Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christine Arrabit"'
Autor:
Joshua Tan, John R. Yates, Carlos Arias, Paul E. Sawchenko, Christine Arrabit, Paul A. Slesinger, Marie-Louise Lunn, Ian McLeod, Rounak Nassirpour
Publikováno v:
Nature Neuroscience. 10:1249-1259
G protein-gated potassium (Kir3) channels are important for controlling neuronal excitability in the brain. Using a proteomics approach, we have identified a unique rodent intracellular protein, sorting nexin 27 (SNX27), which regulates the trafficki
Publikováno v:
The Journal of General Physiology
Steeply voltage-dependent block by intracellular polyamines underlies the strong inward rectification properties of Kir2.1 and other Kir channels. Mutagenesis studies have identified several negatively charged pore-lining residues (D172, E224, and E2
Publikováno v:
Biochemistry. 45:8599-8606
Kir2.1 channels play a key role in maintaining the correct resting potential in eukaryotic cells. Recently, specific amino acid mutations in the Kir2.1 inwardly rectifying potassium channel have been found to cause Andersen's Syndrome in humans. Here
Publikováno v:
Journal of Biological Chemistry. 279:28149-28158
Ligand-gated ion channel receptors mediate the response of fast neurotransmitters by opening in less than a millisecond. Here, we investigated the activation mechanism of a serotonin-gated receptor (5-HT3A) by systematically introducing cysteine subs
Publikováno v:
The Journal of Physiology. 555:643-657
The activity of G protein-activated inwardly rectifying K+ channels (GIRK or Kir3) is important for regulating membrane excitability in neuronal, cardiac and endocrine cells. Although Gβγ subunits are known to bind the N- and C-termini of GIRK chan
Publikováno v:
The Journal of Neuroscience. 22:1629-1639
Serotonin-gated ion channels (5-HT3) are members of the ligand-gated channel family, which includes channels that are opened directly by the neurotransmitter acetylcholine, GABA, glycine, or glutamate. Although there is general agreement that the sec
Autor:
Bernadette Beau, Jean-Claude Murat, Jean-Pierre Soleilhavoup, Françoise Croute, Yolande Gaubin, Florence Delmas, Christine Arrabit
Publikováno v:
Environmental Health Perspectives
Exposure to cadmium is associated with the development of pulmonary damage such as emphysema and lung cancer. This metal is also a powerful inducer of stress proteins in many biologic models. The present study was undertaken to evaluate whether an ov
Autor:
Sinead M. Clancy, Melissa Finley, Frédérique Berton, Christine Arrabit, Patrick J. Casey, Paul A. Slesinger, Tohru Kosaza, Catherine E. Fowler, Ka Fai Suen
Publikováno v:
Molecular and cellular neurosciences. 28(2)
Neuronal G-protein-gated inwardly rectifying potassium (Kir3; GIRK) channels are activated by G-protein-coupled receptors that selectively interact with PTX-sensitive (Galphai/o) G proteins. Although the Gbetagamma dimer is known to activate GIRK cha
Publikováno v:
The Journal of physiology. 555(Pt 3)
The activity of G protein-activated inwardly rectifying K(+) channels (GIRK or Kir3) is important for regulating membrane excitability in neuronal, cardiac and endocrine cells. Although G(betagamma) subunits are known to bind the N- and C-termini of
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 98(11)
Local anesthetics, commonly used for treating cardiac arrhythmias, pain, and seizures, are best known for their inhibitory effects on voltage-gated Na + channels. Cardiovascular and central nervous system toxicity are unwanted side-effects from local