Zobrazeno 1 - 10
of 206
pro vyhledávání: '"Christine, Sers"'
Autor:
Paul Jank, Jonas Leichsenring, Svenja Kolb, Inga Hoffmann, Philip Bischoff, Catarina Alisa Kunze, Mihnea P. Dragomir, Moritz Gleitsmann, Moritz Jesinghaus, Wolfgang D. Schmitt, Hagen Kulbe, Christine Sers, Albrecht Stenzinger, Jalid Sehouli, Ioana Elena Braicu, Christina Westhoff, David Horst, Carsten Denkert, Stefan Gröschel, Eliane T. Taube
Publikováno v:
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-13 (2023)
Abstract Background Mechanisms of development and progression of high-grade serous ovarian cancer (HGSOC) are poorly understood. EVI1 and PARP1, part of TGF-ß pathway, are upregulated in cancers with DNA repair deficiencies with DNA repair deficienc
Externí odkaz:
https://doaj.org/article/6475539f264d451aaaf6ee746f0741b3
Autor:
Inga Hoffmann, Mihnea P. Dragomir, Nanna Monjé, Carlotta Keunecke, Catarina Alisa Kunze, Simon Schallenberg, Sofya Marchenko, Wolfgang D. Schmitt, Hagen Kulbe, Jalid Sehouli, Ioana Elena Braicu, Paul Jank, Carsten Denkert, Silvia Darb-Esfahani, David Horst, Bruno V. Sinn, Christine Sers, Philip Bischoff, Eliane T. Taube
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 44, Iss , Pp 100934- (2023)
Background: The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays a crucial role in regulating the immune system's response to tumors, but its exact role in cancer, especially in high-grade serous ovarian cancer (HGSOC), remains controversial. We aim
Externí odkaz:
https://doaj.org/article/b6f31ec2a1e44774a733c2bd83866df5
Autor:
Mihnea P. Dragomir, Teodor G. Calina, Eilís Perez, Simon Schallenberg, Meng Chen, Thomas Albrecht, Ines Koch, Peggy Wolkenstein, Benjamin Goeppert, Stephanie Roessler, George A. Calin, Christine Sers, David Horst, Florian Roßner, David Capper
Publikováno v:
EBioMedicine, Vol 93, Iss , Pp 104657- (2023)
Summary: Background: Differentiating intrahepatic cholangiocarcinomas (iCCA) from hepatic metastases of pancreatic ductal adenocarcinoma (PAAD) is challenging. Both tumours have similar morphological and immunohistochemical pattern and share multiple
Externí odkaz:
https://doaj.org/article/db8391b0915642daa4b44af43c287256
Autor:
Luc Pilotte, Benoit J Van den Eynde, Jingjing Zhu, Christine Sers, Marie Solvay, Pauline Holfelder, Simon Klaessens, Vincent Stroobant, Juliette Lamy, Stefan Naulaerts, Quentin Spillier, Raphaël Frédérick, Etienne De Plaen, Christiane A Opitz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan-dioxygenase (TDO) are enzymes catabolizing the essential amino acid tryptophan into kynurenine. Expression of these enzymes is frequently observed in advanced-stage cancers and is associa
Externí odkaz:
https://doaj.org/article/8b5d6705c624408ca6c9425808c1b3f5
Autor:
Tincy Simon, Pamela Riemer, Armin Jarosch, Katharina Detjen, Annunziata Di Domenico, Felix Bormann, Andrea Menne, Slim Khouja, Nanna Monjé, Liam H. Childs, Dido Lenze, Ulf Leser, Florian Rossner, Markus Morkel, Nils Blüthgen, Marianne Pavel, David Horst, David Capper, Ilaria Marinoni, Aurel Perren, Soulafa Mamlouk, Christine Sers
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-14 (2022)
Abstract Background Pancreatic neuroendocrine neoplasms (PanNENs) fall into two subclasses: the well-differentiated, low- to high-grade pancreatic neuroendocrine tumors (PanNETs), and the poorly-differentiated, high-grade pancreatic neuroendocrine ca
Externí odkaz:
https://doaj.org/article/2f176528de284862b6e90f388629cecf
Autor:
Florian Uhlitz, Philip Bischoff, Stefan Peidli, Anja Sieber, Alexandra Trinks, Mareen Lüthen, Benedikt Obermayer, Eric Blanc, Yana Ruchiy, Thomas Sell, Soulafa Mamlouk, Roberto Arsie, Tzu‐Ting Wei, Kathleen Klotz‐Noack, Roland F Schwarz, Birgit Sawitzki, Carsten Kamphues, Dieter Beule, Markus Landthaler, Christine Sers, David Horst, Nils Blüthgen, Markus Morkel
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 10, Pp 1-17 (2021)
Abstract In colorectal cancer, oncogenic mutations transform a hierarchically organized and homeostatic epithelium into invasive cancer tissue lacking visible organization. We sought to define transcriptional states of colorectal cancer cells and sig
Externí odkaz:
https://doaj.org/article/cc6f299b784d44ffb0f05c6f27ba79b1
Autor:
Maria Rivera, Iduna Fichtner, Annika Wulf-Goldenberg, Christine Sers, Johannes Merk, Giannino Patone, Keziban M. Alp, Tamara Kanashova, Philipp Mertins, Jens Hoffmann, Ulrike Stein, Wolfgang Walther
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 21-35 (2021)
Patient-derived xenograft (PDX) tumor models represent a valuable platform for identifying new biomarkers and novel targets, to evaluate therapy response and resistance mechanisms. This study aimed at establishment, characterization and therapy testi
Externí odkaz:
https://doaj.org/article/d76f77186ff440aeb1039269f77ac9db
Autor:
Alexander Arnold, Moritz Tronser, Christine Sers, Ayel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Michael Kloor, Hendrik Bläker
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Prev
Externí odkaz:
https://doaj.org/article/407566c77f1d4a7485b2fedafcd37fb6
Autor:
Soulafa Mamlouk, Tincy Simon, Laura Tomás, David C. Wedge, Alexander Arnold, Andrea Menne, David Horst, David Capper, Markus Morkel, David Posada, Christine Sers, Hendrik Bläker
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background Colorectal cancer (CRC) development is generally accepted as a sequential process, with genetic mutations determining phenotypic tumor progression. However, matching genetic profiles with histological transition requires the analy
Externí odkaz:
https://doaj.org/article/b6b57712417e4b15ab41fe27ab926615
Autor:
Bertram Wiedenmann, Tom Luedde, Frank Tacke, Linda Hammerich, Christoph Roderburg, Katharina Detjen, Raik Otto, Yvonne Giesecke, Lukas Geisler, Pamela Riemer, Henning Jann, Carsten Grötzinger, Christine Sers, Ulf Leser, Michael Sigal
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/157eb3c3b6aa4679bea3534f33cc367c