Semliki Forest Virus Expressing Interleukin-12 Induces Antiviral and Antitumoral Responses in Woodchucks with Chronic Viral Hepatitis and Hepatocellular Carcinoma

Autor: Scott D. Butler, Stephan Menne, Christine A. Bellezza, Katherine H. Liu, Nathan L. Dykes, Marta Ruiz-Guillen, Gloria González-Aseguinolaza, Bud C. Tennant, Jesús Prieto, Juan R. Rodriguez-Madoz, Jose I. Quetglas, Julien Crettaz, Cristian Smerdou, Itziar Otano

Publikováno v: Journal of Virology. 83:12266-12278

A vector based on Semliki Forest virus (SFV) expressing high levels of interleukin-12 (SFV-enhIL-12) has previously demonstrated potent antitumoral efficacy in small rodents with hepatocellular carcinoma (HCC) induced by transplantation of tumor cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc71f3a98d2c48be4c900a868c11cca
https://doi.org/10.1128/jvi.01597-09

List of Contributors

Autor: Christian R. Abee, Walter Akers, Lynn C. Anderson, Keith M. Astrofsky, Janet Baer, David G. Baker, Henry J. Baker, Betty H. Baldwin, Stephen W. Barthold, Nicole Baumgarth, Kathryn A.L. Bayne, Bonnie V. Beaver, Christine A. Bellezza, B. Taylor Bennett, Ingrid Bergin, Ruth Blauwiekel, David W. Brammer, Marilyn J. Brown, Tanya Burkholder, Calvin B. Carpenter, Maia M. Chan, Kimberly Cheng, Thomas B. Clarkson, Charles B. Clifford, J. Mark Cline, Lesley A. Colby, Patrick W. Concannon, Lisa A. Conti, Leslie I. Curtin, Margaret L. Delano, Thomas M. Donnelly, Raimon Duran-Struuck, Robert C. Dysko, Melissa C. Dyson, Michael Y. Esmail, Paula C. Ezell, Michale S. Fee, Carmen Ledesma Feliciano, Paul Flecknell, James G. Fox, Craig L. Franklin, Alexis Garcia, Rose Gillesby, Lou Ann Graham, F. Claire Hankenson, John E. Harkness, Kristi L. Helke, Hilda Holcombe, William E. Hornbuckle, Charlie C. Hsu, Melanie Ihrig, Carlisle P. Landel, Rusty Lansford, Christian Lawrence, Steven L. Leary, Rafael Y. Lefkowitz, Kvin Lertpiriyapong, Patrick A. Lester, Neil S. Lipman, Jennifer L.S. Lofgren, Elizabeth R. Magden, Rachel D. Malcolm, Keith G. Mansfield, Robert P. Marini, Kirk J. Maurer, Joerg Mayer, Joy A. Mench, Marian G. Michaels, Emily L. Miedel, Scott A. Mischler, Daniel D. Myers, Jean A. Nemzek, Steven M. Niemi, Megan H. Nowland, Dorcas P. O’Rourke, Glen M. Otto, Mary M. Patterson, Kathleen R. Pritchett-Corning, Fred W. Quimby, Peter M. Rabinowitz, Richard J. Rahija, Carrie A. Redlich, Laura G. Reinholdt, Matthew D. Rosenbaum, Lois Roth, Howard G. Rush, Trenton R. Schoeb, Adam Schoell, Fabrizio C. Serluca, Sandra Sexton, William R. Shek, Nirah H. Shomer, Joe H. Simmons, Abigail L. Smith, Michael K. Stoskopf, Marjorie C. Strobel, James R. Swearengen, M. Michael Swindle, Michael R. Talcott, Bud C. Tennant, Wendy J. Underwood, Sue VandeWoude, Benjamin J. Weigler, Mark T. Whary, Colette L. Wheler, Ronald P. Wilson, Christina Winnicker, A. Marissa Wolfe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1f58a00338eaf1e0d79026aadf432648
https://doi.org/10.1016/b978-0-12-409527-4.00047-x

Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

Autor: Grushenka H.I. Wolfgang, Dalal AlDeghaither, Peng Yue, Christine A. Bellezza, Li Li, Randall L. Halcomb, Stephane Daffis, Jim Zheng, Abigail Fosdick, Katherine H. Liu, Linta M. Thampi, Bud C. Tennant, Baldwin Bh, Daniel B. Tumas, Stephan Menne, Paul J. Cote, Simon P. Fletcher

Publikováno v: Journal of hepatology. 62(6)

Background & Aims New therapies for chronic hepatitis B (CHB) are urgently needed since current treatments rarely lead to cure. We evaluated whether the oral small molecule toll-like receptor (TLR7) agonist GS-9620 could induce durable antiviral effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21cdda822feb1328b9890b9685f9383
https://pubmed.ncbi.nlm.nih.gov/25559326

Electroporation enhances immunogenicity of a DNA vaccine expressing woodchuck hepatitis virus surface antigen in woodchucks

Autor: Stephan Menne, Katherine H. Liu, Paul J. Cote, Christine A. Bellezza, Bud C. Tennant, Abraham J. Bezuidenhout, Drew Hannaman, Mary Ascenzi, Alain Luxembourg, Claire F. Evans, Gloria González-Aseguinolaza

Publikováno v: Journal of virology. 85(10)

The development of therapeutic vaccines for chronic hepatitis B virus (HBV) infection has been hampered by host immune tolerance and the generally low magnitude and inconsistent immune responses to conventional vaccines and proposed new delivery meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c9d61a463908bb682a3c76cd23d575
https://pubmed.ncbi.nlm.nih.gov/21389124

List of Contributors

Autor: Christian R. Abee, Robert J. Adams, Lynn C. Anderson, Keith M. Astrofsky, Henry J. Baker, Kathryn A.L. Bayne, Bonnie V. Beaver, Christine A. Bellezza, Bruce J. Bernacky, Sarah A. Bingel, David W. Brammer, Robert A. Bullis, Clarence E. Chrisp, Charles B. Clifford, Bennett J. Cohen, Patrick W. Concannon, Muriel Davisson, Margaret L. Delano, George J. DeMarco, Thomas M. Donnelly, Robert C. Dysko, Susan Erdman, James G. Fox, Linda K. Fulton, Diane J. Gaertner, James G. Geistfeld, Susan V. Gibson, James A. Goodrich, Brenda Griffin, Thomas E. Hamm, F. Claire Hankenson, John E. Harkness, Jack R. Hessler, William E. Hornbuckle, Robert O. Jacoby, Michale E. Keeling, Dennis F. Kohn, Kathy E. Laber, Steven L. Leary, Stephen I. Levin, J. Russell Lindsey, Neil S. Lipman, Franklin M. Loew, Robert P. Marini, Joy A. Mench, Marian G. Michaels, Scott A. Mischler, Maria R. Moalli, Glenn M. Monastersky, David B. Morton, Kathleen A. Murray, Jean A. Nemzek, Christian E. Newcomer, Dorcas P. O'Rourke, Glen Otto, Lori Palley, Scott E. Perkins, Sulli Popilskis, Fred W. Quimby, Lois Roth, Harry Rozmiarek, Howard G. Rush, Charles G. Sagerström, Evelyn E. Sargent, Terry Wayne Schultz, Juergen Schumacher, Peter A. Schweitzer, John J. Sharp, William R. Shek, Alison C. Smith, Michael K. Stoskopf, Mark A. Suckow, M. Michael Swindle, Bud C. Tennant, Wendy J. Underwood, Gerald L. Van Hoosier, George A. Vogler, Joseph E. Wagner, Mark T. Whary

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76aaf5bd61ab3d8ca5cf9bef79b084aa
https://doi.org/10.1016/b978-012263951-7/50001-6