Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Christine B. Beuschel"'
Publikováno v:
PLoS Biology, Vol 20, Iss 12 (2022)
The brain as a central regulator of stress integration determines what is threatening, stores memories, and regulates physiological adaptations across the aging trajectory. While sleep homeostasis seems to be linked to brain resilience, how age-assoc
Externí odkaz:
https://doaj.org/article/b3bbeba944aa463bb995062cec0c52ae
Autor:
YongTian Liang, Chengji Piao, Christine B. Beuschel, David Toppe, Laxmikanth Kollipara, Boris Bogdanow, Marta Maglione, Janine Lützkendorf, Jason Chun Kit See, Sheng Huang, Tim O.F. Conrad, Ulrich Kintscher, Frank Madeo, Fan Liu, Albert Sickmann, Stephan J. Sigrist
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108941- (2021)
Summary: Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown to promote mitoch
Externí odkaz:
https://doaj.org/article/973855efe1694596aa789d1da04bdb4d
Autor:
Mathias A. Böhme, Anthony W. McCarthy, Andreas T. Grasskamp, Christine B. Beuschel, Pragya Goel, Meida Jusyte, Desiree Laber, Sheng Huang, Ulises Rey, Astrid G. Petzoldt, Martin Lehmann, Fabian Göttfert, Pejmun Haghighi, Stefan W. Hell, David Owald, Dion Dickman, Stephan J. Sigrist, Alexander M. Walter
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Synaptic plasticity ensures functionality during perturbations and enables memory formation. Here, the authors describe homeostatic functional and nano-modular active zone modifications for immediate and long-lasting enhancement of neurotransmitter r
Externí odkaz:
https://doaj.org/article/9733b2fe50774e4e995b69653b092187
Autor:
Didac Carmona-Gutierrez, Andreas Zimmermann, Katharina Kainz, Federico Pietrocola, Guo Chen, Silvia Maglioni, Alfonso Schiavi, Jihoon Nah, Sara Mertel, Christine B. Beuschel, Francesca Castoldi, Valentina Sica, Gert Trausinger, Reingard Raml, Cornelia Sommer, Sabrina Schroeder, Sebastian J. Hofer, Maria A. Bauer, Tobias Pendl, Jelena Tadic, Christopher Dammbrueck, Zehan Hu, Christoph Ruckenstuhl, Tobias Eisenberg, Sylvere Durand, Noélie Bossut, Fanny Aprahamian, Mahmoud Abdellatif, Simon Sedej, David P. Enot, Heimo Wolinski, Jörn Dengjel, Oliver Kepp, Christoph Magnes, Frank Sinner, Thomas R. Pieber, Junichi Sadoshima, Natascia Ventura, Stephan J. Sigrist, Guido Kroemer, Frank Madeo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Although ageing is the most important risk factor for chronic ailments, effective interventions remain rare. Here, the authors identify the flavonoid 4,4’-dimethoxychalcone and demonstrate that it extends lifespan and promotes health in multiple or
Externí odkaz:
https://doaj.org/article/5a077fc79ab04bd9a229474d374a66e5
Autor:
Christine B. Beuschel, Marta Maglione, Jennifer Woitkuhn, Sheng Huang, Martin Lehmann, Stephan J. Sigrist, Tanja Matkovic-Rachid, Anatoli Ender, Joerg R.P. Geiger
Publikováno v:
Journal of neurogenetics 34(1), 106-114 (2020). doi:10.1080/01677063.2019.1710146
The cellular analysis of mushroom body (MB)-dependent memory forming processes is far advanced, whereas, the molecular and physiological understanding of their synaptic basis lags behind. Recent analysis of the Drosophila olfactory system showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::116475bbbeee13ce59a27f7004cbb0c3
Autor:
Markus C. Wahl, Ulrich Stelzl, Sunbin Liu, Stephan J. Sigrist, Martin Lehmann, Janine Lützkendorf, Astrid G. Petzoldt, Benno Kuropka, Vladimir Ugorets, Bernhard Loll, Christine B. Beuschel, Niraja Ramesh, Christian Freund, Torsten W.B. Götz, Elena Knoche, Suneel Reddy-Alla, Jan H. Driller, Sara Mertel, Fan Liu, Tanja Matkovic-Rachid
Publikováno v:
The Journal of Cell Biology
The journal of cell biology 219(7), e201902059 (2020). doi:10.1083/jcb.201902059
The journal of cell biology 219(7), e201902059 (2020). doi:10.1083/jcb.201902059
Petzoldt et al. investigate the functional protein architecture at the presynaptic active zone, an elaborate protein scaffold organizing synaptic vesicle (SV) release. They find that the conserved multidomain protein RIM-BP provides a relay to guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948e8ac8657ae792620e23b748e81ed2
http://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=102723
http://www.helmholtz-berlin.de/pubbin/oai_publication?VT=1&ID=102723
Autor:
Christine B. Beuschel, Fan Liu, Boris Bogdanow, Tim Conrad, Frank Madeo, Ulrich Kintscher, Stephan J. Sigrist, YongTian Liang, Marta Maglione, Janine Lützkendorf, Jason Chun Kit See, David Toppe, Sheng Huang, Albert Sickmann, Laxmikanth Kollipara, Chengji Piao
Publikováno v:
Cell Reports, Vol 35, Iss 2, Pp 108941-(2021)
Summary: Mitochondrial function declines during brain aging and is suspected to play a key role in age-induced cognitive decline and neurodegeneration. Supplementing levels of spermidine, a body-endogenous metabolite, has been shown to promote mitoch
Autor:
Anthony W. McCarthy, Christine B. Beuschel, Martin Lehmann, Astrid G. Petzoldt, Stefan W. Hell, Sheng Huang, Pragya Goel, Meida Jusyte, Stephan J. Sigrist, Dion Dickman, Andreas T. Grasskamp, Desiree Laber, Ulises Rey, Alexander M. Walter, Fabian Goettfert, David Owald, Pejmun Haghighi, Mathias A. Böhme
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Neuronal communication across synapses relies on neurotransmitter release from presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic plasticity homeostatically maintains functionality during perturbations and enables
Autor:
Christine B. Beuschel, Frank Madeo, Stephan J. Sigrist, Anuradha Bhukel, Gábor Juhász, Martin Lehmann, Marta Maglione
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Macroautophagy is an evolutionarily conserved cellular maintenance program, meant to protect the brain from premature aging and neurodegeneration. How neuronal autophagy, usually loosing efficacy with age, intersects with neuronal processes mediating
Publikováno v:
Current Biology. 30:1077-1091.e5
Sleep is universal across species and essential for quality of life and health, as evidenced by the consequences of sleep loss. Sleep might homeostatically normalize synaptic gains made over wake states in order to reset information processing and st