Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Christina Zimmer"'
Autor:
Carolin Baedeker, Justus von Geibler, Benjamin Krisemendt, Philipp Themann, Christina Zimmer, Viktor Grinewitschus, Julius Piwowar, Katja Lepper
Publikováno v:
Sustainability, Vol 12, Iss 6956, p 6956 (2020)
Sustainability
Volume 12
Issue 17
Sustainability 12(17), 6956 (2020). doi:10.3390/su12176956
Sustainability
Volume 12
Issue 17
Sustainability 12(17), 6956 (2020). doi:10.3390/su12176956
Many technical solutions have been developed to enhance the energy efficiency in buildings. However, the actual effectiveness and sustainability of these solutions often do not correspond to expectations because of the missing perspective of design,
Autor:
Rolf W. Hartmann, Alessandra Bisi, Federica Belluti, Angela Rampa, Christina Zimmer, Silvia Gobbi, Qingzhong Hu
Publikováno v:
European Journal of Medicinal Chemistry. 139:60-67
An abnormal increase in glucocorticoid levels is responsible for pathological disorders affecting different organs and systems, and the selective inhibition of appropriate steroidogenic enzymes represents a validated strategy to restore their physiol
Autor:
Qingzhong Hu, Alessandra Bisi, Federica Belluti, Angela Rampa, Silvia Gobbi, Christina Zimmer, Rolf W. Hartmann
Publikováno v:
ChemMedChem. 11:1770-1777
Abnormally high corticosteroid levels are responsible for the onset of serious hormone-related diseases, and the inhibition of their biosynthesis by targeting cytochrome P450 (CYP) isoforms CYP11B1 and CYP11B2 has emerged as a promising strategy to r
Autor:
Christina Zimmer, Alessandra Bisi, Rolf W. Hartmann, Qingzhong Hu, Silvia Gobbi, Matthias Negri, Federica Belluti, Angela Rampa
Publikováno v:
Journal of Medicinal Chemistry. 56:1723-1729
Imidazolylmethylflavones previously reported by us as aromatase inhibitors proved to be able to interact with aldosterone synthase (CYP11B2), a cytochrome P450 enzyme involved in the biosynthesis of the mineralcorticoid hormone aldosterone, and were
Autor:
Alessandra Bisi, Rolf W. Hartmann, Federica Belluti, Angela Rampa, Matthias Engel, Qingzhong Hu, Silvia Gobbi, Christina Zimmer
Publikováno v:
Journal of medicinal chemistry. 59(6)
The inhibition of corticosteroid biosynthesis could be considered as an emerging strategy to reduce their abnormally high levels, and in this framework CYP11B1 and CYP11B2 represent the most promising targets. In continuing our studies on flavonoid-l
Publikováno v:
Medicinal Chemistry Research. 22:692-698
Imidazolyl substituted 16E-arylidenosteroidal derivatives have been synthesized and evaluated for aromatase inhibitory activity. The steroidal hybrids displayed moderate inhibition of the aromatase enzyme. The enzyme activity was monitored by measuri
Autor:
Claudia Henn, Benjamin Kirsch, Johannes C. de Jong, Christina Zimmer, Cenbin Lu, Christine K. Maurer, Susanne Häussler, Anke Steinbach, Rolf W. Hartmann, Mathias Müsken
Publikováno v:
Chemistry & Biology. 19:381-390
Summary The pqs quorum sensing communication system of Pseudomonas aeruginosa controls virulence factor production and is involved in biofilm formation, therefore playing an important role for pathogenicity. In order to attenuate P. aeruginosa pathog
Synthesis and Preliminary Screening of Novel A- and D-Ring Modified Steroids as Aromatase Inhibitors
Autor:
Mange Ram Yadav, Prafulla M. Sabale, Rolf W. Hartmann, Rajani Giridhar, Dharmendra Baria, Christina Zimmer
Publikováno v:
Letters in Drug Design & Discovery. 8:943-950
Autor:
Mange Ram Yadav, Rolf W. Hartmann, Rajani Giridhar, Jörg Haupenthal, Prafulla M. Sabale, Christina Zimmer
Publikováno v:
Steroids. 76:464-470
Novel pyrazole and isoxazole derivatives (6-9) were synthesized as a aromatase inhibitors. Pyrazole was synthesized from hydrazine hydrate and isoxazoles from hydroxylamine hydrochloride under different conditions. Molecular docking studies were carr