Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christine A. Biondi"'
Autor:
Caroline S. Hill, Michael Howell, Christine A. Biondi, Elizabeth K. Bikoff, Ayesha Islam, Elizabeth J. Robertson, Debipriya Das
Smad4 in partnership with R-Smads (receptor-regulated Smads) activates TGF-β (transforming growth factor-β)-dependent signalling pathways essential for early mouse development. Smad4 null embryos die shortly after implantation due to severe defects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8b60f6a98fefd507fb972a64f46148b
https://ora.ox.ac.uk/objects/uuid:6b64aa87-2ab3-4287-b583-b0c011382f56
https://ora.ox.ac.uk/objects/uuid:6b64aa87-2ab3-4287-b583-b0c011382f56
Autor:
Michael Gartside, Nicholas K. Hayward, Magdalena M. Serewko-Auret, Kelly A. Loffler, Graham F. Kay, Russell Duncan, Christine A. Biondi, Arne W. Mould
Publikováno v:
International Journal of Cancer. 124:1122-1132
Heterozygous disruption of the Men1 gene predisposes mice to the development of multiple endocrine tumors, accurately mimicking the human MEN1 cancer predisposition syndrome. Additionally, Men1(+/-) mice frequently develop sex cord adenomas. The mech
Autor:
Magdalena M. Serewko-Auret, Russell Duncan, Graham F. Kay, Nicholas K. Hayward, Kelly A. Loffler, Arne W. Mould, Michael Gartside, Christine A. Biondi
Publikováno v:
International Journal of Cancer. 121:776-783
Although the identification of menin-interacting partners and other evidence support a role for menin, the multiple endocrine neoplasia type 1 gene (MEN1) product, in regulating gene expression, little is known about the cellular pathways dysregulate
Autor:
Orit Rozenblatt-Rosen, Arindam Bhattacharjee, Kalai Selvi Shanmugam, Stuart S. Levine, Graham F. Kay, D. Neil Hayes, Jeffrey C. Lee, Terry D. Copeland, Christina M. Hughes, Christine A. Biondi, Thomas A. Milne, Nicholas K. Hayward, Jay L. Hess, Matthew Meyerson
Publikováno v:
Molecular Cell. 13(4):587-597
The cellular function of the menin tumor suppressor protein, product of the MEN1 gene mutated in familial multiple endocrine neoplasia type 1, has not been defined. We now show that menin is associated with a histone methyltransferase complex contain
Autor:
Zhi Liu, Jenny Fung Ling Chau, Christine A Biondi, Bi Jin Au, Lin He, Keng Po Lai, Zhongfeng Wang, Xin Zhang, Yuji Mishina, Dong Xie, Elizabeth J. Robertson, Wai Fook Leong, Yuanyu Hu, Ye-Guang Chen, Xueying Wang, Hao Jia, Huijuan Liu, Deyong Jia, Qiang Yu, Baojie Li
Publikováno v:
Nature communications. 3
DNA damage and the elicited cellular response underlie the etiology of tumorigenesis and ageing. Yet, how this response integrates inputs from cells' environmental cues remains underexplored. Here we report that the BMP-Smad1 pathway, which is essent
Autor:
Elizabeth J. Robertson, Jennifer M. Taylor, Elizabeth K. Bikoff, Ita Costello, Christine A Biondi
Publikováno v:
BMC Developmental Biology
BMC Developmental Biology, Vol 9, Iss 1, p 54 (2009)
BMC Developmental Biology, Vol 9, Iss 1, p 54 (2009)
BackgroundSmad4 mutant embryos arrest shortly after implantation and display a characteristic shortened proximodistal axis, a significantly reduced epiblast, as well as a thickened visceral endoderm layer. Conditional rescue experiments demonstrate t
Autor:
Michael Gartside, Nicholas K. Hayward, Kelly A. Loffler, Christine A. Biondi, Magdalena M. Serewko-Auret, Russell Duncan, HK Muller, Arne W. Mould, Graham F. Kay, Paul Waring, Ian D. Tonks
Publikováno v:
Oncogene. 26(27)
To identify possible genetic interactions between the mechanisms of tumor suppression of menin and pRb, we intercrossed mice with targeted deletions of Men1 and Rb1, and compared tumor development in cohorts of animals carrying single or dual mutatio
Autor:
H. Konrad Muller, Kelly A. Loffler, Magdalena M. Serewko-Auret, Paul Waring, Nicholas K. Hayward, Graham F. Kay, Michael Gartside, Mitchell S. Stark, Christine A. Biondi
Publikováno v:
International journal of cancer. 120(2)
Multiple endocrine neoplasia type 1 (MEN1) is an inherited cancer predisposition syndrome typified by development of tumors in parathyroid, pituitary and endocrine pancreas, as well as less common sites including both endocrine and nonendocrine organ
Autor:
Kelly A. Loffler, Graham F. Kay, Paul Waring, Nicholas K. Hayward, Christine A. Biondi, Mitchell S. Stark, Michael Gartside, Mark A. Magnuson
Mutations of the MEN1 gene, encoding the tumor suppressor menin, predispose individuals to the cancer syndrome multiple endocrine neoplasia type 1, characterized by the development of tumors of the endocrine pancreas and anterior pituitary and parath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c47c3a0e1a3d77b22218de00424d052
https://europepmc.org/articles/PMC381682/
https://europepmc.org/articles/PMC381682/
Autor:
Ian D. Tonks, Graham F. Kay, Christine A. Biondi, Michael Gartside, Nicholas K. Hayward, Carol Paterson
Publikováno v:
Genesis (New York, N.Y. : 2000). 32(2)