Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Christine Beeton"'
Autor:
Teresina Laragione, Carolyn Harris, Nasim Azizgolshani, Christine Beeton, Gerold Bongers, Percio S. Gulko
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104603- (2023)
Summary: Background: Rheumatoid arthritis (RA) is a common autoimmune disease with emerging environmental and microbiome risk factors. The western diet is typically deficient in magnesium (Mg), and there is some evidence suggesting that Mg may have a
Externí odkaz:
https://doaj.org/article/2bc7b2fb9af14aa9bb33509b454232bc
Autor:
Konstantin Tsoyi, Anthony J. Esposito, Bo Sun, Ryan G. Bowen, Kevin Xiong, Fernando Poli, Rafael Cardenas, Sarah G. Chu, Xiaoliang Liang, Stefan W. Ryter, Christine Beeton, Tracy J. Doyle, Matthew J. Robertson, Lindsay J. Celada, Freddy Romero, Souheil Y. El-Chemaly, Mark A. Perrella, I.-Cheng Ho, Ivan O. Rosas
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Rheumatoid arthritis (RA)-associated interstitial lung disease (RA-ILD) is the most common pulmonary complication of RA, increasing morbidity and mortality. Anti-citrullinated protein antibodies have been associated with the development and
Externí odkaz:
https://doaj.org/article/ec81a56a0af949f686db3bdeb3e61b1e
Autor:
Yuqing Wang, Ayrea Hurley, Marco De Giorgi, Mark R. Tanner, Rong-Chi Hu, Michael W. Pennington, William R. Lagor, Christine Beeton
Publikováno v:
PLoS ONE, Vol 18, Iss 4 (2023)
Targeting the Kv1.3 potassium channel has proven effective in reducing obesity and the severity of animal models of autoimmune disease. Stichodactyla toxin (ShK), isolated from the sea anemone Stichodactyla helianthus, is a potent blocker of Kv1.3. S
Externí odkaz:
https://doaj.org/article/ca2fd58e706445a2b6b685c437aebfe2
Autor:
Ioannis Markakis, Ioannis Charitakis, Christine Beeton, Melpomeni Galani, Elpida Repousi, Stella Aggeloglou, Petros P. Sfikakis, Michael W. Pennington, K. George Chandy, Cornelia Poulopoulou
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that
Externí odkaz:
https://doaj.org/article/0f9684dd16cb45ed9e75cfffbfd1bd3a
Autor:
Mark R. Tanner, Michael W. Pennington, Satendra S. Chauhan, Teresina Laragione, Pércio S. Gulko, Christine Beeton
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-21 (2019)
Abstract Background Fibroblast-like synoviocytes (FLS) and CCR7− effector memory T (TEM) cells are two of the major cell types implicated in the progression of rheumatoid arthritis (RA). In particular, FLS become highly invasive, whereas TEM cells
Externí odkaz:
https://doaj.org/article/96a71378e38d4196b2cdb3f6084d13a6
Autor:
Ralf Bergmann, Manja Kubeil, Kristof Zarschler, Sandeep Chhabra, Rajeev B. Tajhya, Christine Beeton, Michael W. Pennington, Michael Bachmann, Raymond S. Norton, Holger Stephan
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract The peptide HsTX1[R14A] is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, which is a highly promising target for the treatment of autoimmune diseases and other conditions. In order to assess the biodistribution
Externí odkaz:
https://doaj.org/article/df49b90ff84b43d9acf32897f9f258e4
Autor:
Mark R. Tanner, Redwan Huq, William K. A. Sikkema, Lizanne G. Nilewski, Nejla Yosef, Cody Schmitt, Carlos P. Flores-Suarez, Arielle Raugh, Teresina Laragione, Pércio S. Gulko, James M. Tour, Christine Beeton
Publikováno v:
Antioxidants, Vol 9, Iss 10, p 1005 (2020)
Reactive oxygen species have been involved in the pathogenesis of rheumatoid arthritis (RA). Our goal was to determine the effects of selectively scavenging superoxide (O2•−) and hydroxyl radicals with antioxidant nanoparticles, called poly(ethyl
Externí odkaz:
https://doaj.org/article/0b6c9d5781ea4e2ba724d980f85bbfc9
Autor:
Michael W. Pennington, Shih Chieh Chang, Satendra Chauhan, Redwan Huq, Rajeev B. Tajhya, Sandeep Chhabra, Raymond S. Norton, Christine Beeton
Publikováno v:
Marine Drugs, Vol 13, Iss 1, Pp 529-542 (2015)
ShK, from the sea anemone Stichodactyla helianthus, is a 35-residue disulfide-rich peptide that blocks the voltage-gated potassium channel Kv1.3 at ca. 10 pM and the related channel Kv1.1 at ca. 16 pM. We developed an analog of this peptide, ShK-186,
Externí odkaz:
https://doaj.org/article/c1c30af770e04c0a8a922513e4d0220d
Autor:
M Harunur Rashid, Germano Heinzelmann, Redwan Huq, Rajeev B Tajhya, Shih Chieh Chang, Sandeep Chhabra, Michael W Pennington, Christine Beeton, Raymond S Norton, Serdar Kuyucak
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78712 (2013)
The voltage-gated potassium channel Kv1.3 is a well-established target for treatment of autoimmune diseases. ShK peptide from a sea anemone is one of the most potent blockers of Kv1.3 but its application as a therapeutic agent for autoimmune diseases
Externí odkaz:
https://doaj.org/article/73645594ae5140279a19c58876314432
Autor:
Shyny Koshy, Danli Wu, Xueyou Hu, Rajeev B Tajhya, Redwan Huq, Fatima S Khan, Michael W Pennington, Heike Wulff, Patricia Yotnda, Christine Beeton
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76740 (2013)
Natural killer (NK) cells are large granular lymphocytes that participate in both innate and adaptive immune responses against tumors and pathogens. They are also involved in other conditions, including organ rejection, graft-versus-host disease, rec
Externí odkaz:
https://doaj.org/article/9d49b71d5a4e498ba0b089b1c075835f