BMP9, but not BMP10, acts as a quiescence factor on tumor growth, vessel normalization and metastasis in a mouse model of breast cancer

Autor: Marie Ouarné, Claire Bouvard, Gabriela Boneva, Christine Mallet, Johnny Ribeiro, Agnès Desroches-Castan, Emmanuelle Soleilhac, Emmanuelle Tillet, Olivier Peyruchaud, Sabine Bailly

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-12 (2018)

Abstract Background Angiogenesis has become an attractive target for cancer therapy. However, despite the initial success of anti-VEGF (Vascular endothelial growth factor) therapies, the overall survival appears only modestly improved and resistance

Externí odkaz: https://doaj.org/article/eb7e53d2b5f4496c98fedda5fd0bd936

Different cardiovascular and pulmonary phenotypes for single- and double-knock-out mice deficient in BMP9 and BMP10

Autor: Nihel Berrebeh, Emmanuelle Tillet, Hequn Liu, Christophe Guignabert, Ly Tu, Sabine Bailly, Christophe Battail, Martina Rossi, Nicolas Chaumontel, Marie Ouarné, Laurent Savale, Thomas Daubon, Marc Humbert, Agnès Desroches-Castan, Christine Mallet, Caroline Roelants, Elise Helfer, Claire Bouvard, Pascale Perret, Andreas Bikfalvi

Publikováno v: Cardiovascular Research
Cardiovascular Research, 2021, ⟨10.1093/cvr/cvab187⟩
Cardiovascular Research, 2021, pp.cvab187. ⟨10.1093/cvr/cvab187⟩
Cardiovascular Research, Oxford University Press (OUP), 2021, ⟨10.1093/cvr/cvab187⟩
Cardiovascular Research, Oxford University Press (OUP), 2021, pp.cvab187. ⟨10.1093/cvr/cvab187⟩

Aims BMP9 and BMP10 mutations were recently identified in patients with pulmonary arterial hypertension, but their specific roles in the pathogenesis of the disease are still unclear. We aimed to study the roles of BMP9 and BMP10 in cardiovascular ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80d461b345d64ba507813f933802413
https://doi.org/10.1093/cvr/cvab187

Selective BMP-9 Inhibition Partially Protects Against Experimental Pulmonary Hypertension

Autor: Raphaël Thuillet, Alice Huertas, Carole Phan, Ayumi Sekine, Christine Mallet, Ly Tu, Sabine Bailly, Christophe Guignabert, Laurent Savale, Olli Ritvos, Florian Robert, Jennifer Bordenave, Laurent Guyon, Agnès Desroches-Castan, Marc Humbert, Jean-Jacques Feige, Amélie Cumont

Publikováno v: Circulation Research
Circulation Research, American Heart Association, 2019, 124 (6), pp.846-855. ⟨10.1161/CIRCRESAHA.118.313356⟩
HAL
Circulation Research, American Heart Association, 2019
Circulation Research, 2019, 124 (6), pp.846-855. ⟨10.1161/CIRCRESAHA.118.313356⟩
Circulation Research, 2019

Rationale: Although many familial cases of pulmonary arterial hypertension exhibit an autosomal dominant mode of inheritance with the majority having mutations in essential constituents of the BMP (bone morphogenetic protein) signaling, the specific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5789222560e2a2270f911fd3b3f1fe5e
https://www.hal.inserm.fr/inserm-02581297/document

A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma

Autor: Emmanuelle, Tillet, Marie, Ouarné, Agnès, Desroches-Castan, Christine, Mallet, Mariela, Subileau, Robin, Didier, Anna, Lioutsko, Guillaume, Belthier, Jean-Jacques, Feige, Sabine, Bailly

Publikováno v: The Journal of biological chemistry. 293(28)

Bone morphogenetic protein 9 (BMP9) and BMP10 are the two high-affinity ligands for the endothelial receptor activin receptor-like kinase 1 (ALK1) and are key regulators of vascular remodeling. They are both present in the blood, but their respective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a72f5f2e0daf4196c68f3453a34e0afa
https://pubmed.ncbi.nlm.nih.gov/29789425

Functional analysis of endoglin mutations from hereditary hemorrhagic telangiectasia type 1 patients reveals different mechanisms for endoglin loss of function

Autor: Christine Mallet, Emmanuelle Tillet, Sabine Bailly, Sophie Giraud, Sophie Dupuis-Girod, Jean-Jacques Feige, Khadija Lamribet

Publikováno v: Human Molecular Genetics. 24:1142-1154

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant inheritable vascular dysplasia caused by mutations in genes encoding either endoglin or activin receptor-like kinase-1 (ALK1). Functional significance of endoglin missense mutations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f03142bc67e171d7e319c72f29a39a8
https://doi.org/10.1093/hmg/ddu531