Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Christina Yap"'
Autor:
Emily Alger, Mary Van Zyl, Olalekan Lee Aiyegbusi, Dave Chuter, Lizzie Dean, Anna Minchom, Christina Yap
Publikováno v:
Research Involvement and Engagement, Vol 10, Iss 1, Pp 1-9 (2024)
Abstract Background In light of the FDA’s Project Optimus initiative, there is fresh interest in leveraging Patient-reported Outcome (PRO) data to enhance the assessment of tolerability for investigational therapies within early phase dose-finding
Externí odkaz:
https://doaj.org/article/a5cb45ec14b9497e9b1481114ed722e1
Autor:
Cindy Cooper, Katie Biggs, Alexander Rothman, Christina Yap, Fiona Thistlethwaite, Della Ogunleye, Munyaradzi Dimairo, Robin Chatters, Shamila Ditta, Jonathan Woodward
Publikováno v:
BMJ Open, Vol 14, Iss 3 (2024)
Objectives To explore the importance of, and barriers to achieving, diversity in early-phase clinical trials.Design Qualitative interviews analysed using thematic analysis.Setting and participants Five professionals (clinical researchers and methodol
Externí odkaz:
https://doaj.org/article/674fc1be3ed945029b5589455bc890a0
Autor:
Martin Law, Dominique-Laurent Couturier, Babak Choodari-Oskooei, Phillip Crout, Carrol Gamble, Peter Jacko, Philip Pallmann, Mark Pilling, David S. Robertson, Michael Robling, Matthew R. Sydes, Sofía S. Villar, James Wason, Graham Wheeler, S. Faye Williamson, Christina Yap, Thomas Jaki
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-5 (2023)
Abstract In the UK, the Medicines and Healthcare products Regulatory Agency consulted on proposals “to improve and strengthen the UK clinical trials legislation to help us make the UK the best place to research and develop safe and innovative medic
Externí odkaz:
https://doaj.org/article/b3bab057419146f7a2a0ab4aaefdc771
Autor:
Olga Solovyeva, Munyaradzi Dimairo, Christopher J. Weir, Siew Wan Hee, Aude Espinasse, Moreno Ursino, Dhrusti Patel, Andrew Kightley, Sarah Hughes, Thomas Jaki, Adrian Mander, Thomas R. Jeffry Evans, Shing Lee, Sally Hopewell, Khadija Rerhou Rantell, An-Wen Chan, Alun Bedding, Richard Stephens, Dawn Richards, Lesley Roberts, John Kirkpatrick, Johann de Bono, Christina Yap
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Background Early phase dose-finding (EPDF) trials are crucial for the development of a new intervention and influence whether it should be investigated in further trials. Guidance exists for clinical trial protocols and completed trial repor
Externí odkaz:
https://doaj.org/article/81ef4cb13be84637b253963b7331df99
Publikováno v:
EClinicalMedicine, Vol 64, Iss , Pp 102228- (2023)
Summary: Background: Traditionally, within dose-finding clinical trials, treatment toxicity and tolerability are assessed by clinicians. Research has shown that clinician reporting may have inadequate inter-rater reliability, poor correlation with pa
Externí odkaz:
https://doaj.org/article/d46e56183f9b41778b772fcbf42f7e54
Autor:
Martin Law, Dominique-Laurent Couturier, Babak Choodari-Oskooei, Phillip Crout, Carrol Gamble, Peter Jacko, Philip Pallmann, Mark Pilling, David S. Robertson, Michael Robling, Matthew R. Sydes, Sofía S. Villar, James Wason, Graham Wheeler, S. Faye Williamson, Christina Yap, Thomas Jaki
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/40c2eed3118c4c9da008c2e610d68b01
Autor:
Brian V Tsu, Rimjhim Agarwal, Nandan S Gokhale, Jessie Kulsuptrakul, Andrew P Ryan, Elizabeth J Fay, Lennice K Castro, Christopher Beierschmitt, Christina Yap, Elizabeth A Turcotte, Sofia E Delgado-Rodriguez, Russell E Vance, Jennifer L Hyde, Ram Savan, Patrick S Mitchell, Matthew D Daugherty
Publikováno v:
PLoS Biology, Vol 21, Iss 6, p e3002144 (2023)
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL protease (3CLpro) encoded by diverse c
Externí odkaz:
https://doaj.org/article/cdf5043f3dfb4817b3329b51ef3b0db4
Autor:
Guillermo Villacampa, Dhrusti Patel, Haiyan Zheng, Jessica McAleese, Jan Rekowski, Olga Solovyeva, Zhulin Yin, Christina Yap
Publikováno v:
EClinicalMedicine, Vol 60, Iss , Pp 102020- (2023)
Summary: Background: The paradigm of early phase dose-finding trials has evolved in recent years. Innovative dose-finding designs and protocols which combine phases I and II are becoming more popular in health research. However, the quality of these
Externí odkaz:
https://doaj.org/article/7c0f5bbeacc64de39037ba47262ab652
Autor:
Sharon B. Love, Fay Cafferty, Claire Snowdon, Karen Carty, Joshua Savage, Philip Pallmann, Lucy McParland, Louise Brown, Lindsey Masters, Francesca Schiavone, Dominic Hague, Stephen Townsend, Claire Amos, Annabelle South, Kate Sturgeon, Ruth Langley, Timothy Maughan, Nicholas James, Emma Hall, Sarah Kernaghan, Judith Bliss, Nick Turner, Andrew Tutt, Christina Yap, Charlotte Firth, Anthony Kong, Hisham Mehanna, Colin Watts, Robert Hills, Ian Thomas, Mhairi Copland, Sue Bell, David Sebag-Montefiore, Robert Jones, Mahesh K. B. Parmar, Matthew R. Sydes
Publikováno v:
Trials, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Late-phase platform protocols (including basket, umbrella, multi-arm multi-stage (MAMS), and master protocols) are generally agreed to be more efficient than traditional two-arm clinical trial designs but are not extensively used.
Externí odkaz:
https://doaj.org/article/f16f51eff76c45b9b2545597e35df8a3
Autor:
James M. S. Wason, Munyaradzi Dimairo, Katie Biggs, Sarah Bowden, Julia Brown, Laura Flight, Jamie Hall, Thomas Jaki, Rachel Lowe, Philip Pallmann, Mark A. Pilling, Claire Snowdon, Matthew R. Sydes, Sofía S. Villar, Christopher J. Weir, Nina Wilson, Christina Yap, Helen Hancock, Rebecca Maier
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Adaptive designs are a class of methods for improving efficiency and patient benefit of clinical trials. Although their use has increased in recent years, research suggests they are not used in many situations where they have potential to br
Externí odkaz:
https://doaj.org/article/22339b16e2cc4f4288ebaef1419f4518