Retinoic Acid Receptors Control Spermatogonia Cell-Fate and Induce Expression of the SALL4A Transcription Factor.

Autor: Aurore Gely-Pernot, Mathilde Raverdeau, Marius Teletin, Nadège Vernet, Betty Féret, Muriel Klopfenstein, Christine Dennefeld, Irwin Davidson, Gérard Benoit, Manuel Mark, Norbert B Ghyselinck

Publikováno v: PLoS Genetics, Vol 11, Iss 10, p e1005501 (2015)

All-trans retinoic acid (ATRA) is instrumental to male germ cell differentiation, but its mechanism of action remains elusive. To address this question, we have analyzed the phenotypes of mice lacking, in spermatogonia, all rexinoid receptors (RXRA,

Externí odkaz: https://doaj.org/article/026cd909116a4bf8b3f862480888660d

Spermatogonia Differentiation Requires Retinoic Acid Receptor γ

Autor: Mathilde Raverdeau, Norbert B. Ghyselinck, Christine Dennefeld, Aurore Gely-Pernot, Shosei Yoshida, Muriel Klopfenstein, Manuel Mark, Betty Feret, Catherine Celebi

Publikováno v: Endocrinology
Endocrinology, Endocrine Society, 2012, 153 (1), pp.438-449. ⟨10.1210/en.2011-1102⟩
Endocrinology, 2012, 153 (1), pp.438-449. ⟨10.1210/en.2011-1102⟩

International audience; Vitamin A is instrumental to mammalian reproduction. Its metabolite, retinoic acid (RA), acts in a hormone-like manner through binding to and activating three nuclear receptor isotypes, RA receptor (RAR)α (RARA), RARβ, and R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8638b7d3acb3b736b340f2945324bffc
https://doi.org/10.1210/en.2011-1102

Contribution of cellular retinol-binding protein type 1 to retinol metabolism during mouse development

Autor: Christine Dennefeld, Heinz Nau, Valérie Dupé, Pierre Chambon, Nicolas Matt, Manuel Mark, Carsten K. Schmidt, Norbert B. Ghyselinck

Publikováno v: Developmental Dynamics. 233:167-176

Within cells, retinol (ROL) is bound to cytoplasmic proteins (cellular retinol-binding proteins [CRBPs]), whose proposed function is to protect it from unspecific enzymes through channeling to retinoid-metabolizing pathways. We show that, during deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd4eefc28921c04b3e2ca029b00f5051
https://doi.org/10.1002/dvdy.20313

Retinoic acid induces Sertoli cell paracrine signals for spermatogonia differentiation but cell autonomously drives spermatocyte meiosis

Autor: Norbert B. Ghyselinck, Manuel Mark, Pierre Chambon, Mathilde Raverdeau, Christine Dennefeld, Aurore Gely-Pernot, Irwin Davidson, Gérard Benoit, Betty Féret

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2012, 109 (41), pp.16582-7. ⟨10.1073/pnas.1214936109⟩

Direct evidence for a role of endogenous retinoic acid (RA), the active metabolite of vitamin A in the initial differentiation and meiotic entry of spermatogonia, and thus in the initiation of spermatogenesis is still lacking. RA is synthesized by de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a40ba6e935f3ccd67f709013429a82dc
https://hal.archives-ouvertes.fr/hal-00749600

Retinoic acid drives aryl hydrocarbon receptor expression and is instrumental to dioxin-induced toxicity during palate development

Autor: Matti Viluksela, Hugues Jacobs, Helen Håkansson, Christine Dennefeld, Norbert B. Ghyselinck, Manuel Mark, Betty Féret

Publikováno v: Environmental Health Perspectives

Background: Palate development depends on complex events and is very sensitive to disruption. Accordingly, clefts are the most common congenital malformations worldwide, and a connection is proposed with fetal exposure to toxic factors or environment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c0443758c1daec8216bbd98418b0652
https://pubmed.ncbi.nlm.nih.gov/21807577