Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Christine A. Orengo"'
Autor:
Vaishali P. Waman, Paul Ashford, Su Datt Lam, Neeladri Sen, Mahnaz Abbasian, Laurel Woodridge, Yonathan Goldtzvik, Nicola Bordin, Jiaxin Wu, Ian Sillitoe, Christine A. Orengo
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-19 (2024)
Abstract The COVID-19 disease is an ongoing global health concern. Although vaccination provides some protection, people are still susceptible to re-infection. Ostensibly, certain populations or clinical groups may be more vulnerable. Factors causing
Externí odkaz:
https://doaj.org/article/605cb58ddbd04446aebe2817798cb034
Autor:
Tolulope Adeyelu, Nicola Bordin, Vaishali P. Waman, Marta Sadlej, Ian Sillitoe, Aurelio A. Moya-Garcia, Christine A. Orengo
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 277 (2023)
Protein kinases are important targets for treating human disorders, and they are the second most targeted families after G-protein coupled receptors. Several resources provide classification of kinases into evolutionary families (based on sequence ho
Externí odkaz:
https://doaj.org/article/61ece3c01e2b445daa1171daf779add8
Autor:
Naihui Zhou, Yuxiang Jiang, Timothy R. Bergquist, Alexandra J. Lee, Balint Z. Kacsoh, Alex W. Crocker, Kimberley A. Lewis, George Georghiou, Huy N. Nguyen, Md Nafiz Hamid, Larry Davis, Tunca Dogan, Volkan Atalay, Ahmet S. Rifaioglu, Alperen Dalkıran, Rengul Cetin Atalay, Chengxin Zhang, Rebecca L. Hurto, Peter L. Freddolino, Yang Zhang, Prajwal Bhat, Fran Supek, José M. Fernández, Branislava Gemovic, Vladimir R. Perovic, Radoslav S. Davidović, Neven Sumonja, Nevena Veljkovic, Ehsaneddin Asgari, Mohammad R.K. Mofrad, Giuseppe Profiti, Castrense Savojardo, Pier Luigi Martelli, Rita Casadio, Florian Boecker, Heiko Schoof, Indika Kahanda, Natalie Thurlby, Alice C. McHardy, Alexandre Renaux, Rabie Saidi, Julian Gough, Alex A. Freitas, Magdalena Antczak, Fabio Fabris, Mark N. Wass, Jie Hou, Jianlin Cheng, Zheng Wang, Alfonso E. Romero, Alberto Paccanaro, Haixuan Yang, Tatyana Goldberg, Chenguang Zhao, Liisa Holm, Petri Törönen, Alan J. Medlar, Elaine Zosa, Itamar Borukhov, Ilya Novikov, Angela Wilkins, Olivier Lichtarge, Po-Han Chi, Wei-Cheng Tseng, Michal Linial, Peter W. Rose, Christophe Dessimoz, Vedrana Vidulin, Saso Dzeroski, Ian Sillitoe, Sayoni Das, Jonathan Gill Lees, David T. Jones, Cen Wan, Domenico Cozzetto, Rui Fa, Mateo Torres, Alex Warwick Vesztrocy, Jose Manuel Rodriguez, Michael L. Tress, Marco Frasca, Marco Notaro, Giuliano Grossi, Alessandro Petrini, Matteo Re, Giorgio Valentini, Marco Mesiti, Daniel B. Roche, Jonas Reeb, David W. Ritchie, Sabeur Aridhi, Seyed Ziaeddin Alborzi, Marie-Dominique Devignes, Da Chen Emily Koo, Richard Bonneau, Vladimir Gligorijević, Meet Barot, Hai Fang, Stefano Toppo, Enrico Lavezzo, Marco Falda, Michele Berselli, Silvio C.E. Tosatto, Marco Carraro, Damiano Piovesan, Hafeez Ur Rehman, Qizhong Mao, Shanshan Zhang, Slobodan Vucetic, Gage S. Black, Dane Jo, Erica Suh, Jonathan B. Dayton, Dallas J. Larsen, Ashton R. Omdahl, Liam J. McGuffin, Danielle A. Brackenridge, Patricia C. Babbitt, Jeffrey M. Yunes, Paolo Fontana, Feng Zhang, Shanfeng Zhu, Ronghui You, Zihan Zhang, Suyang Dai, Shuwei Yao, Weidong Tian, Renzhi Cao, Caleb Chandler, Miguel Amezola, Devon Johnson, Jia-Ming Chang, Wen-Hung Liao, Yi-Wei Liu, Stefano Pascarelli, Yotam Frank, Robert Hoehndorf, Maxat Kulmanov, Imane Boudellioua, Gianfranco Politano, Stefano Di Carlo, Alfredo Benso, Kai Hakala, Filip Ginter, Farrokh Mehryary, Suwisa Kaewphan, Jari Björne, Hans Moen, Martti E.E. Tolvanen, Tapio Salakoski, Daisuke Kihara, Aashish Jain, Tomislav Šmuc, Adrian Altenhoff, Asa Ben-Hur, Burkhard Rost, Steven E. Brenner, Christine A. Orengo, Constance J. Jeffery, Giovanni Bosco, Deborah A. Hogan, Maria J. Martin, Claire O’Donovan, Sean D. Mooney, Casey S. Greene, Predrag Radivojac, Iddo Friedberg
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-23 (2019)
Abstract Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. Results Here, we report on the results of the third C
Externí odkaz:
https://doaj.org/article/4c2b017b155b41ceab8d6d078186cafa
Autor:
Cynthia Yu-Wai-Man, Nicholas Owen, Jonathan Lees, Aristides D. Tagalakis, Stephen L. Hart, Andrew R. Webster, Christine A. Orengo, Peng T. Khaw
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Fibrosis-related events play a part in most blinding diseases worldwide. However, little is known about the mechanisms driving this complex multifactorial disease. Here we have carried out the first genome-wide RNA-Sequencing study in human
Externí odkaz:
https://doaj.org/article/5c0371687dca468ab80f8f19c7cf2ac1
Autor:
Typhaine Paysan-Lafosse, Matthias Blum, Sara Chuguransky, Tiago Grego, Beatriz Lázaro Pinto, Gustavo A Salazar, Maxwell L Bileschi, Peer Bork, Alan Bridge, Lucy Colwell, Julian Gough, Daniel H Haft, Ivica Letunić, Aron Marchler-Bauer, Huaiyu Mi, Darren A Natale, Christine A Orengo, Arun P Pandurangan, Catherine Rivoire, Christian J A Sigrist, Ian Sillitoe, Narmada Thanki, Paul D Thomas, Silvio C E Tosatto, Cathy H Wu, Alex Bateman
Publikováno v:
Nucleic Acids Research. 51:D418-D427
The InterPro database (https://www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. Here, we report recent developments with InterPro (v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153bbcbf1ab56d7f060b0d1aec9c1f19
https://doi.org/10.1093/nar/gkac993
https://doi.org/10.1093/nar/gkac993
Publikováno v:
Current Opinion in Structural Biology. 70:108-122
Understanding the mechanisms of protein function is indispensable for many biological applications, such as protein engineering and drug design. However, experimental annotations are sparse, and therefore, theoretical strategies are needed to fill th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0841b21f276e3bd6601facc669983ebc
https://doi.org/10.1016/j.sbi.2021.05.012
https://doi.org/10.1016/j.sbi.2021.05.012
Autor:
Mihaly Varadi, Vincent Zoete, Sameer Velankar, Neeladri Sen, Antoine Daina, Shoshana J. Wodak, Christine A. Orengo, Vaishali P Waman
Publikováno v:
Briefings in Bioinformatics
SARS-CoV-2 is the causative agent of COVID-19, the ongoing global pandemic. It has posed a worldwide challenge to human health as no effective treatment is currently available to combat the disease. Its severity has led to unprecedented collaborative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c71b328701cb7a96dbde6a36dd3e6c
https://doi.org/10.1093/bib/bbaa362
https://doi.org/10.1093/bib/bbaa362
Publikováno v:
Bioinformatics (Oxford, England).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7934ec943d4a745af5c7764899d5c498
https://pubmed.ncbi.nlm.nih.gov/35134112
https://pubmed.ncbi.nlm.nih.gov/35134112
Autor:
David Bednar, Sucharita Dey, Emmanuel D. Levy, Natarajan Kannan, Bissan Al-Lazikani, Damiano Piovesan, Luis A Rodriguez, Sameer Velankar, Mihaly Varadi, Jan Stourac, Jaime Prilusky, Manjeet Kumar, Radoslav Krivak, Michael J.E. Sternberg, Juan Fernandez Recio, Daniel Zaidman, David R. Armstrong, Nathan J Rollins, Gulzar Singh, Jiri Damborsky, Dandan Xue, Stephen Anyango, Vivek Modi, Antonio Rosato, Christine A. Orengo, Valeria Putignano, Radka Svobodová, Alessia David, Debora S. Marks, Roland L. Dunbrack, Jose Ramon Macias, David Jakubec, Mark N. Wass, Luis Serrano, Silvio C. E. Tosatto, John M. Berrisford, Ahsan Tanweer, Sreenath Nair, Geoffrey J. Barton, Wim F. Vranken, Lukáš Pravda, Karel Berka, Stuart A McGowan, Janet M. Thornton, Nir London, Madhusudhan M Srivatsan, Lennart Martens, Atilio O Rausch, Toby J. Gibson, Pawel Rubach, Joanna I. Sulkowska, Petr Škoda, Gerardo Pepe, Nathalie Reuter, Natalia Tichshenko, Mandar Deshpande, Franca Fraternali, David Hoksza, Tom L. Blundell, R. Gonzalo Parra, Preeti Choudhary, José María Carazo, Claudia Andreini, Jake E McGreig, Leandro G Radusky, Thomas A. Hopf, Pathmanaban Ramasamy, Carlos Oscar S. Sorzano, Manuela Helmer-Citterich, Kelly P Brock, Nurul Nadzirin
Publikováno v:
Nucleic acids research
Nucleic Acids Research
Nucleic Acids Research (NAR)
D534-D542
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
D542
D534
Nucleic Acids Research
Nucleic Acids Research (NAR)
D534-D542
UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
D542
D534
The Protein Data Bank in Europe – Knowledge Base (PDBe-KB, https://pdbe-kb.org) is an open collaboration between world-leading specialist data resources contributing functional and biophysical annotations derived from or relevant to the Protein Dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050cb89e62952b78f542717c68240da1
https://kar.kent.ac.uk/95049/1/gkab988.pdf
https://kar.kent.ac.uk/95049/1/gkab988.pdf
Autor:
Marcia A. Hasenahuer, Alba Sanchis-Juan, Roman A. Laskowski, James A. Baker, James D. Stephenson, Christine A. Orengo, F. Lucy Raymond, Janet M. Thornton
Publikováno v:
Journal of Molecular Biology. 435:167892
Constrained Coding Regions (CCRs) in the human genome have been derived from DNA sequencing data of large cohorts of healthy control populations, available in the Genome Aggregation Database (gnomAD) [1]. They identify regions depleted of protein-cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683e74bca4d33876239710de22ffc1ee
https://doi.org/10.1016/j.jmb.2022.167892
https://doi.org/10.1016/j.jmb.2022.167892