Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Christine Alewine"'
Autor:
Nebojsa Skorupan, Cody J. Peer, Xianyu Zhang, Hyoyoung Choo-Wosoba, Mehwish I. Ahmad, Min-Jung Lee, Shraddha Rastogi, Nahoko Sato, Yunkai Yu, Guillaume Joe Pegna, Seth M. Steinberg, Shelley S. Kalsi, Liang Cao, William D. Figg, Jane B. Trepel, Ira Pastan, David FitzGerald, Christine Alewine
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
BackgroundLMB-100 is a mesothelin (MSLN)-targeting recombinant immunotoxin (iTox) carrying a Pseudomonas exotoxin A payload that has shown promise against solid tumors, however, efficacy is limited by the development of neutralizing anti-drug antibod
Externí odkaz:
https://doaj.org/article/7b50e02d4e8d4d54b44bd8cfb4b2d620
Autor:
Guillaume Joe Pegna, Min‐Jung Lee, Cody J. Peer, Mehwish I. Ahmad, David J. Venzon, Yunkai Yu, Akira Yuno, Seth M. Steinberg, Liang Cao, William D. Figg, Renee N. Donahue, Raffit Hassan, Ira Pastan, Jane B. Trepel, Christine Alewine
Publikováno v:
Cancer Medicine, Vol 12, Iss 4, Pp 4236-4249 (2023)
Abstract LMB‐100 is a novel immune‐conjugate (immunotoxin) that targets mesothelin. A phase 1/2 clinical trial was conducted (NCT02810418) with primary objectives assessing the safety and efficacy of LMB‐100 ± nab‐paclitaxel. Participant blo
Externí odkaz:
https://doaj.org/article/b0426dc9f76e4ee5ac65fe73a10166c9
Publikováno v:
Cancer Communications, Vol 42, Iss 3, Pp 269-272 (2022)
Externí odkaz:
https://doaj.org/article/0293a5d9ae8246f7b724bcccc4d39cd1
Autor:
Xianyu Zhang, Yunkai Yu, Cody J. Peer, Rebekah Landsman, Nebojsa Skorupan, Liang Cao, Christine Alewine
Publikováno v:
Translational Oncology, Vol 21, Iss , Pp 101440- (2022)
Mesothelin (MSLN) is overexpressed by many cancers, including pancreatic ductal adenocarcinoma (PDAC) and has consequently become a target for anti-cancer therapeutics. Mature, membrane bound MSLN is cleaved by proteases, releasing a shed form that t
Externí odkaz:
https://doaj.org/article/9fd8099ceea94d9b9d4c45b0e8b8941a
Publikováno v:
Biomolecules, Vol 10, Iss 7, p 973 (2020)
Mesothelin (MSLN) is a cell surface glycoprotein normally expressed only on serosal surfaces, and not found in the parenchyma of vital organs. Many solid tumors also express MSLN, including mesothelioma and pancreatic adenocarcinoma. Due to this favo
Externí odkaz:
https://doaj.org/article/1b905c2ad58a4b77bf8997bee806b742
Autor:
Salma El-Behaedi, Rebekah Landsman, Michael Rudloff, Emily Kolyvas, Rakan Albalawy, Xianyu Zhang, Tapan Bera, Keith Collins, Serguei Kozlov, Christine Alewine
Publikováno v:
Toxins, Vol 10, Iss 11, p 447 (2018)
LMB-100 is a mesothelin-targeted recombinant immunotoxin (iTox) that carries a modified Pseuodomonas exotoxin A (PE) payload. PE kills cells by inhibiting synthesis of new proteins. We found that treatment of pancreatic cancer cells with LMB-100 for
Externí odkaz:
https://doaj.org/article/e47a4c7aef404df6a5836a10122e6bf1
Autor:
Jingli Zhang, Tapan K Bera, Wenhai Liu, Xing Du, Christine Alewine, Raffit Hassan, Ira Pastan
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104388 (2014)
The mesothelin (MSLN) gene encodes a 71 kilodalton (kDa) precursor protein that is processed into megakaryocytic potentiating factor (MPF), a 31 kDa protein that is secreted from the cell, and mature mesothelin (mMSLN), a 40 kDa cell surface protein.
Externí odkaz:
https://doaj.org/article/d49ea85e129e4e92a364cff765c30e07
Systemic immune changes accompany combination treatment with immunotoxin LMB ‐100 and nab‐paclitaxel
Autor:
Guillaume Joe Pegna, Min‐Jung Lee, Cody J. Peer, Mehwish I. Ahmad, David J. Venzon, Yunkai Yu, Akira Yuno, Seth M. Steinberg, Liang Cao, William D. Figg, Renee N. Donahue, Raffit Hassan, Ira Pastan, Jane B. Trepel, Christine Alewine
Publikováno v:
Cancer Medicine. 12:4236-4249
LMB-100 is a novel immune-conjugate (immunotoxin) that targets mesothelin. A phase 1/2 clinical trial was conducted (NCT02810418) with primary objectives assessing the safety and efficacy of LMB-100 ± nab-paclitaxel. Participant blood samples were a
Autor:
Ira Pastan, Klaus Bosslet, Gerhard Niederfellner, Takao Yamori, Laiman Xiang, Christine Alewine
Supplementary Figure 2. Demonstrates no activity of a control non-binding immunotoxin in vitro and in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f436a7217bf03d95373a8c7bd2846b
https://doi.org/10.1158/1535-7163.22502506
https://doi.org/10.1158/1535-7163.22502506
Autor:
Christine Alewine, Xianyu Zhang, Xiongfong Chen, Rakan Albalawy, Danielle Arons, Salma El-Behaedi, Michael Rudloff, Leela Rani Avula
Figure Legends and Supplementary Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1faac0ba5a245982ae903589fc46ba99
https://doi.org/10.1158/1541-7786.22517979.v1
https://doi.org/10.1158/1541-7786.22517979.v1