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pro vyhledávání: '"Christina W. Olesen"'
Supplementary figure 2: Inhibition of ATM and knockdown of noxa, caspase-9, μ-calpain and cathepsin B. MCF-7 vector (V) and ΔNErbB2 (ΔN) cells were washed free of tetracycline 72 h before the experiment. Cells were exposed to KU-55933 (10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a597788977ff7bb5da257e69c7f6838
https://doi.org/10.1158/1541-7786.22511089
https://doi.org/10.1158/1541-7786.22511089
Supplementary figure 3: Working model. Pathways involved in cisplatin-induced death in MCF-7 breast cancer cells, and their relation to ΔNErbB2 expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29919a1bfdc67b80f4a723bd2afcb067
https://doi.org/10.1158/1541-7786.22511086
https://doi.org/10.1158/1541-7786.22511086
Supplementary figure 1: Effects of cisplatin treatment on expression of ΔNErbB2 and NHE1, and subcellular localization of cytochrome c. MCF-7 vector (V) and ΔNErbB2 (ΔN) cells were washed free of tetracycline 48 h before the experiment, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e9dc4e3558593f84469b3ac87e6fb10
https://doi.org/10.1158/1541-7786.22511092
https://doi.org/10.1158/1541-7786.22511092
Autor:
Rosalie Bateson, Valeria Padovano, Michael J. Caplan, Nikolay Gresko, Kavita Mistry, Giorgia Schena, Christina W. Olesen
Publikováno v:
The FASEB Journal. 33
Autor:
Julie Schnipper, Marc Severin, Isabella Skandorff Pedersen, Christina W. Olesen, Dan Ploug Christensen, Ida Axholm, Stine F. Pedersen, Jens Vogensen, Jakob Hjorth von Stemann, Jacob M. Schrøder
Publikováno v:
Olesen, C W, Vogensen, J, Axholm, I, Severin, M, Schnipper, J, Pedersen, I S, von Stemann, J H, Schrøder, J M, Christensen, D P & Pedersen, S F 2018, ' Trafficking, localization and degradation of the Na +,HCO 3-Co-transporter NBCn1 in kidney and breast epithelial cells ', Scientific Reports, vol. 8, 7435, pp. 1-16 . https://doi.org/10.1038/s41598-018-25059-7
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
The Na+;HCO3− co-transporter NBCn1 (SLC4A7) is a major regulator of intracellular pH yet its trafficking and turnover are essentially unstudied. Here, we used MDCK-II and MCF-7 cells to investigate these processes in epithelial cells. GFP-NBCn1 mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd7e1bbb7fec06ba0938d1337293fcb
https://curis.ku.dk/ws/files/211164707/Trafficking_localization_and_degradation_of_the_Na_HCO3_Co_transporter_NBCn1_in_kidney_and_breast_epithelial_cells.pdf
https://curis.ku.dk/ws/files/211164707/Trafficking_localization_and_degradation_of_the_Na_HCO3_Co_transporter_NBCn1_in_kidney_and_breast_epithelial_cells.pdf
Autor:
Stine F. Pedersen, Ruth Hendus-Altenburger, Birthe B. Kragelund, Elena Papaleo, Christina W. Olesen, Jeff A. Schnell, Elena Pedraz-Cuesta, Jonathan T. S. Hopper, Carol V. Robinson
Publikováno v:
BMC Biology
Hendus-Altenburger, R, Pedraz Cuesta, E, Olesen, C W, Papaleo, E, Schnell, J A, Hopper, J T S, Robinson, C V, Pedersen, S H F & Kragelund, B B 2016, ' The human Na + /H + exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2 ', BMC Biology, vol. 14, 31 . https://doi.org/10.1186/s12915-016-0252-7
Hendus-Altenburger, R, Pedraz Cuesta, E, Olesen, C W, Papaleo, E, Schnell, J A, Hopper, J T S, Robinson, C V, Pedersen, S H F & Kragelund, B B 2016, ' The human Na + /H + exchanger 1 is a membrane scaffold protein for extracellular signal-regulated kinase 2 ', BMC Biology, vol. 14, 31 . https://doi.org/10.1186/s12915-016-0252-7
Background Extracellular signal-regulated kinase 2 (ERK2) is an S/T kinase with more than 200 known substrates, and with critical roles in regulation of cell growth and differentiation and currently no membrane proteins have been linked to ERK2 scaff
Autor:
Jan Christiansen, Elena Pedraz-Cuesta, Christina W. Olesen, Stine F. Pedersen, Nathalie Loebl, Andrej Gorbatenko, Carolina Bianchi, Haraldur Heidar Sigurdsson
Publikováno v:
The Biochemical journal. 473(21)
The Na+–HCO3– cotransporter NBCn1 (SLC4A7) is up-regulated in breast cancer, important for tumor growth, and a single nucleotide polymorphism (SNP), rs4973768, in its 3′ untranslated region (3′UTR) correlates with increased breast cancer risk
Publikováno v:
The FASEB Journal. 29
We previously showed that the Na+,HCO3- cotransporter NBCn1 (SLC4A7) is upregulated in breast cancer, and that cisplatin treatment of breast cancer cells causes pronounced loss of NBCn1 plasma membrane localization. However, essentially nothing is kn
Publikováno v:
Molecular cancer research : MCR. 13(1)
Despite the frequent expression of N-terminally truncated ErbB2 (ΔNErbB2/p95HER2) in breast cancer and its association with Herceptin resistance and poor prognosis, it remains poorly understood how ΔNErbB2 affects chemotherapy-induced cell death. P
Publikováno v:
Frontiers in Physiology
Aarhus University
Gorbatenko, A, Olesen, C W, Bødtkjer, E & Pedersen, S H F 2014, ' Regulation and roles of bicarbonate transporters in cancer ', Frontiers in Physiology, vol. 5, 130 . https://doi.org/10.3389/fphys.2014.00130
Frontiers in Physiology, Vol 5 (2014)
Gorbatenko, A, Olesen, C W, Boedtkjer, E & Pedersen, S H F 2014, ' Regulation and roles of bicarbonate transporters in cancer ', Frontiers in Physiology, vol. 5, 130, pp. 1-15 .
Aarhus University
Gorbatenko, A, Olesen, C W, Bødtkjer, E & Pedersen, S H F 2014, ' Regulation and roles of bicarbonate transporters in cancer ', Frontiers in Physiology, vol. 5, 130 . https://doi.org/10.3389/fphys.2014.00130
Frontiers in Physiology, Vol 5 (2014)
Gorbatenko, A, Olesen, C W, Boedtkjer, E & Pedersen, S H F 2014, ' Regulation and roles of bicarbonate transporters in cancer ', Frontiers in Physiology, vol. 5, 130, pp. 1-15 .
A unifying feature of solid tumors is a markedly altered pH profile compared to normal tissues. This reflects that solid tumors, despite completely different origins, often share several phenotypic properties with implications for intra- and extracel