Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christine A. Penfold"'
Autor:
Franziska Heckel, Anna H. Turaj, Hayden Fisher, H. T. Claude Chan, Michael J. E. Marshall, Osman Dadas, Christine A. Penfold, Tatyana Inzhelevskaya, C. Ian Mockridge, Diego Alvarado, Ivo Tews, Tibor Keler, Stephen A. Beers, Mark S. Cragg, Sean H. Lim
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Agonistic CD27 monoclonal antibodies can be used to enhance the efficacy of depleting antibodies such as anti-CTLA-4 in a colon adenocarcinoma tumour model. CD27 antibody agonism is dependent on isotype and epitope specificity.
Externí odkaz:
https://doaj.org/article/f7e2de2c168f4f2984754369dc482291
Autor:
Xiaojie Yu, Sonya James, James H. Felce, Blanka Kellermayer, David A. Johnston, H. T. Claude Chan, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Yasunori Watanabe, Max Crispin, Ruth R. French, Patrick J. Duriez, Leon R. Douglas, Martin J. Glennie, Mark S. Cragg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Yu et al examined a panel of both experimental and clinically-relevant TNF agonists in order to advance our understanding of the mechanisms underlying their varying activities and anti-tumor responses. They demonstrated that agonists with greater act
Externí odkaz:
https://doaj.org/article/497b996aa1574d6a946f5ee6787fec3f
Autor:
Aymen Al-Shamkhani, Tibor Keler, Michael A. Curran, Li-Zhen He, Christine A. Penfold, Lawrence J. Thomas, Anne Rogel, Vadim Y. Taraban, Stephen M. Thirdborough, Mohannad Fallatah, Sarah L. Buchan
List of genes represented in the heatmap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee1e3176da46315bf43afa406a82809
https://doi.org/10.1158/1078-0432.22464095.v1
https://doi.org/10.1158/1078-0432.22464095.v1
Autor:
Aymen Al-Shamkhani, Tibor Keler, Michael A. Curran, Li-Zhen He, Christine A. Penfold, Lawrence J. Thomas, Anne Rogel, Vadim Y. Taraban, Stephen M. Thirdborough, Mohannad Fallatah, Sarah L. Buchan
Purpose: PD-1 checkpoint blockade has revolutionized the field of cancer immunotherapy, yet the frequency of responding patients is limited by inadequate T-cell priming secondary to a paucity of activatory dendritic cells (DC). DC signals can be bypa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eea76d6421bd3b7528bc593d3913fdc
https://doi.org/10.1158/1078-0432.c.6525617
https://doi.org/10.1158/1078-0432.c.6525617
Autor:
Aymen Al-Shamkhani, Tibor Keler, Michael A. Curran, Li-Zhen He, Christine A. Penfold, Lawrence J. Thomas, Anne Rogel, Vadim Y. Taraban, Stephen M. Thirdborough, Mohannad Fallatah, Sarah L. Buchan
Figure S1: Agonist anti-CD27 is superior to other anti-TNFRSF mAbs for CD8+ T-cell expansion in vivo; Figure S2: Agonist anti-CD27 and PD-1/L1 blockade combine to promote expansion of OT-I T cells in response to high and low affinity peptides; Figure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07808cca2e7e112e0913f9fe288f5dac
https://doi.org/10.1158/1078-0432.22464101.v1
https://doi.org/10.1158/1078-0432.22464101.v1
Autor:
Xiaojie Yu, Christian M. Orr, H. T. Claude Chan, Sonya James, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Kerry L. Cox, Jonathan W. Essex, Ivo Tews, Martin J. Glennie, Mark S. Cragg
Antibody responses during infection and vaccination typically undergo affinity maturation to achieve high-affinity binding for efficient neutralization of pathogens1,2. Similarly, high affinity is routinely the goal for therapeutic antibody generatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3413a611d84ceac2eb9f01db8758a17
https://eprints.soton.ac.uk/475620/
https://eprints.soton.ac.uk/475620/
Autor:
Mark S. Cragg, H.T. Claude Chan, Max Crispin, David A. Johnston, Martin J. Glennie, James H Felce, Leon Douglas, C. Ian Mockridge, Sonya James, Jinny Kim, Xiaojie Yu, Ruth R. French, Christine A. Penfold, Tatyana Inzhelevskaya, Yasunori Watanabe, Patrick J. Duriez, Blanka Kellermayer
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biology
Communications Biology
Monoclonal antibodies (mAb) and natural ligands targeting costimulatory tumor necrosis factor receptors (TNFR) exhibit a wide range of agonistic activities and antitumor responses. The mechanisms underlying these differential agonistic activities rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b17224ce36635b86b6bad1a9401509
https://doaj.org/article/497b996aa1574d6a946f5ee6787fec3f
https://doaj.org/article/497b996aa1574d6a946f5ee6787fec3f
Autor:
Christian M. Orr, Hayden Fisher, Xiaojie Yu, Claude H.-T. Chan, Yunyun Gao, Patrick J. Duriez, Steven G. Booth, Isabel Elliott, Tatyana Inzhelevskaya, Ian Mockridge, Christine A. Penfold, Armin Wagner, Martin J. Glennie, Ann L. White, Jonathan W. Essex, Arwen R. Pearson, Mark S. Cragg, Ivo Tews
Publikováno v:
Science Immunology
Antibodies protect from infection, underpin successful vaccines and elicit therapeutic responses in otherwise untreatable cancers and autoimmune conditions. The human IgG2 isotype displays a unique capacity to undergo disulfide shuffling in the hinge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f26559ffaad774e3100f8f5c38f54b
https://pubmed.ncbi.nlm.nih.gov/35857582
https://pubmed.ncbi.nlm.nih.gov/35857582
Autor:
Julia Moreno-Vicente, Jane E Willoughby, Martin C Taylor, Steven G Booth, Vikki L English, Emily L Williams, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Jinny Kim, H T Claude Chan, Mark S Cragg, Juliet C Gray, Stephen A Beers
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundDespite extensive clinical use, the mechanisms that lead to therapeutic resistance to anti-programmed cell-death (PD)-1 monoclonal antibodies (mAbs) remain elusive. Here, we sought to determine how interactions between the Fc region of anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc1d40f038ae30462935179ccdb7a35
https://jitc.bmj.com/content/10/1/e003735.full
https://jitc.bmj.com/content/10/1/e003735.full
Autor:
Marcus A Widdess, H. T. Claude Chan, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Hannah J Metcalfe, Mark S Cragg, Aymen Al-Shamkhani
Publikováno v:
Cancer Immunology Research. 10:A26-A26
Immunostimulatory antibodies targeting co-stimulatory TNFRSF members have shown promise in pre-clinical cancer models, but this has not translated into clinical success, primarily due to lack of efficacy. Oligomerisation of the co-stimulatory molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ef1cdf69b6b27eb52c8682950ade4ed
https://doi.org/10.1158/2326-6074.tumimm22-a26
https://doi.org/10.1158/2326-6074.tumimm22-a26