Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Christina Voelkel‐Johnson"'
Autor:
Kelly R. Misare, Elizabeth A. Ampolini, Hyland C. Gonzalez, Kaitlan A. Sullivan, Xin Li, Camille Miller, Bintou Sosseh, Jaclyn B. Dunne, Christina Voelkel-Johnson, Kacy L. Gordon, Jessica H. Hartman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Polyploid cells contain more than two copies of each chromosome. Polyploidy has important roles in development, evolution, and tissue regeneration/repair, and can arise as a programmed polyploidization event or be triggered by stress. Cancer
Externí odkaz:
https://doaj.org/article/5a58c60f1ad04f77b4fbd7f303a7d381
Autor:
Kelly R. Misare, Elizabeth A. Ampolini, Hyland C. Gonzalez, Kaitlan A. Sullivan, Xin Li, Camille Miller, Bintou Sosseh, Jaclyn B. Dunne, Christina Voelkel-Johnson, Kacy L. Gordon, Jessica H. Hartman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/60ef9e837e9d4b1485b3a0792ebdc7aa
Autor:
Shai White-Gilbertson, Ping Lu, Ikechukwu Esobi, Jing Echesabal-Chen, Patrick J. Mulholland, Monika Gooz, Besim Ogretmen, Alexis Stamatikos, Christina Voelkel-Johnson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Polyploid Giant Cancer Cells (PGCC) are increasingly being recognized as drivers of cancer recurrence. Therapy stress promotes the formation of these cells, which upon stress cessation often successfully generate more aggressive progeny that
Externí odkaz:
https://doaj.org/article/5d19c7a7507b474aa3ac89418fd4a9ad
Autor:
Robert R. Bowers, Maya F. Andrade, Christian M. Jones, Shai White-Gilbertson, Christina Voelkel-Johnson, Joe R. Delaney
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-13 (2022)
Abstract Background Genomic instability and chemoresistance can arise in cancer due to a unique form of plasticity: that of polyploid giant cancer cells (PGCCs). These cells form under the stress of chemotherapy and have higher than diploid chromosom
Externí odkaz:
https://doaj.org/article/54b64f90c5764688a4aa650cce72a63e
Autor:
Shai White‐Gilbertson, Ping Lu, Christian M. Jones, Stephanie Chiodini, Deborah Hurley, Arabinda Das, Joe R. Delaney, James S. Norris, Christina Voelkel‐Johnson
Publikováno v:
Cancer Medicine, Vol 9, Iss 9, Pp 3142-3152 (2020)
Abstract Polyploid giant cancer cells (PGCC) represent a poorly understood, small subpopulation of tumor cells that are increasingly being recognized for their critical role in therapy resistance, metastasis, and cancer recurrence. PGCC have the pote
Externí odkaz:
https://doaj.org/article/d1f6ae005b2e4bb4b8b54ea700442373
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 7, Pp 1225-1235 (2019)
Radiation treatment failure or relapse after initial response to chemotherapy presents significant clinical challenges in cancer patients. Escape from initial courses of treatment can involve reactivation of embryonic developmental stages, with the f
Externí odkaz:
https://doaj.org/article/27616cc3138c4feaa3a4322e7c69541f
Autor:
Brianna Burke, Catherine Eden, Cynthia Perez, Alex Belshoff, Spencer Hart, Lourdes Plaza-Rojas, Michael Delos Reyes, Kushal Prajapati, Christina Voelkel-Johnson, Elizabeth Henry, Gopal Gupta, José Guevara-Patiño
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Inhibitory checkpoint blockade therapy is an immunomodulatory strategy that results in the restoration of T cell functions, and its efficacy depends on the recognition of tumor cells for destruction. Considering the factors at play, one could propose
Externí odkaz:
https://doaj.org/article/70a96232c7254b679693b5705a96ac6d
Autor:
Yuvaraj Sambandam, Sakamuri V. Reddy, Jennifer L. Mulligan, Christina Voelkel-Johnson, Carol L. Wagner
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
Abstract The vitamin D levels in mothers affect the health status of both the mother and breastfeeding infant. Vitamin D deficient mothers’ infants are prone to rickets. While tumor necrosis factor-related apoptosis inducing ligand (TRAIL) has been
Externí odkaz:
https://doaj.org/article/05be34985f264e98862e7a8b84356f84
Autor:
Lu Dai, Karlie Plaisance-Bonstaff, Christina Voelkel-Johnson, Charles D Smith, Besim Ogretmen, Zhiqiang Qin, Chris Parsons
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102314 (2014)
Phosphorylation of sphingosine by sphingosine kinases (SphK1 and SphK2) generates sphingosine-1-phosphate (S1P), a bioactive sphingolipid which promotes cancer cell survival and tumor progression in vivo. We have recently reported that targeting SphK
Externí odkaz:
https://doaj.org/article/30066601daf84329bf6468c14decdbbc
Publikováno v:
Prostate Cancer, Vol 2012 (2012)
Adenoviral gene therapy using the death receptor ligand TRAIL as the therapeutic transgene can be safely administered via intraprostatic injection but has not been evaluated for efficacy in patients. Here we investigated the efficacy of adenoviral TR
Externí odkaz:
https://doaj.org/article/1d693ffe8feb454890ced65a3602577e