Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Christine A. Graham"'
Autor:
Matthew C. Altman, Darawan Rinchai, Nicole Baldwin, Mohammed Toufiq, Elizabeth Whalen, Mathieu Garand, Basirudeen Syed Ahamed Kabeer, Mohamed Alfaki, Scott R. Presnell, Prasong Khaenam, Aaron Ayllón-Benítez, Fleur Mougin, Patricia Thébault, Laurent Chiche, Noemie Jourde-Chiche, J. Theodore Phillips, Goran Klintmalm, Anne O’Garra, Matthew Berry, Chloe Bloom, Robert J. Wilkinson, Christine M. Graham, Marc Lipman, Ganjana Lertmemongkolchai, Davide Bedognetti, Rodolphe Thiebaut, Farrah Kheradmand, Asuncion Mejias, Octavio Ramilo, Karolina Palucka, Virginia Pascual, Jacques Banchereau, Damien Chaussabel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
The blood transcriptome of human subjects can be profiled on an almost routine basis in translational research settings. Here the authors show that a fixed and well-characterized repertoire of transcriptional modules can be employed as a reusable fra
Externí odkaz:
https://doaj.org/article/53730b2675634242a15233e155dbf8a0
Autor:
Keith J. Price, Christine B. Graham, Bryn J. Witmier, Holly A. Chapman, Brooke L. Coder, Christian N. Boyer, Erik Foster, Sarah E. Maes, Ying Bai, Rebecca J. Eisen, Andrew D. Kyle
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 2, Pp 608-611 (2021)
We collected questing Haemaphysalis longicornis ticks from southeastern counties of Pennsylvania, USA. Of 263 ticks tested by PCR for pathogens, 1 adult female was positive for Borrelia burgdorferi sensu stricto, yielding a 0.4% infection rate. Conti
Externí odkaz:
https://doaj.org/article/12b9d92ae28d483e9387736ca9c163f3
Autor:
Elizabeth A. Dykstra, Hanna N. Oltean, David Kangiser, Nicola Marsden-Haug, Stephen M. Rich, Guang Xu, Min-Kuang Lee, Muhammad G. Morshed, Christine B. Graham, Rebecca J. Eisen
Publikováno v:
Emerging Infectious Diseases, Vol 26, Iss 4, Pp 648-657 (2020)
Tickborne diseases are rare in Washington, USA, and the ecology of these pathogens is poorly understood. We integrated surveillance data from humans and ticks to better describe their epidemiology and ecology. During 2011–2016, a total of 202 tickb
Externí odkaz:
https://doaj.org/article/bdc2cebc91824670ba0ea86e29b82a4b
Autor:
Akul Singhania, Christine M. Graham, Leona Gabryšová, Lúcia Moreira-Teixeira, Evangelos Stavropoulos, Jonathan M. Pitt, Probir Chakravarty, Annika Warnatsch, William J. Branchett, Laura Conejero, Jing-Wen Lin, Sophia Davidson, Mark S. Wilson, Gregory Bancroft, Jean Langhorne, Eva Frickel, Abdul K. Sesay, Simon L. Priestnall, Eleanor Herbert, Marianna Ioannou, Qian Wang, Ian R. Humphreys, Jonathan Dodd, Peter J. M. Openshaw, Katrin D. Mayer-Barber, Dragana Jankovic, Alan Sher, Clare M. Lloyd, Nicole Baldwin, Damien Chaussabel, Venizelos Papayannopoulos, Andreas Wack, Jacques F. Banchereau, Virginia M. Pascual, Anne O’Garra
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-21 (2019)
The authors present an extensive profile of host transcriptional respones to a diverse group of pathogens and allergens. In doing so, they identify TH1, type I IFN, TH17, and TH2 responses, that underlie each immune response in both the blood and lun
Externí odkaz:
https://doaj.org/article/2de9148c41624ebdb261719be7a52d90
Autor:
Akul Singhania, Raman Verma, Christine M. Graham, Jo Lee, Trang Tran, Matthew Richardson, Patrick Lecine, Philippe Leissner, Matthew P. R. Berry, Robert J. Wilkinson, Karine Kaiser, Marc Rodrigue, Gerrit Woltmann, Pranabashis Haldar, Anne O’Garra
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Mass screening diagnostics for Mycobacterium tuberculosis exist, but criticisms exist regarding the sensitivity and specificity of these tools. Here the authors use RNA-Seq and a modular bioinformatics approach using data from their own cohorts and m
Externí odkaz:
https://doaj.org/article/f00dac82845249b8a6fa26d64cff3275
Publikováno v:
Journal of Medical Entomology. 58:1219-1233
Lyme disease is the most common vector-borne disease in the United States. While Lyme disease vectors are widespread, high incidence states are concentrated in the Northeast, North Central and Mid-Atlantic regions. Mapping the distribution of Lyme di
Autor:
James L. McManaman, Elise S. Bales, David J. Orlicky, Matthew Jackman, Paul S. MacLean, Shannon Cain, Amanda E. Crunk, Ayla Mansur, Christine E. Graham, Thomas A. Bowman, Andrew S. Greenberg
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 5, Pp 1346-1359 (2013)
The cytoplasmic lipid droplet (CLD) protein perilipin-2 (Plin2) is expressed in multiple nonadipose tissues, where it is thought to play a role in regulating their lipid storage properties. However, the extent to which Plin2 functions in nutrient uti
Externí odkaz:
https://doaj.org/article/4f340467484b405ea7c8616f0a966032
Autor:
Jonathan M Pitt, Simon Blankley, Krzysztof Potempa, Christine M Graham, Lucia Moreira-Teixeira, Finlay W McNab, Ashleigh Howes, Evangelos Stavropoulos, Virginia Pascual, Jacques Banchereau, Damien Chaussabel, Anne O'Garra
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0150251 (2016)
Analysis of the mouse transcriptional response to Listeria monocytogenes infection reveals that a large set of genes are perturbed in both blood and tissue and that these transcriptional responses are enriched for pathways of the immune response. Fur
Externí odkaz:
https://doaj.org/article/dba7016d7b4e4e13a7410c44c6df3b2e
Autor:
Simon Blankley, Christine M Graham, Jacob Turner, Matthew P R Berry, Chloe I Bloom, Zhaohui Xu, Virginia Pascual, Jacques Banchereau, Damien Chaussabel, Ronan Breen, George Santis, Derek M Blankenship, Marc Lipman, Anne O'Garra
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0162220 (2016)
Mycobacterium tuberculosis infection is a leading cause of infectious death worldwide. Gene-expression microarray studies profiling the blood transcriptional response of tuberculosis (TB) patients have been undertaken in order to better understand th
Externí odkaz:
https://doaj.org/article/492ef460bc454e32bb95b445142c6ee5
Autor:
Olivier Tabone, Kaori L. Fonseca, Christine M. Graham, Baltazar Cá, Evangelos Stavropoulos, Margarida Saraiva, Akul Singhania, Pranabashis Haldar, Katrin D. Mayer-Barber, Simon L. Priestnall, Probir Chakravarty, Raman Verma, Anne O'Garra, Paul S. Redford, Lúcia Moreira-Teixeira, Jeremy Sousa, Eleanor Herbert, Alan Sher, Alejandro Suárez-Bonnet
Publikováno v:
Nature immunology
Although mouse infection models have been extensively used to study the host response to Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis (TB) resistance and disease progression has been heavily debated. Here