Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Christine, Garnett"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 8, Iss 6, Pp 371-379 (2019)
As a relatively new discipline, quantitative systems pharmacology has seen a significant increase in the application and utility of drug development. One area that could greatly benefit from such an approach is in the proarrhythmia assessment of new
Externí odkaz:
https://doaj.org/article/60d21dc659434b88ac8b2ee505b68786
Autor:
Katerina Hnatkova, Jose Vicente, Lars Johannesen, Christine Garnett, David G. Strauss, Norman Stockbridge, Marek Malik
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Electrocardiogram (ECG) studies of drug-induced prolongation of the interval between the J point and the peak of the T wave (JTp interval) distinguished QT prolonging drugs that predominantly block the delayed potassium rectifier current from those a
Externí odkaz:
https://doaj.org/article/1e461617088940808e5f417929811e2f
Autor:
Katerina Hnatkova, Jose Vicente, Lars Johannesen, Christine Garnett, Norman Stockbridge, Marek Malik
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
The accuracy of studies of drug-induced QTc changes depends, among others, on the accuracy of heart rate correction of QT interval. It has been recognized that when a drug leads to substantial heart rate changes, fixed universal corrections cannot be
Externí odkaz:
https://doaj.org/article/25a5d8d4e3804103a71d2b5f3e849551
Autor:
Cécile Ollivier, Haihao Sun, Wayne Amchin, Maurice Beghetti, Rolf M. F. Berger, Stefanie Breitenstein, Christine Garnett, Ninna Gullberg, Patrik Hassel, Dunbar Ivy, Steven M. Kawut, Agnes Klein, Catherine Lesage, Marek Migdal, Barbara Nije, Michal Odermarsky, James Strait, Pieter A. de Graeff, Norman Stockbridge
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 10 (2019)
Externí odkaz:
https://doaj.org/article/703b105f8aba4116b102ce695a9d3ef0
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 203:726-736
Rationale: Event-driven primary endpoints are increasingly used in pulmonary arterial hypertension clinical trials, substantially increasing required sample sizes and trial lengths. The U.S. Food a...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45ffa41dd9eea24908efa4154940e3b0
https://doi.org/10.1164/rccm.202002-0357oc
https://doi.org/10.1164/rccm.202002-0357oc
Autor:
Christine Garnett, Norman Stockbridge
Publikováno v:
Advances in Pulmonary Hypertension. 19:62-65
Pulmonary arterial hypertension (PAH) is a rare, progressive disease. There are 11 drugs available in the United States to treat adult PAH patients; however, all drugs primarily act through vasodilation and have modest effects on clinical endpoints.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05b9a516e06d1edadf32041f2793d5b6
https://doi.org/10.21693/1933-088x-19.2.62
https://doi.org/10.21693/1933-088x-19.2.62
Autor:
Jean-Pierre Valentin, Peter Hoffmann, Catherine Ortemann-Renon, John Koerner, Jennifer Pierson, Gary Gintant, James Willard, Christine Garnett, Matthew Skinner, Hugo M Vargas, Todd Wisialowski, Michael K Pugsley
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 187(1)
The content of this article derives from a Health and Environmental Sciences Institute (HESI) consortium with a focus to improve cardiac safety during drug development. A detailed literature review was conducted to evaluate the concordance between no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c1bab76e6e11698e6ce6d673f29f20d
https://pubmed.ncbi.nlm.nih.gov/35148401
https://pubmed.ncbi.nlm.nih.gov/35148401
Publikováno v:
Journal of Electrocardiology. 73:24-25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::805ef45e1fd3d16b8a2ec2f26456241e
https://doi.org/10.1016/j.jelectrocard.2022.07.058
https://doi.org/10.1016/j.jelectrocard.2022.07.058
Autor:
Kalyanam Shivkumar, Frank A.J.L. Scheer, Alfred L. George, Martica H. Hall, Virend K. Somers, Martin E. Young, Christine Garnett, Prince J. Kannankeril, Steven Shea, Crystal M. Ripplinger, Joshua I. Goldhaber, Jeanne M. Nerbonne, Michael H. Smolensky, Joseph Bass, Tracey O. Hermanstyne, Jeanne F. Duffy, Mukesh K. Jain, Ron C. Anafi, Ravi C. Balijepalli, Brian P. Delisle
Publikováno v:
Circulation. Arrhythmia and electrophysiology, vol 14, iss 11
Circ Arrhythm Electrophysiol
Circ Arrhythm Electrophysiol
Sudden cardiac death (SCD) is the sudden, unexpected death due to abrupt loss of heart function secondary to cardiovascular disease. In certain populations living with cardiovascular disease, SCD follows a distinct 24-hour pattern in occurrence, sugg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c73b0828418116c4c3eabacdf796463
https://doi.org/10.1161/circep.121.010190
https://doi.org/10.1161/circep.121.010190
Autor:
Frank A.J.L. Scheer, Michael H. Smolensky, Tracey O. Hermanstyne, Martin E. Young, Martica H. Hall, Brian P. Delisle, Joshua I. Goldhaber, Prince J. Kannankeril, Steven Shea, Alfred L. George, Ron C. Anafi, Christine Garnett, Kalyanam Shivkumar, Jeanne F. Duffy, Ravi C. Balijepalli, Joseph Bass, Mukesh K. Jain, Jeanne M. Nerbonne, Virend K. Somers, Crystal M. Ripplinger
Publikováno v:
Circulation. Arrhythmia and electrophysiology, vol 14, iss 11
Circ Arrhythm Electrophysiol
Circ Arrhythm Electrophysiol
Sudden cardiac death (SCD), the unexpected death due to acquired or genetic cardiovascular disease, follows distinct 24-hour patterns in occurrence. These 24-hour patterns likely reflect daily changes in arrhythmogenic triggers and the myocardial sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a06dc3b9432a6bc9c96bc83a2675d57
https://escholarship.org/uc/item/1d08n3b0
https://escholarship.org/uc/item/1d08n3b0
