Výsledky vyhledávání - "Christine A. Sikora"

Mitochondrial Localization of Superoxide Dismutase is Required for Decreasing Radiation-Induced Cellular Damage

Autor: Joel S. Greenberger, Joan Gretton, Mia Jefferson, Michael W. Epperly, M Bernarding, Suhua Nie, Christine A. Sikora

Publikováno v: Radiation Research. 160:568-578

We investigated the importance of mitochondrial localization of the SOD2 (MnSOD) transgene product for protection of 32D cl 3 hematopoietic cells from radiation-induced killing. Four plasmids containing (1) the native human copper/zinc superoxide dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081c4d5e69cb892d6fba93196ceb316d
https://doi.org/10.1667/rr3081

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Intratracheal injection of manganese superoxide dismutase (MnSOD) plasmid/liposomes protects normal lung but not orthotopic tumors from irradiation

Autor: S.J Defilippi, Michael W. Epperly, A.M. Kalend, Joel S. Greenberger, J. Gretton, Christine A. Sikora

Publikováno v: Gene Therapy. 7:1011-1018

To determine whether intratracheal (IT) lung protective manganese superoxide-plasmid/liposomes (MnSOD-PL) complex provided 'bystander' protection of thoracic tumors, mice with orthotopic Lewis lung carcinoma-bacterial beta-galactosidase gene (3LL-Lac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0687bc351b5c34a274458ae7dcde0c7
https://doi.org/10.1038/sj.gt.3301207

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Plasmid/liposome transfer of the human manganese superoxide dismutase transgene prevents ionizing irradiation-induced apoptosis in human esophagus organ explant culture

Autor: S.J Defilippi, Denny Liggitt, Gary Koe, Joel S. Greenberger, James D. Luketich, Christine A. Sikora, Michael W. Epperly, J. Bray

Publikováno v: International Journal of Cancer. 90:128-137

Esophagitis is a major limiting factor in the treatment of lung cancer by radiation alone or in combination with chemotherapy. We have previously demonstrated that intraesophageal injection of manganese superoxide dismutase–plasmid/liposome (MnSOD�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8eaac729d88efa63bee81015f718c648
https://doi.org/10.1002/1097-0215(20000620)90:3<128::aid-ijc2>3.0.co

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Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis

Autor: Joel S. Greenberger, Elizabeth L. Travis, Michael W. Epperly, Christine A. Sikora

Publikováno v: Biology of Blood and Marrow Transplantation. 5(4):204-214

Radiation pneumonitis remains a critical dose-limiting toxicity of total body irradiation (TBI) for use in bone marrow transplantation. The acute and chronic phases of radiation damage in the mouse lung have been shown to correlate with mouse strain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c013d48aa6be6cea98b5593c6926eae9

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Bone marrow origin of cells with capacity for homing and differentiation to esophageal squamous epithelium

Autor: Hongmei Shen, Xichen Zhang, Christine A. Sikora, Joel S. Greenberger, Michael W. Epperly, Yunyun Niu, Mia Jefferson, Hongliang Guo

Publikováno v: Radiation research. 162(3)

Our goal was to determine whether esophageal progenitor cells could be isolated from adult mouse esophagus or bone marrow and shown to home to and proliferate in the irradiated esophagus of recipient mice. Esophageal progenitor cells were isolated fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef4b0d6d478ca1c713502e1c2980798
https://pubmed.ncbi.nlm.nih.gov/15333000

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Manganese superoxide dismutase (SOD2) inhibits radiation-induced apoptosis by stabilization of the mitochondrial membrane

Autor: Qimin Zhan, Joel S. Greenberger, Michael W. Epperly, S.J Defilippi, J. Gretton, Christine A. Sikora, Donald Kufe

Publikováno v: Radiation research. 157(5)

To define the molecular pathways involved in radiation-induced apoptosis and the role of the mitochondria, 32D cl 3 hematopoietic cells and subclones overexpressing either the human manganese superoxide dismutase (SOD2) transgene (1F2 and 2C6) or BCL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c61675e2720dfaefdf993b2a5f3348
https://pubmed.ncbi.nlm.nih.gov/11966323

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Manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) administration protects mice from esophagitis associated with fractionated radiation

Autor: S.J Defilippi, Joel S. Greenberger, Valerian E. Kagan, Dapha Bar-Sagi, Michael W. Epperly, Joan Gretton, Christine A. Sikora

Publikováno v: International journal of cancer. 96(4)

Intraesophageal administration of manganese superoxide dismutase-plasmid/liposome (MnSOD-PL) prior to single fraction radiation has been shown to protect mice from lethal esophagitis. In our study, C3H/HeNsd mice received fractionated radiation in tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b7e87b829034bcf1b3377aa796a363
https://pubmed.ncbi.nlm.nih.gov/11474496

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Modulation of radiation-induced cytokine elevation associated with esophagitis and esophageal stricture by manganese superoxide dismutase-plasmid/liposome (SOD2-PL) gene therapy

Autor: Christine A. Sikora, S.J Defilippi, Joel S. Greenberger, J. Gretton, Michael W. Epperly, Denny Liggitt, Gary Koe

Publikováno v: Radiation research. 155(1 Pt 1)

Radiation of the esophagus of C3H/HeNsd mice with 35 or 37 Gy of 6 MV X rays induces significantly increased RNA transcription for interleukin 1 (Il1), tumor necrosis factor alpha (Tnf), interferon gamma inducing factor (Ifngr), and interferon gamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3c62e40ccc66463f1e9e2738f49c36
https://pubmed.ncbi.nlm.nih.gov/11121210

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