Zobrazeno 1 - 10
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pro vyhledávání: '"Christine Beedham"'
Autor:
Christine Beedham
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 50(1)
Despite expanding knowledge on the structure and reactivity of human aldehyde oxidase (hAOX1) many drugs enter human studies only to be removed from further clinical trials due to aldehyde oxidase (AOX)-catalysed metabolism.In addition to oxidation o
Publikováno v:
Pharmacology. 73:199-208
Aromatic aldehydes are good substrates of aldehyde dehydrogenase activity but are relatively poor substrates of aldehyde oxidase and xanthine oxidase. However, the oxidation of xenobiotic-derived aromatic aldehydes by the latter enzymes has not been
Publikováno v:
Journal of Medical Sciences. 5:10-20
Publikováno v:
Basic Toxicology. 95:273-279
2-Phenylethylamine is an endogenous constituent of the human brain and is implicated in cerebral transmission. This bioactive amine is also present in certain foodstuffs such as chocolate, cheese and wine and may cause undesirable side effects in sus
Publikováno v:
Acta Biochimica Polonica. 51:649-663
Molybdenum-containing enzymes, aldehyde oxidase and xanthine oxidase, are important in the oxidation of N-heterocyclic xenobiotics. However, the role of these enzymes in the oxidation of drug-derived aldehydes has not been established. The present in
Publikováno v:
Scopus-Elsevier
2-Phenylethylamine is an endogenous constituent of human brain and is implicated in cerebral transmission. It is also found in certain foodstuffs and may cause toxic side-effects in susceptible individuals. Metabolism of 2-phenylethylamine to phenyla
Publikováno v:
The Journal of Clinical Pharmacology. 44:7-19
The authors tested 239 frequently used drugs and other compounds for their potential to inhibit the drug-metabolizing enzyme, aldehyde oxidase, in human liver cytosol. A sensitive, moderate throughput HPLC-MS assay was developed for 1-phthalazinone,
Publikováno v:
Journal of Clinical Psychopharmacology. 23:229-232
Ziprasidone (Geodon, Zeldox), a recently approved atypical antipsychotic agent for the treatment of schizophrenia, undergoes extensive metabolism in humans with very little (
Autor:
S. E. Clarke, Christine Beedham, H. Laljee, C. G. M. Jordan, Mohammad-Reza Rashidi, J. E. Brown
Publikováno v:
Journal of Pharmacy and Pharmacology. 51:411-418
Although 7-hydroxymethotrexate is a major metabolite of methotrexate during high-dose therapy, negligible methotrexate-oxidizing activity has been found in-vitro in the liver in man. The goals of this study were to determine the role of aldehyde oxid
Autor:
Christine Beedham
Publikováno v:
Pharmacy World and Science. 19:255-263
In addition to cytochrome P450, oxidation of drugs and other xenobiotics can also be mediated by non–P450 enzymes, the most significant of which are flavin monooxygenase, monoamine oxidase, alcohol dehydrogenase, aldehyde dehydrogenase, aldehyde ox