Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Christine, Vande Velde"'
Autor:
Florian Pernin, Qiao-Ling Cui, Abdulshakour Mohammadnia, Milton G. F. Fernandes, Jeffery A. Hall, Myriam Srour, Roy W. R. Dudley, Stephanie E. J. Zandee, Wendy Klement, Alexandre Prat, Hannah E. Salapa, Michael C. Levin, G. R. Wayne Moore, Timothy E. Kennedy, Christine Vande Velde, Jack P. Antel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Oligodendrocyte (OL) injury and subsequent loss is a pathologic hallmark of multiple sclerosis (MS). Stress granules (SGs) are membrane-less organelles containing mRNAs stalled in translation and considered as participants of the cellular re
Externí odkaz:
https://doaj.org/article/7ecd4f332096485d86164c4aeb9e24fc
Autor:
Myriam Gagné, Jade-Emmanuelle Deshaies, Hadjara Sidibé, Yousri Benchaar, Danielle Arbour, Alicia Dubinski, Gurleen Litt, Sarah Peyrard, Richard Robitaille, Chantelle F. Sephton, Christine Vande Velde
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
RNA binding proteins (RBPs) play a key role in cellular growth, homoeostasis and survival and are tightly regulated. A deep understanding of their spatiotemporal regulation is needed to understand their contribution to physiology and pathology. Here,
Externí odkaz:
https://doaj.org/article/2457c80e01774b2b8bc6697879d5b7c2
Autor:
Hana Fakim, Christine Vande Velde
Publikováno v:
Seminars in Cell & Developmental Biology.
Autor:
Marius Chiasseu, Luis Alarcon-Martinez, Nicolas Belforte, Heberto Quintero, Florence Dotigny, Laurie Destroismaisons, Christine Vande Velde, Fany Panayi, Caroline Louis, Adriana Di Polo
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-20 (2017)
Abstract Background Tau is an axon-enriched protein that binds to and stabilizes microtubules, and hence plays a crucial role in neuronal function. In Alzheimer’s disease (AD), pathological tau accumulation correlates with cognitive decline. Substa
Externí odkaz:
https://doaj.org/article/ba4cd4b957d247038e5bb2d2f25f57cd
Publikováno v:
eLife, Vol 7 (2018)
Despite being an early event in ALS, it remains unclear whether the denervation of neuromuscular junctions (NMJ) is simply the first manifestation of a globally degenerating motor neuron. Using in vivo imaging of single axons and their NMJs over a th
Externí odkaz:
https://doaj.org/article/b640df4b78574d8dbeabb9159560b3b4
Autor:
Eric Bareke, Ze'ev Melamed, Laurie Destroimaisons, Lorne Zinman, Geneviève Di Tomasso, Elizabeth M. H. Tank, Martine Tétreault, Pascale Legault, Anaïs Aulas, Jade-Emmanuelle Deshaies, Sami J. Barmada, Shangxi Xiao, J. Alex Parker, Janice Robertson, Hana Fakim, Christine Vande Velde, Hadjara Sidibé, Paul M. McKeever, Nicolás B. Gómez, Yousra Khalfallah
Publikováno v:
Brain
TDP-43 nuclear depletion and concurrent cytoplasmic accumulation in vulnerable neurons is a hallmark feature of progressive neurodegenerative proteinopathies such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cellular stre
Autor:
Alicia Dubinski, Myriam Gagné, Sarah Peyrard, David Gordon, Kevin Talbot, Christine Vande Velde
Publikováno v:
Human molecular genetics.
Responding effectively to external stress is crucial for neurons. Defective stress granule dynamics has been hypothesized as one of the pathways that renders motor neurons in amyotrophic lateral sclerosis (ALS) more prone to early death. Specifically
Publikováno v:
Journal of Neurochemistry
Ras‐GTPase‐activating protein (GAP)‐binding protein 1 (G3BP1) is a multi‐functional protein that is best known for its role in the assembly and dynamics of stress granules. Recent studies have highlighted that G3BP1 also has other functions r
Autor:
Vincent Picher-Martel, Claire Magnussen, Mathieu Blais, Tania Bubela, Samir Das, Annie Dionne, Alan C. Evans, Angela Genge, Russell Greiner, Yasser Iturria-Medina, Wendy Johnston, Kelvin Jones, Hannah Kaneb, Jason Karamchandani, Sara Moradipoor, Janice Robertson, Ekaterina Rogaeva, David M. Taylor, Christine Vande Velde, Yana Yunusova, Lorne Zinman, Sanjay Kalra, Nicolas Dupré
Publikováno v:
Amyotrophic lateral sclerosisfrontotemporal degeneration.
The absence of disease modifying treatments for amyotrophic lateral sclerosis (ALS) is in large part a consequence of its complexity and heterogeneity. Deep clinical and biological phenotyping of people living with ALS would assist in the development
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2428
Stress granules have gained considerable exposure and interest in recent years. These micron-sized entities, composed of RNA and protein, form following a stress exposure and have been linked to several pathologies. Understanding stress granule funct