Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christina Tysoe"'
Autor:
Christina Tysoe, Leslie K. Williams, Robert Keyzers, Nham T. Nguyen, Chris Tarling, Jacqueline Wicki, Ethan D. Goddard-Borger, Adeleke H. Aguda, Suzanne Perry, Leonard J. Foster, Raymond J. Andersen, Gary D. Brayer, Stephen G. Withers
Publikováno v:
ACS Central Science, Vol 2, Iss 3, Pp 154-161 (2016)
Externí odkaz:
https://doaj.org/article/ba205bf08fcc4bb4a7ca9db931de6034
Autor:
Patrick Weber, Martin Thonhofer, Summer Averill, Gideon J. Davies, Andres Gonzalez Santana, Philipp Müller, Seyed A. Nasseri, Wendy A. Offen, Bettina M. Pabst, Eduard Paschke, Michael Schalli, Ana Torvisco, Marion Tschernutter, Christina Tysoe, Werner Windischhofer, Stephen G. Withers, Andreas Wolfsgruber, Tanja M. Wrodnigg, Arnold E. Stütz
Publikováno v:
Molecules, Vol 25, Iss 17, p 4025 (2020)
Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid β-galactosidase inhibitors were prepared and their inhibitory and pharmacological chaper
Externí odkaz:
https://doaj.org/article/25403e0b400e40b799edabad23624a55
Autor:
Grace E. Kenney, Molly J. McBride, Tai L. Ng, Bo Zhang, J. Martin Bollinger, Anne Marie Crooke, Christina Tysoe, Carsten Krebs, Debangsu Sil, Emily P. Balskus, Amie K. Boal
Publikováno v:
Journal of the American Chemical Society. 142:11818-11828
The alkylating warhead of the pancreatic cancer drug streptozotocin (SZN) contains an N-nitrosourea moiety constructed from Nω-methyl-l-arginine (l-NMA) by the multi-domain metalloenzyme SznF. The enzyme's central heme-oxygenase-like (HO-like) domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da8d74a99f1201a56f8a0eae42686a46
https://doi.org/10.1021/jacs.0c03431
https://doi.org/10.1021/jacs.0c03431
Autor:
Michael Schalli, Seyed A. Nasseri, Werner Windischhofer, Ana Torvisco, Christina Tysoe, Wendy A. Offen, Stephen G. Withers, Patrick Weber, Philipp Müller, Marion Tschernutter, Summer Averill, Eduard Paschke, Andreas Wolfsgruber, Martin Thonhofer, Bettina M. Pabst, Arnold E. Stütz, Tanja M. Wrodnigg, Gideon J. Davies, Andrés G. Santana
Publikováno v:
Molecules
Molecules, Vol 25, Iss 4025, p 4025 (2020)
Volume 25
Issue 17
Molecules, Vol 25, Iss 4025, p 4025 (2020)
Volume 25
Issue 17
Glycosidase inhibitors have shown great potential as pharmacological chaperones for lysosomal storage diseases. In light of this, a series of new cyclopentanoid &beta
galactosidase inhibitors were prepared and their inhibitory and pharmacologica
galactosidase inhibitors were prepared and their inhibitory and pharmacologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a21aebf7315b8edceb182918f2e34f2
https://eprints.whiterose.ac.uk/167565/1/molecules_25_04025_v3.pdf
https://eprints.whiterose.ac.uk/167565/1/molecules_25_04025_v3.pdf
Autor:
E. Dilip de Silva, Ryan M. Centko, Raymond J. Andersen, Stephen G. Withers, Pamoda B. Ratnaweera, Christina Tysoe
Publikováno v:
Phytochemistry Letters. 22:76-80
Three new thiodiketopiperazine derivatives, rostratazine A (1) , rostratazine B (2) and rostratazine C (3) along with exserohilone (4) and boydine A (5) were isolated and identified from the laboratory culture of Setosphaeria rostrata , an endophytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6752f8646cbe30daed8a9ea3c6fb9fc
https://doi.org/10.1016/j.phytol.2017.09.004
https://doi.org/10.1016/j.phytol.2017.09.004
Autor:
Werner Windischhofer, Patrick Weber, Christina Tysoe, Marion Tschernutter, Martin Thonhofer, Bettina M. Pabst, Arnold E. Stütz, Eduard Paschke, Stephen G. Withers, Michael Schalli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3431-3435
N-Functionalized amino(hydroxymethyl)cyclopentanetriols are potent inhibitors of β-d-galactosidases and, for the first time, could be shown to act as pharmacological chaperones for GM1-gangliosidosis-associated lysosomal acid β-galactosidase thus r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed27a0aed1953c4da5db501097ba30ba
https://doi.org/10.1016/j.bmcl.2017.05.086
https://doi.org/10.1016/j.bmcl.2017.05.086
Autor:
René Lebl, Bettina M. Pabst, Marion Tschernutter, Stephen G. Withers, Arnold E. Stütz, Patrick Weber, Eduard Paschke, Michael Schalli, Werner Windischhofer, Martin Thonhofer, Christina Tysoe
Publikováno v:
Carbohydrate Research. 442:31-40
By Morita-Baylis-Hillman reaction of 2,3-O-isopropylidene-D-glyceraldehyde with α,β-unsaturated carbonyl as well as hetero analogous carbonyl compounds such as acrylonitrile, suitable precursors of isofagomine and of 4-epi-isofagomine are available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7d7402ced2e510646f59daf22ad93c
https://doi.org/10.1016/j.carres.2017.03.003
https://doi.org/10.1016/j.carres.2017.03.003
Autor:
Christina Tysoe, Stephen G. Withers, Werner Windischhofer, Roland Fischer, Michael Schalli, Martin Thonhofer, Eduard Paschke, Bettina M. Pabst, Tanja Rappitsch, Marion Tschernutter, Arnold E. Stütz
Publikováno v:
Carbohydrate Research. :15-22
From 1,2;3,4-di-O-isopropylidene-α-D-galactopyranose, a series of highly functionalized (hydroxymethyl)cyclopentanes was easily available. In line with reports by Reymond and Jager on similar structures, these amine containing basic carbasugars are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::998661ff92ab5acdf19688c29b09da0c
https://doi.org/10.1016/j.carres.2017.03.009
https://doi.org/10.1016/j.carres.2017.03.009
Autor:
Roland Fischer, Michael Schalli, Stephen G. Withers, Christina Tysoe, Martin Thonhofer, Andrés G. Santana, Andreas Wolfsgruber, Arnold E. Stütz
Publikováno v:
Carbohydrate Research. :1-9
A series of N-alkyl derivatives of the D-galactosidase inhibitor 1,4-di-epi-validamine featuring lipophilic substituents at position C-5a was prepared and screened for their glycosidase inhibitory properties. Products turned out selective for β-gala
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc0e5b2401c0da8fd29b7f7de47576a
https://doi.org/10.1016/j.carres.2017.01.006
https://doi.org/10.1016/j.carres.2017.01.006
Autor:
Xuejun Zhu, Bennett R. Streit, J. Martin Bollinger, Zhe Rui, Wenjun Zhang, A.J. Mitchell, Amie K. Boal, Bo Zhang, Elizabeth J. Blaesi, Devon Van Cura, Christina Tysoe, Carsten Krebs, Lauren J. Rajakovich
Publikováno v:
Journal of the American Chemical Society, vol 141, iss 37
J Am Chem Soc
J Am Chem Soc
The iron-dependent oxidase UndA cleaves one C3–H bond and the C1–C2 bond of dodecanoic acid to produce 1-undecene and CO(2). A published x-ray crystal structure showed that UndA has a heme-oxygenase-like fold, thus associating it with a structura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16a4e5d47802e82c1a9f3d521c9746e
https://escholarship.org/uc/item/9dx8c9tr
https://escholarship.org/uc/item/9dx8c9tr