Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christine A. Parachoniak"'
Autor:
Julien Fitamant, Filippos Kottakis, Samira Benhamouche, Helen S. Tian, Nicolas Chuvin, Christine A. Parachoniak, Julia M. Nagle, Rushika M. Perera, Marjorie Lapouge, Vikram Deshpande, Andrew X. Zhu, Albert Lai, Bosun Min, Yujin Hoshida, Joseph Avruch, Daniela Sia, Genís Campreciós, Andrea I. McClatchey, Josep M. Llovet, David Morrissey, Lakshmi Raj, Nabeel Bardeesy
Publikováno v:
Cell Reports, Vol 10, Iss 10, Pp 1692-1707 (2015)
Defective Hippo/YAP signaling in the liver results in tissue overgrowth and development of hepatocellular carcinoma (HCC). Here, we uncover mechanisms of YAP-mediated hepatocyte reprogramming and HCC pathogenesis. YAP functions as a rheostat in maint
Externí odkaz:
https://doaj.org/article/0668dfdac5754c879ffbfed4d6e834b3
Autor:
Hatim Husain, Dean C. Pavlick, Bernard J. Fendler, Russell W. Madison, Brennan Decker, Ole Gjoerup, Christine A. Parachoniak, Molly McLaughlin-Drubin, Rachel L. Erlich, Alexa B. Schrock, Garrett M. Frampton, Meghna Das Thakur, Geoffrey R. Oxnard, Hanna Tukachinsky
Publikováno v:
JCO Precis Oncol
PURPOSE Profiling of circulating tumor DNA (ctDNA) is increasingly adopted in the management of solid tumors, concurrent with increased availability of more comprehensive ctDNA panels. However, variable ctDNA shed can result in variable assay sensiti
Autor:
Michael E. Goldberg, Phillip J. Stephens, Aju Mathew, Peter C. Lucas, John Cho, Siraj M. Ali, Ryan J. Hartmaier, Margaret Rosenzweig, Jennifer M. Atkinson, Rena D. Callahan, C Williams, P. Vanden Borre, Ben Ho Park, Z. Erdogan-Yildirim, J.S. Ross, Brandon Young, G.M. Frampton, M. Tsai, Adam Brufsky, Adrian V. Lee, Jon Chung, Juliann Chmielecki, Shannon Puhalla, Rebecca J. Watters, Christine A. Parachoniak, L. Cao, Sally E. Trabucco, James Suh, Samantha Morley, N. E. Davidson, Nolan Priedigkeit, Julio Peguero, I. Sachelarie, Amir Bahreini, Steffi Oesterreich, Barbara Haley, Alison M. Nagle, Brian Leyland-Jones
Publikováno v:
Annals of Oncology
Background Estrogen receptor-positive (ER-positive) metastatic breast cancer is often intractable due to endocrine therapy resistance. Although ESR1 promoter switching events have been associated with endocrine-therapy resistance, recurrent ESR1 fusi
Autor:
Hanna Tukachinsky, Garrett M. Frampton, Ole Gjoerup, Emmanuel S. Antonarakis, Jeffrey M. Venstrom, Zheng Kuang, Aparna Aiyer, Eric Allan Severson, Geoffrey R. Oxnard, Andrew Kelly, Christine A. Parachoniak, Dean Pavlick
Publikováno v:
Journal of Clinical Oncology. 39:3009-3009
3009 Background: The increased use of ctDNA CGP has paralleled increased detection and interest in CH, which can confound CGP results from ctDNA or tissue, and can be associated with hematologic and cardiovascular morbidity. However, paired-depth seq
Autor:
Lisa Pei, Chu, Debra, Franck, Christine A, Parachoniak, Jeffrey P, Gregg, Michael G, Moore, D Gregory, Farwell, Shyam, Rao, Andreas M, Heilmann, Rachel L, Erlich, Jeffrey S, Ross, Vincent A, Miller, Siraj, Ali, Jonathan W, Riess
Publikováno v:
The oncologist. 24(10)
Identification of effective targeted therapies for recurrent/metastatic head and neck squamous cell carcinoma (HNSCC) remains an unmet medical need. A patient with platinum‐refractory recurrent oral cavity HNSCC underwent comprehensive genomic prof
Publikováno v:
Traffic. 17:670-688
The integrin family of cell adhesion receptors link extracellular matrices to intracellular signaling pathways and the actin cytoskeleton; and regulate cell migration, proliferation and survival in normal and diseased tissues. The subcellular locatio
Publikováno v:
Traffic (Copenhagen, Denmark)
Endocytic sorting of activated receptor tyrosine kinases (RTKs), alternating between recycling and degradative processes, controls signal duration, location and surface complement of RTKs. The microtubule (MT) plus-end tracking proteins (+TIPs) play
Autor:
Juliann Chmielecki, Ryan J. Hartmaier, Vincent A. Miller, Jeffrey S. Ross, Phil Stephens, Rachel L. Erlich, Christine A. Parachoniak, Bernadette Gaffney, John Keech, Deborah Morosini, Andrew Rankin, Dan Spritz
Publikováno v:
Cold Spring Harbor Molecular Case Studies
Metastatic triple-negative breast cancer comprises 12%–17% of breast cancers and carries a poor prognosis relative to other breast cancer subtypes. Treatment options in this disease are largely limited to systemic chemotherapy. A majority of clinic
Autor:
Morag Park, Kan V. Lu, Manish K. Aghi, Joanna J. Phillips, David A. Cheresh, Jeffrey P. Chang, Melissa M. Pandika, Shaun D. Fouse, Nadezhda Isachenko, Christine A. Parachoniak, David Meyronet, Gabriele Bergers
Publikováno v:
Cancer cell, vol 22, iss 1
SummaryInhibition of VEGF signaling leads to a proinvasive phenotype in mouse models of glioblastoma multiforme (GBM) and in a subset of GBM patients treated with bevacizumab. Here, we demonstrate that vascular endothelial growth factor (VEGF) direct
Autor:
Christine A. Parachoniak, Morag Park
Publikováno v:
Trends in Cell Biology. 22:231-240
The transport and sorting of cell surface receptors into membrane-bound intracellular compartments is crucial for cellular homeostasis. Defects in receptor trafficking are associated with several diseases, including cancer. Recent advances in our und