Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Christine, Orr"'
Autor:
Xiaowei Xu, Hao Wang, Michael Tetzlaff, James Ziai, Sabina Signoretti, Ashley Cimino-Mathews, Tricia Cottrell, Janis M Taube, Annikka Weissferdt, Richard A Scolyer, Pierre-Olivier Fiset, Jaime Rodriguez-Canales, Lynette M Sholl, Julie S Deutsch, Krista Chen, Carlos E de Andrea, Christine Orr, Salgado Roberto, Christian Schurch, Raja Seethala, Alexander S Baras
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 2 (2023)
Externí odkaz:
https://doaj.org/article/43e08721fce4413f885d76cce4d9f3a9
Publikováno v:
eJHaem, Vol 2, Iss 3, Pp 672-673 (2021)
Externí odkaz:
https://doaj.org/article/511acc8ae6094700909c443ce0e96e7f
Autor:
Daniel C. Kirouac, Gabriele Schaefer, Jocelyn Chan, Mark Merchant, Christine Orr, Shih-Min A. Huang, John Moffat, Lichuan Liu, Kapil Gadkar, Saroja Ramanujan
Publikováno v:
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-17 (2017)
Systems pharmacology:Predicting efficacy of novel anti-cancer drugs in colorectal cancer While cancer drug development relies on experimental tumor models for testing, results observed in these systems often fail to translate clinically. Kirouac et a
Externí odkaz:
https://doaj.org/article/6bfc02d0615b4d33ac88a7be2e3e419b
Autor:
José, Jessurun, Christine, Orr, Samantha N, McNulty, Catherine E, Hagen, Hussein, Alnajar, David, Wilkes, Sarah, Kudman, Majd, Al Assaad, Princesca, Dorsaint, Kentaro, Ohara, Feng, He, Kenrry, Chu, Yong Mei, Yin, Jenny Zhaoying, Xiang, Lihui, Qin, Andrea, Sboner, Olivier, Elemento, Rhonda K, Yantiss, Rondell P, Graham, Flora, Poizat, Juan Miguel, Mosquera
Publikováno v:
American Journal of Surgical Pathology. 47:65-73
GLI1 encodes a transcription factor that targets cell cycle regulators affecting stem cell proliferation. GLI1 gene fusions were initially described in pericytomas with a t[7;12] translocation and more recently in gastric plexiform fibromyxomas and g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456b579b1834a67d61866ce48cde5803
https://doi.org/10.1097/pas.0000000000001950
https://doi.org/10.1097/pas.0000000000001950
Autor:
Marcia Belvin, Lori S. Friedman, Stuart Johnston, Stefan Engst, Nai-Ying Yang, Ken Rice, Hartmut Koeppen, Ian Kasman, Leanne Berry, Doug Den Otter, Jocelyn Chan, Christine Orr, Mark Merchant, Klaus P. Hoeflich
PDF file - 1.1MB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01fe3259b57795559bced220bd598067
https://doi.org/10.1158/0008-5472.22392657
https://doi.org/10.1158/0008-5472.22392657
Autor:
Marcia Belvin, Lori S. Friedman, Stuart Johnston, Stefan Engst, Nai-Ying Yang, Ken Rice, Hartmut Koeppen, Ian Kasman, Leanne Berry, Doug Den Otter, Jocelyn Chan, Christine Orr, Mark Merchant, Klaus P. Hoeflich
PDF file - 68K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c44537a71621ec7596b40ce2c536dc0
https://doi.org/10.1158/0008-5472.22392660.v1
https://doi.org/10.1158/0008-5472.22392660.v1
Autor:
Mark Merchant, John Moffat, Gabriele Schaefer, Jocelyn Chan, Xi Wang, Christine Orr, Jason Cheng, Thomas Hunsaker, Lily Shao, Stephanie J Wang, Marie-Claire Wagle, Eva Lin, Peter M Haverty, Sheerin Shahidi-Latham, Hai Ngu, Margaret Solon, Jeffrey Eastham-Anderson, Hartmut Koeppen, Shih-Min A Huang, Jacob Schwarz, Marcia Belvin, Daniel Kirouac, Melissa R Junttila
Publikováno v:
PLoS ONE, Vol 13, Iss 1, p e0192059 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0185862.].
Externí odkaz:
https://doaj.org/article/f19d049196ac4e549fd26d5e8c910736
Autor:
Mark Merchant, John Moffat, Gabriele Schaefer, Jocelyn Chan, Xi Wang, Christine Orr, Jason Cheng, Thomas Hunsaker, Lily Shao, Stephanie J Wang, Marie-Claire Wagle, Eva Lin, Peter M Haverty, Sheerin Shahidi-Latham, Hai Ngu, Margaret Solon, Jeffrey Eastham-Anderson, Hartmut Koeppen, Shih-Min A Huang, Jacob Schwarz, Marcia Belvin, Daniel Kirouac, Melissa R Junttila
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185862 (2017)
Mitogen-activated protein kinase (MAPK) pathway dysregulation is implicated in >30% of all cancers, rationalizing the development of RAF, MEK and ERK inhibitors. While BRAF and MEK inhibitors improve BRAF mutant melanoma patient outcomes, these inhib
Externí odkaz:
https://doaj.org/article/5f261879e7284434b9f12d96e885ff3d
Autor:
Darlene Dela Cruz, Mark Merchant, Frances Shanahan, Christopher J. Sneeringer, Paul Gibbons, Shiva Malek, Michael Siu, Matthew R. Durk, Weiru Wang, John Moffat, Jianping Yin, Thomas Hunsaker, Liu Wendy, Dennis Leung, Ivana Yen, Charles Eigenbrot, Joachim Rudolph, Christine S Muli, Hank La, Brendan T. Parr, Antonio G. DiPasquale, Malcolm P. Huestis, Alberto Gobbi, Christine Orr
Publikováno v:
Journal of Medicinal Chemistry. 64:3940-3955
Optimization of a series of aryl urea RAF inhibitors led to the identification of type II pan-RAF inhibitor GNE-0749 (7), which features a fluoroquinazolinone hinge-binding motif. By minimizing reliance on common polar hinge contacts, this hinge bind
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5caf4fa1983e44c0d9c529885c02901c
https://doi.org/10.1021/acs.jmedchem.0c02085
https://doi.org/10.1021/acs.jmedchem.0c02085
Autor:
Ahmed Salem, Yan Shi, Aparna Raval, Mark Merchant, Tamar Uziel, Frederick J. Kohlhapp, Jacob J Riehm, Deepak Sampath, Elisabeth A. Lasater, Dipica Haribhai, Joel D. Leverson, Rebecca Mathew, Valerie A. Robinson, William N. Pappano, Christine Orr, Yijin Li, Anahita Bhathena, Keith M. Hamel, Nimita Dave, An D. Do, Cherrie K. Donawho, Paul A. Ellis, Ryan Duggan, Rui Wang
Publikováno v:
Cancer Discovery. 11:68-79
The antiapoptotic protein BCL2 plays critical roles in regulating lymphocyte development and immune responses, and has also been implicated in tumorigenesis and tumor survival. However, it is unknown whether BCL2 is critical for antitumor immune resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f58391c3ee015fd579955202af8160b
https://doi.org/10.1158/2159-8290.cd-19-0759
https://doi.org/10.1158/2159-8290.cd-19-0759