Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Christine A, Seers"'
Autor:
Abu Sayeed M. Mahmud, Christine A. Seers, N. Laila Huq, Lianyi Zhang, Catherine A. Butler, Caroline Moore, Keith J. Cross, Eric C. Reynolds
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The Arg-specific gingipains of Porphyromonas gingivalis RgpA and RgpB have 97% identical sequences in their catalytic domains yet their propeptides are only 76% identical. RgpA isolates as a proteinase–adhesin complex (HRgpA) which hinders
Externí odkaz:
https://doaj.org/article/62373cb149f64e4582bd5da8e3e92f8e
Autor:
A. Sayeed. M. Mahmud, Christine A. Seers, Aftab Ali Shaikh, Tarannum Taznin, Mohammad Samir Uzzaman, Eshrar Osman, Md. Ahashan Habib, Shahina Akter, Tanjina Akhtar Banu, Md. Murshed Hasan Sarkar, Barna Goswami, Iffat Jahan, Chioma M. Okeoma, Md. Salim Khan, Eric C. Reynolds
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract The impact of SARS-CoV-2 infection on the nasopharyngeal microbiome has not been well characterised. We sequenced genetic material extracted from nasopharyngeal swabs of SARS-CoV-2-positive individuals who were asymptomatic (n = 14), had mil
Externí odkaz:
https://doaj.org/article/4da02de0a779453ab8da8a90ae52f6c5
Publikováno v:
Journal of Oral Microbiology, Vol 13, Iss 1 (2021)
Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors of P. gingivalis, a keystone pathogen in the development of destructive periodontal disease. The gingipains function as
Externí odkaz:
https://doaj.org/article/bca681ae1ef24739a5c036c87de9cb02
Autor:
Jacqueline E Heath, Christine A Seers, Paul D Veith, Catherine A Butler, Nor A Nor Muhammad, Yu-Yen Chen, Nada Slakeski, Benjamin Peng, Lianyi Zhang, Stuart G Dashper, Keith J Cross, Steven M Cleal, Caroline Moore, Eric C Reynolds
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164313 (2016)
Porphyromonas gingivalis utilises the Bacteroidetes-specific type IX secretion system (T9SS) to export proteins across the outer membrane (OM), including virulence factors such as the gingipains. The secreted proteins have a conserved carboxy-termina
Externí odkaz:
https://doaj.org/article/6ee27ae2f9cc4f86a398e9fbf01f3198
Autor:
Lianyi Zhang, Catherine A Butler, Hasnah S G Khan, Stuart G Dashper, Christine A Seers, Paul D Veith, Jian-Guo Zhang, Eric C Reynolds
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0151407 (2016)
PgMntR is a predicted member of the DtxR family of transcriptional repressors responsive to manganese in the anaerobic periodontal pathogen Porphyromonas gingivalis. Our bioinformatic analyses predicted that PgMntR had divalent metal binding site(s)
Externí odkaz:
https://doaj.org/article/d4a75a7fc64544439c9091bc95393c35
Autor:
Dhana G Gorasia, Paul D Veith, Dina Chen, Christine A Seers, Helen A Mitchell, Yu-Yen Chen, Michelle D Glew, Stuart G Dashper, Eric C Reynolds
Publikováno v:
PLoS Pathogens, Vol 11, Iss 9, p e1005152 (2015)
The type IX secretion system (T9SS) of Porphyromonas gingivalis secretes proteins possessing a conserved C-terminal domain (CTD) to the cell surface. The C-terminal signal is essential for these proteins to translocate across the outer membrane via t
Externí odkaz:
https://doaj.org/article/e11022a894ac41ff8b57dec5a25d50f4
Publikováno v:
Journal of Oral Pathology & Medicine. 48:604-610
Background Green tea is heavily consumed on a global basis for its health benefits. The active ingredient, (-)-epigallocatechin gallate (EGCG), is a major polyphenol demonstrated to inhibit the growth of various non-oral cancer cell lines and interfe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc6701c77f8c35e09528fc765c4206f
https://doi.org/10.1111/jop.12914
https://doi.org/10.1111/jop.12914
Autor:
Kheng H Tan, Christine A Seers, Stuart G Dashper, Helen L Mitchell, James S Pyke, Vincent Meuric, Nada Slakeski, Steven M Cleal, Jenny L Chambers, Malcolm J McConville, Eric C Reynolds
Publikováno v:
PLoS Pathogens, Vol 10, Iss 3, p e1003955 (2014)
Porphyromonas gingivalis and Treponema denticola are strongly associated with chronic periodontitis. These bacteria have been co-localized in subgingival plaque and demonstrated to exhibit symbiosis in growth in vitro and synergistic virulence upon c
Externí odkaz:
https://doaj.org/article/9b45a54bde574be896440d0d9b95ffc2
Autor:
Dhana G. Gorasia, Christine A. Seers, Jacqueline E. Heath, Michelle D. Glew, Hamid Soleimaninejad, Catherine A. Butler, Mark J. McBride, Paul D. Veith, Eric C. Reynolds
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 10; Pages: 5681
The Bacteroidetes type IX secretion system (T9SS) consists of at least 20 components that translocate proteins with type A or type B C-terminal domain (CTD) signals across the outer membrane (OM). While type A CTD proteins are anchored to the cell su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26f1596a75ea857dcb86ebff11cb380
https://doi.org/10.3390/ijms23105681
https://doi.org/10.3390/ijms23105681
Autor:
Catherine A Butler, Stuart G Dashper, Lianyi Zhang, Christine A Seers, Helen L Mitchell, Deanne V Catmull, Michelle D Glew, Jacqueline E Heath, Yan Tan, Hasnah S G Khan, Eric C Reynolds
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111168 (2014)
Porphyromonas gingivalis is a Gram-negative pathogen associated with the biofilm-mediated disease chronic periodontitis. P. gingivalis biofilm formation is dependent on environmental heme for which P. gingivalis has an obligate requirement as it is u
Externí odkaz:
https://doaj.org/article/207999d84c3f40249b4bb2859962b8f5