Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Christine A. Doucette"'
Autor:
Maria F. Fernandes, Juan J. Aristizabal-Henao, Phillip M. Marvyn, Iman M'Hiri, Meghan A. Wiens, Monica Hoang, Manuel Sebastian, Renato Nachbar, Philippe St-Pierre, Kalsha Diaguarachchige De Silva, Geoffrey A. Wood, Jamie W. Joseph, Christine A. Doucette, André Marette, Ken D. Stark, Robin E. Duncan
Publikováno v:
Molecular Metabolism, Vol 81, Iss , Pp 101887- (2024)
Objective: Lipotoxic injury from renal lipid accumulation in obesity and type 2 diabetes (T2D) is implicated in associated kidney damage. However, models examining effects of renal ectopic lipid accumulation independent of obesity or T2D are lacking.
Externí odkaz:
https://doaj.org/article/8c9b9df421da488caebe865e8aca19a9
Autor:
Matthew D. Martens, Nivedita Seshadri, Lucas Nguyen, Donald Chapman, Elizabeth S. Henson, Bo Xiang, Landon Falk, Arielys Mendoza, Sunil Rattan, Jared T. Field, Philip Kawalec, Spencer B. Gibson, Richard Keijzer, Ayesha Saleem, Grant M. Hatch, Christine A. Doucette, Jason M. Karch, Vernon W. Dolinsky, Ian M. Dixon, Adrian R. West, Christof Rampitsch, Joseph W. Gordon
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-16 (2021)
Abstract Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent role in the evolution of necrotic cell death, disrupting ER calcium homeostasis and i
Externí odkaz:
https://doaj.org/article/e1343dcb2c5b484c91d04a2bde3e5a8e
Autor:
Nivedita Seshadri, Michael E. Jonasson, Kristin L. Hunt, Bo Xiang, Steven Cooper, Michael B. Wheeler, Vernon W. Dolinsky, Christine A. Doucette
Publikováno v:
Molecular Metabolism, Vol 6, Iss 7, Pp 760-769 (2017)
Objective: Upregulation of uncoupling protein 2 (UCP2) is associated with impaired glucose-stimulated insulin secretion (GSIS), which is thought to be an important contributor to pathological β cell failure in obesity and type 2 diabetes (T2D); howe
Externí odkaz:
https://doaj.org/article/067a1dd4561e4b33a69874c8cbc783c1
Autor:
Brittany L. Moyce Gruber, Laura K. Cole, Bo Xiang, Mario A. Fonseca, Julianne Klein, Grant M. Hatch, Christine A. Doucette, Vernon W. Dolinsky
Publikováno v:
Diabetologia. 65:733-747
Autor:
Hesham Shamshoum, Hana A. Dibe, Jibran Y. Khokhar, Greg L. McKie, David C. Wright, Hayley H. A. Thorpe, Christine A. Doucette, Kristin Hunt
Publikováno v:
The Journal of Physiology. 600:829-845
Key points Ambient cold exposure is often regarded as a promising anti-obesity treatment in mice. However, most preclinical studies aimed at treating obesity via cold-induced thermogenesis have been confounded by sub-thermoneutral housing temperature
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 322(5)
The pancreatic islet is responsive to an array of endocrine, paracrine, and nutritional inputs that adjust hormone secretion to ensure accurate control of glucose homeostasis. Although the mechanisms governing glucose-coupled insulin secretion have r
Autor:
Brittany L, Moyce Gruber, Laura K, Cole, Bo, Xiang, Mario A, Fonseca, Julianne, Klein, Grant M, Hatch, Christine A, Doucette, Vernon W, Dolinsky
Publikováno v:
Diabetologia. 65(4)
Obesity and hepatic steatosis are risk factors for gestational diabetes mellitus (GDM), a common complication of pregnancy. Adiponectin is a fat-derived hormone that improves hepatic steatosis and insulin sensitivity. Low levels of circulating adipon
Autor:
Marilyne Vandel, Christine A. Doucette, Mario Fonseca, Genevieve C. Sparagna, Grant M. Hatch, Nivedita Seshadri, Bo Xiang, Prasoon Agarwal, Vernon W. Dolinsky, Laura K. Cole
Publikováno v:
Endocrinology
Tafazzin (TAZ) is a cardiolipin (CL) biosynthetic enzyme important for maintaining mitochondrial function. TAZ affects both the species and content of CL in the inner mitochondrial membrane, which are essential for normal cellular respiration. In pan
Autor:
Grant M. Hatch, Mario Fonseca, Bo Xiang, Laura K. Cole, Troy J. Pereira, Navdeep Brar, Gabriel Brawerman, Stephanie M. Kereliuk, Vernon W. Dolinsky, Kristin Hunt, Christine A. Doucette, Nivedita Seshadri
Publikováno v:
The Journal of Physiology. 597:4175-4192
Key points Maternal resveratrol (RESV) administration in gestational diabetes (GDM) restored normoglycaemia and insulin secretion. GDM-induced obesity was prevented in male GDM+RESV offspring but not in females. GDM+RESV offspring exhibited improved
Autor:
Mario Fonseca, Prasoon Agarwal, Christine A. Doucette, Bo Xiang, Vernon W. Dolinsky, Grant M. Hatch, Stephanie M. Kereliuk, Kristin Hunt, Taylor Morriseau, Nivedita Seshadri, Navdeep Brar, Aruni Jha, Laura K. Cole
Publikováno v:
Endocrinology
Fetal exposure to gestational diabetes mellitus (GDM) and poor postnatal diet are strong risk factors for type 2 diabetes development later in life, but the mechanisms connecting GDM exposure to offspring metabolic health remains unclear. In this stu