Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Christina Z. Chung"'
Autor:
Pearl Morosky, Cody Comyns, Lance G. A. Nunes, Christina Z. Chung, Peter R. Hoffmann, Dieter Söll, Oscar Vargas-Rodriguez, Natalie Krahn
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Post-translational modifications (PTMs) can occur on almost all amino acids in eukaryotes as a key mechanism for regulating protein function. The ability to study the role of these modifications in various biological processes requires techniques to
Externí odkaz:
https://doaj.org/article/11feafb19d6744eebafcd976e48d9b77
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Genetic code expansion strategies are limited to specific codons that can be reassigned to new amino acids. Here the authors show that quadruplet-decoding tRNAs (qtRNAs) can be rapidly discovered and evolved to decode new quadruplet codons, enabling
Externí odkaz:
https://doaj.org/article/160d7d8ec84743218f1d2a710d9af0a0
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Archaea constitute the third domain of life, distinct from bacteria and eukaryotes given their ability to tolerate extreme environments. To survive these harsh conditions, certain archaeal lineages possess unique genetic code systems to encode either
Externí odkaz:
https://doaj.org/article/5d01ad1513074ef2ac79b8f5ff9817e2
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Protein identification has gone beyond simply using protein/peptide tags and labeling canonical amino acids. Genetic code expansion has allowed residue- or site-specific incorporation of non-canonical amino acids into proteins. By taking advantage of
Externí odkaz:
https://doaj.org/article/cf1f2488a5724d46a38d70da3fc2375e
Autor:
Han-Kai Jiang, Nicole L. Ambrose, Christina Z. Chung, Yane-Shih Wang, Dieter Söll, Jeffery M. Tharp
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Synthetic biology tools for regulating gene expression have many useful biotechnology and therapeutic applications. Most tools developed for this purpose control gene expression at the level of transcription, and relatively few methods are available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbd3b1a29979a39997a79bcd480f6015
https://doi.org/10.1073/pnas.2219758120
https://doi.org/10.1073/pnas.2219758120
Publikováno v:
Journal of molecular biology, vol. 433, pp. 1-16, 2021.
J Mol Biol
J Mol Biol
The presence of selenocysteine in a protein confers many unique properties that make the production of recombinant selenoproteins desirable. Targeted incorporation of Sec into a protein of choice is possible by exploiting elongation factor Tu-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1570832e4db9f8c7c47a4bdd48e6c4
https://hdl.handle.net/20.500.12556/DiRROS-14967
https://hdl.handle.net/20.500.12556/DiRROS-14967
Publikováno v:
Methods Enzymol
The unique properties of selenocysteine (Sec) have generated an interest in the scientific community to site-specifically incorporate Sec into a protein of choice. Current technologies have rewired the natural Sec-specific translation factor-dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::17b8fefd17fceaf2cd0839f4a54c6155
https://pubmed.ncbi.nlm.nih.gov/35101219
https://pubmed.ncbi.nlm.nih.gov/35101219
Publikováno v:
Methods in Enzymology ISBN: 9780323907354
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98cff015d3512f1ff06747426e1e82c1
https://doi.org/10.1016/bs.mie.2021.10.005
https://doi.org/10.1016/bs.mie.2021.10.005
Publikováno v:
Curr Protoc
Selenoproteins contain the 21st amino acid, selenocysteine. Selenocysteine is the only amino acid that is synthesized on its cognate tRNA, and it is inserted at specific recoded UGA stop codons via a complex translation system. Although highly simila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51f74fc3f9fbc84b90e9c2622961c04
https://europepmc.org/articles/PMC7972002/
https://europepmc.org/articles/PMC7972002/
Autor:
Ilka U. Heinemann, Mallory I. Frederick, Christina Z. Chung, Tarana Siddika, Nileeka Balasuriya
Publikováno v:
RNA Biol
In the cell, RNA abundance is dynamically controlled by transcription and decay rates. Posttranscriptional nucleotide addition at the RNA 3ʹ end is a means of regulating mRNA and RNA stability and activity, as well as marking RNAs for degradation. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6a1cb883b6b8b8dcab6deb774fd2b3