolizing proteins is implicated in the pathogenesis of coronary artery disease. Single nucleotide polymorphisms in genes that encode sterol regulatory binding protein-1a, adenosine triphosphate binding cassette-A1, hepatic li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a54184c1a7d016a19d9c9c6fc9d20e
https://doi.org/10.1016/j.amjcard.2005.02.043

Lack of association between the -2518G/A polymorphism of the MCP-1 gene and ischaemic heart disease: a family-based investigation

Autor: Christine Belton, Pascal P. McKeown, Gillian Murphy, Michelle Spence, Paul G. McGlinchey, Adrian R. Allen, Christopher Patterson

Publikováno v: Tissue Antigens. 64:199-203

Using two recently described family-based tests of association, the possible role of the functional –2518G/A polymorphism in the promoter region of the monocyte chemoattractant protein-1 (MCP-1) gene in the susceptibility to ischaemic heart disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7067ad72d4abf3d06e3dbb2d332e346d
https://doi.org/10.1111/j.0001-2815.2004.00281.x

Family-based investigation of the C677T polymorphism of the methylenetetrahydrofolate reductase gene in ischaemic heart disease

Autor: Mark S. Spence, Dorothy McMaster, Christopher Patterson, Damian Fogarty, Christine Belton, Alun Evans, Gillian Murphy, Paul G. McGlinchey, Pascal P. McKeown

Publikováno v: Atherosclerosis. 165:293-299

Background: Elevated homocysteine is associated with ischaemic heart disease (IHD). The C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene results in reduced MTHFR enzyme activity and reduced methylation of homocysteine to met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09305ca7a23adda21e59963494420a5
https://doi.org/10.1016/s0021-9150(02)00239-3

Lack of MEF2A Δ7aa mutation in Irish families with early onset ischaemic heart disease, a family based study

Autor: Christine Belton, Christopher Patterson, Anne E. Hughes, Paul G. Horan, Pascal P. McKeown, Adrian R. Allen, Paul G. McGlinchey, Tracy Jardine, Mark S. Spence

Publikováno v: BMC Medical Genetics
Horan, P G, Allen, A R, Hughes, A, Patterson, C, Spence, M, McGlinchey, P G, Belton, C, Jardine, T C L & McKeown, P 2006, ' Lack of MEF2A Δ7aa mutation in Irish families with early onset ischaemic heart disease, a family based study ' BMC Medical Genetics, vol 7, 65, pp. 65 . DOI: 10.1186/1471-2350-7-65
BMC Medical Genetics, Vol 7, Iss 1, p 65 (2006)

Background Ischaemic heart disease (IHD) is a complex disease due to the combination of environmental and genetic factors. Mutations in the MEF2A gene have recently been reported in patients with IHD. In particular, a 21 base pair deletion (Δ7aa) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8164b0a4a1e7fe3aa422113013e920a0
http://europepmc.org/articles/PMC1552052