Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Christine, Butler"'
Autor:
Eimear Mylod, Fiona O’Connell, Noel E. Donlon, Maria Davern, Caroline Marion, Christine Butler, John V. Reynolds, Joanne Lysaght, Melissa J. Conroy
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract Oesophagogastric adenocarcinomas (OAC) are poor prognosis, obesity-associated cancers which may benefit from natural killer (NK) cell-based immunotherapies. Cellular immunotherapies encounter two key challenges to their success in OAC, namel
Externí odkaz:
https://doaj.org/article/893b5ecdb958437faa29914c40f247e8
Autor:
Maria Davern, Cillian O’ Donovan, Noel E. Donlon, Eimear Mylod, Caoimhe Gaughan, Anshul Bhardwaj, Andrew D. Sheppard, Dara Bracken-Clarke, Christine Butler, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Melissa J. Conroy
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 819 (2024)
The presence of an immunosuppressive tumour microenvironment in oesophageal adenocarcinoma (OAC) is a major contributor to poor responses. Novel treatment strategies are required to supplement current regimens and improve patient survival. This study
Externí odkaz:
https://doaj.org/article/3ca4eb6b6a0845a7a2adb872372af596
Autor:
Maria Davern, Caoimhe Gaughan, Fiona O’ Connell, Brendan Moran, Eimear Mylod, Andrew D. Sheppard, Sinead Ramjit, Jasmine Yun-Tong Kung, James J. Phelan, Matthew G. Davey, Eanna J. Ryan, Christine Butler, Laura Quinn, Claudine Howard, Emily Tone, Eimear Phoenix, Waqas T. Butt, Niamh Lynam-Lennon, Stephen G. Maher, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght, Noel E. Donlon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThis timely study assesses the immunosuppressive effects of surgery on cytotoxic Th1-like immunity and investigates if immune checkpoint blockade (ICB) can boost Th1-like immunity in the perioperative window in upper gastrointestinal canc
Externí odkaz:
https://doaj.org/article/e9a76b77fe4448bca0dc1485f4477ae2
Autor:
Maria Davern, Noel E. Donlon, Fiona O’ Connell, Andrew D. Sheppard, Conall Hayes, Ross King, Hugo Temperley, Christine Butler, Anshul Bhardwaj, Jenny Moore, Dara Bracken-Clarke, Claire Donohoe, Narayanasamy Ravi, John V. Reynolds, Stephen G. Maher, Melissa J. Conroy, Joanne Lysaght
Publikováno v:
Translational Oncology, Vol 20, Iss , Pp 101406- (2022)
Response rates to immune checkpoint blockade (ICB) remain low in oesophageal adenocarcinoma (OAC). Combining ICB with immunostimulatory chemotherapies to boost response rates is an attractive approach for converting ‘cold’ tumours into ‘hot’
Externí odkaz:
https://doaj.org/article/c52c824c793a4acdab0d58f23a41159d
Autor:
Noel E. Donlon, Maria Davern, Andrew D. Sheppard, Fiona O’Connell, Margaret R. Dunne, Conall Hayes, Eimear Mylod, Sinead Ramjit, Hugo Temperley, Michael Mac Lean, Gillian Cotter, Anshul Bhardwaj, Christine Butler, Melissa J. Conroy, Jacintha O’Sullivan, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundImmune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains unknown. Our study profiles systemic
Externí odkaz:
https://doaj.org/article/c1c43e80139b48f2bdb847aa34f8da63
Autor:
Maria Davern, Noel E. Donlon, Fiona O’Connell, Caoimhe Gaughan, Cillian O’Donovan, Mohammed Habash, Andrew D. Sheppard, Michael MacLean, Margaret R. Dunne, Jenny Moore, Hugo Temperley, Melissa J. Conroy, Christine Butler, Anshul Bhardwaj, Narayanasamy Ravi, Claire L. Donohoe, John V. Reynolds, Joanne Lysaght
Publikováno v:
Cancer Immunology, Immunotherapy. 72:55-71
Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study investigated the effect of ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be424e297392a657451ea0876b74eede
https://doi.org/10.1007/s00262-022-03228-y
https://doi.org/10.1007/s00262-022-03228-y
Autor:
Noel E, Donlon, Maria, Davern, Fiona, O'Connell, Andrew, Sheppard, Aisling, Heeran, Anshul, Bhardwaj, Christine, Butler, Ravi, Narayanasamy, Claire, Donohoe, James J, Phelan, Niamh, Lynam-Lennon, Margaret R, Dunne, Stephen, Maher, Jacintha, O'Sullivan, John V, Reynolds, Joanne, Lysaght
Publikováno v:
World Journal of Gastroenterology. 28:2302-2319
In the contemporary era of cancer immunotherapy, an abundance of clinical and translational studies have reported radiotherapy (RT) and immunotherapies as a viable option for immunomodulation of many cancer subtypes, with many related clinical trials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df5d7de08595924a4e2f5c7b697d8a48
https://doi.org/10.3748/wjg.v28.i21.2302
https://doi.org/10.3748/wjg.v28.i21.2302
Autor:
Maria Davern, Dara Bracken-Clarke, Noel E Donlon, Andrew D Sheppard, Fiona O connell, Aisling B Heeran, Klaudia Majcher, Melissa J Conroy, Eimear Mylod, Christine Butler, Claire Donohoe, Dearbhaile O' Donnell, Maevle Lowry, Anshul Bhardwaj, Narayanasamy Ravi, Ashanty A Melo, Jacintha O' Sullivan, John V Reynolds, Joanne Lysaght
Publikováno v:
Journal of Cancer Research and Clinical Oncology.
Aim Visceral obesity is a key risk factor in the development of oesophagogastric junctional adenocarcinoma (OGJ), predominantly via generation of systemic low grade inflammation. Obesity-induced inflammation promotes resistance to current standards o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83ee785ba1b3b17cbf658ad9fc57488
https://doi.org/10.1007/s00432-023-04620-6
https://doi.org/10.1007/s00432-023-04620-6
Autor:
Eimear Mylod, Fiona O’Connell, Noel E. Donlon, Christine Butler, John V. Reynolds, Joanne Lysaght, Melissa J. Conroy
Publikováno v:
Cancers, Vol 14, Iss 64, p 64 (2022)
Cancers; Volume 14; Issue 1; Pages: 64
Cancers
Cancers; Volume 14; Issue 1; Pages: 64
Cancers
Simple Summary Oesophagogastric adenocarcinomas (OAC) are cancers of the food pipe and stomach which have a strong link with obesity. Natural killer (NK) cells are assassins of the immune system and are crucial for eliminating cancer. We have shown p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f49cf9d3b7be14c7e1c9ad4579f7848
https://www.mdpi.com/2072-6694/14/1/64
https://www.mdpi.com/2072-6694/14/1/64
Autor:
Christine Butler-Minor
Monitoring habitat conditions in the Clear Creek Estuary before the completion of the Bucklin Hill Bridge Project is a critical part of this ecosystem restoration planning and execution. The Clear Creek Trail Alliance (CCTA) is working with local par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b03904b89f2d3a95c53273cf8df35844
https://doi.org/10.15760/mem.54
https://doi.org/10.15760/mem.54
