Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Christina Weinigel"'
Autor:
Tran Thi Van Anh, Alilou Mostafa, Zhigang Rao, Simona Pace, Stefan Schwaiger, Christian Kretzer, Veronika Temml, Carsten Giesel, Paul M. Jordan, Rossella Bilancia, Christina Weinigel, Silke Rummler, Birgit Waltenberger, Tran Hung, Antonietta Rossi, Hermann Stuppner, Oliver Werz, Andreas Koeberle
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1629-1647 (2021)
Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction. Lipid mediators orchestrate both the initiation and resolution of inflammation. Switching from pro-inflammatory to pro-resolv
Externí odkaz:
https://doaj.org/article/a137a9aac80f4a9797946a4d4cfeaf30
Autor:
Helmut Pein, Alexia Ville, Simona Pace, Veronika Temml, Ulrike Garscha, Martin Raasch, Khaled Alsabil, Guillaume Viault, Chau-Phi Dinh, David Guilet, Fabiana Troisi, Konstantin Neukirch, Stefanie König, Rosella Bilancia, Birgit Waltenberger, Hermann Stuppner, Maria Wallert, Stefan Lorkowski, Christina Weinigel, Silke Rummler, Marc Birringer, Fiorentina Roviezzo, Lidia Sautebin, Jean-Jacques Helesbeux, Denis Séraphin, Alexander S. Mosig, Daniela Schuster, Antonietta Rossi, Pascal Richomme, Oliver Werz, Andreas Koeberle
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Vitamin E metabolites are proposed to have signalling capacity, but how they may regulate immune responses is still unclear. Here the authors show that a vitamin E metabolite, α-T-13′-COOH, can inhibit 5-lipoxygenase and thereby suppress the synth
Externí odkaz:
https://doaj.org/article/8f5b1e43017943509f14b4b68fe07ec5
Autor:
Simona Pace, Antonietta Rossi, Verena Krauth, Friederike Dehm, Fabiana Troisi, Rossella Bilancia, Christina Weinigel, Silke Rummler, Oliver Werz, Lidia Sautebin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The severity and course of inflammatory processes differ between women and men, but the biochemical mechanisms underlying these sex differences are elusive. Prostaglandins (PG) and leukotrienes (LT) are lipid mediators linked to inflammation
Externí odkaz:
https://doaj.org/article/a60cd34d072d4aff9b194d5994fd68ea
Autor:
Antonietta Rossi, Tran Hung, Oliver Werz, Christina Weinigel, Rossella Bilancia, Birgit Waltenberger, Zhigang Rao, Veronika Temml, Hermann Stuppner, Christian Kretzer, Carsten Giesel, Andreas Koeberle, Stefan Schwaiger, Silke Rummler, Alilou Mostafa, Tran Thi Van Anh, Paul M. Jordan, Simona Pace
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1629-1647 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1629-1647 (2021)
Chronic inflammation results from excessive pro-inflammatory signaling and the failure to resolve the inflammatory reaction. Lipid mediators orchestrate both the initiation and resolution of inflammation. Switching from pro-inflammatory to pro-resolv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37f392110fe92c90644de4ab5824841d
http://europepmc.org/articles/PMC8245855
http://europepmc.org/articles/PMC8245855
Autor:
Simona Pace, Daniela Schuster, Marc Birringer, Maria Wallert, Christina Weinigel, Hermann Stuppner, Denis Séraphin, David Guilet, Veronika Temml, Martin Raasch, Silke Rummler, Helmut Pein, Fiorentina Roviezzo, Jean-Jacques Helesbeux, Rosella Bilancia, Lidia Sautebin, Stefanie König, Guillaume Viault, Chau-Phi Dinh, Alexia Ville, Ulrike Garscha, Birgit Waltenberger, Alexander S. Mosig, Stefan Lorkowski, Andreas Koeberle, Fabiana Troisi, Pascal Richomme, Oliver Werz, Khaled Alsabil, Antonietta Rossi, Konstantin Neukirch
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.3834. ⟨10.1038/s41467-018-06158-5⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.3834. ⟨10.1038/s41467-018-06158-5⟩
Systemic vitamin E metabolites have been proposed as signaling molecules, but their physiological role is unknown. Here we show, by library screening of potential human vitamin E metabolites, that long-chain ω-carboxylates are potent allosteric inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfee7afdff0d4990f14ad8886b080055
http://link.springer.com/article/10.1038/s41467-018-06158-5
http://link.springer.com/article/10.1038/s41467-018-06158-5
Autor:
Gerhard K. E. Scriba, Thea Kleinschmidt, Ulrike Garscha, Christina Weinigel, Jesper Z. Haeggström, Stefanie Liening, Oliver Werz, Silke Rummler
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1861:1605-1613
Cysteinyl leukotrienes (cys-LTs) cause bronchoconstriction in anaphylaxis and asthma. They are formed by 5-lipoxygenase (5-LOX) from arachidonic acid (AA) yielding the unstable leukotriene A4 (LTA4) that is subsequently conjugated with glutathione (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e9e6b2b602e3372739b22ad29802bf
https://doi.org/10.1016/j.bbalip.2016.07.011
https://doi.org/10.1016/j.bbalip.2016.07.011
Autor:
Ulrike Garscha, Oliver Werz, Silke Rummler, Christina Weinigel, Jana Gerstmeier, Olof Rådmark
Publikováno v:
The FASEB Journal. 30:276-285
5-Lipoxygenase (5-LO) catalyzes the initial steps in the biosynthesis of proinflammatory leukotrienes. Upon cell activation, 5-LO translocates to the nuclear membrane where arachidonic acid is transferred by 5-LO-activating protein (FLAP) to 5-LO for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00da839e4d05d046353d0d78a2387b51
https://doi.org/10.1096/fj.15-278010
https://doi.org/10.1096/fj.15-278010
Autor:
Stefan Lorkowski, Saskia Lindner, Ulrike Garscha, Christina Weinigel, Olga Scherer, Silke Rummler, Marten B. Maeß, Oliver Werz
Publikováno v:
Journal of Immunological Methods. 422:118-124
Monocytes are an important constituent of the innate immune system. Therefore, manipulating gene expression of primary human monocytes is a crucial mean to study and characterize the functions of targeted proteins in monocytes. Gene silencing by tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e300800d68de7e3a6c1a9c131c08c8f1
https://doi.org/10.1016/j.jim.2015.04.007
https://doi.org/10.1016/j.jim.2015.04.007
Autor:
Rossella Bilancia, Christina Weinigel, Lidia Sautebin, Fabiana Troisi, Antonietta Rossi, Verena Krauth, Simona Pace, Oliver Werz, Friederike Dehm, Silke Rummler
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Scientific Reports
Scientific Reports
The severity and course of inflammatory processes differ between women and men, but the biochemical mechanisms underlying these sex differences are elusive. Prostaglandins (PG) and leukotrienes (LT) are lipid mediators linked to inflammation. We demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f45d08c33907fdb4bd11e153f1ecaee
https://doi.org/10.1038/s41598-017-03696-8
https://doi.org/10.1038/s41598-017-03696-8
Autor:
Christina Weinigel, Oliver Werz, Dirk Menche, Alexander S. Mosig, Jana Gerstmeier, Rolf Müller, Martin Raasch, Carlo Pergola, Lea Thomas, Silke Rummler, Zhigang Rao
Pharmacological interference with vacuolar-type H(+)-ATPase (V-ATPase), a proton-translocating enzyme involved in protein transport and pH regulation of cell organelles, is considered a potential strategy for cancer therapy. Macrophages are criticall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ae6fd23e06e113aa450dfa0d0f741f
https://hdl.handle.net/10033/620848
https://hdl.handle.net/10033/620848
