Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christina T. Siwak"'
Publikováno v:
CNS Drug Reviews. 5:193-212
Behavioral stimulants have widespread potential application in the treatment of affective disorders, disorders of vigilance, and disorders of sleep. Most behavioral stimulants, however, must be used with extreme caution because of undesirable side ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9b77a8b53f2daaca7f084d16622dc0a
https://doi.org/10.1111/j.1527-3458.1999.tb00100.x
https://doi.org/10.1111/j.1527-3458.1999.tb00100.x
Autor:
Christina T. Siwak, Steven C. Zicker, Elizabeth Head, Carl W. Cotman, Bruce A. Muggenburg, P. Dwight Tapp, Norton W. Milgram, Heather L. Murphey, Candace J. Ikeda-Douglas
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 29:461-469
The present experiment was part of a 3-year longitudinal study examining the effects of age and antioxidant treatment on cognitive decline in beagles. Two size-concept tasks were administered following pretraining on a series of two-choice (six subte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129c060d0537a82f4a4d97afff1580b4
https://doi.org/10.1016/j.pnpbp.2004.12.011
https://doi.org/10.1016/j.pnpbp.2004.12.011
Autor:
Candace J. Ikeda-Douglas, Bruce A. Muggenburg, Carl W. Cotman, Heather L. Murphey, Steven C. Zicker, Norton W. Milgram, Elizabeth Head, Dwight Tapp, Christina T. Siwak
Publikováno v:
Neurobiology of Aging. 26:77-90
The effectiveness of two interventions, dietary fortification with antioxidants and a program of behavioral enrichment, was assessed in a longitudinal study of cognitive aging in beagle dogs. A baseline protocol of cognitive testing was used to selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe865abeaf6ef8a3b778e25030cafae
https://doi.org/10.1016/j.neurobiolaging.2004.02.014
https://doi.org/10.1016/j.neurobiolaging.2004.02.014
Autor:
Christina T. Siwak, Elizabeth Head, Jr-Yuan Chiou, Carl W. Cotman, Fu Qiang Gao, Min-Ying Su, Bruce A. Muggenburg, Norton W. Milgram, P. Dwight Tapp, Sandra E. Black
Publikováno v:
The Journal of Neuroscience. 24:8205-8213
Application of magnetic resonance imaging (MRI) techniques reveals that human brain aging varies across cortical regions. One area particularly sensitive to normal aging is the frontal lobes.In vitroneuropathological studies and behavioral measures i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455a3f02b282abbd0fff05c3506c584a
https://doi.org/10.1523/jneurosci.1339-04.2004
https://doi.org/10.1523/jneurosci.1339-04.2004
Autor:
Candace J. Ikeda-Douglas, Heather L. Murphey, P. Dwight Tapp, Christina T. Siwak, Norton W. Milgram, Carl W. Cotman, Bruce A. Muggenburg, Elizabeth Head
Publikováno v:
Behavioural Brain Research. 153:199-210
The present study examined the effects of age on concept learning in beagle dogs. In experiment one, subjects were tested on a series of 2-choice size discrimination (2CSD) tasks, in which the correct response was to always approach the larger or sma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd1bcaa2aa02f6212965f31536b6a58
https://doi.org/10.1016/j.bbr.2003.12.003
https://doi.org/10.1016/j.bbr.2003.12.003
Publikováno v:
Physiology & Behavior. 75:65-70
A decrease in motor activity is an expected concomitant of normal aging and has been reported in humans and nonhuman mammals. We have previously failed to find age differences in open-field locomotor activity in beagle dogs. We now report an age-asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32828f2fec5def056fb56415cb092ed
https://doi.org/10.1016/s0031-9384(01)00632-1
https://doi.org/10.1016/s0031-9384(01)00632-1
Publikováno v:
Learning & Memory. 8:317-325
Cognitively characterized young and aged beagle dogs were administered six different spontaneous behavior tests, which provided measures of locomotion, exploration, and social interaction. Consistent with our previous findings, we obtained no overall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65a7950325453c3cedb35d59989121fe
https://doi.org/10.1101/lm.41701
https://doi.org/10.1101/lm.41701
Autor:
Philippe Gruet, Frédérique Woehrlé, Bruce A. Muggenburg, Christina T. Siwak, Norton W. Milgram, Heather L. Murphey
Publikováno v:
American Journal of Veterinary Research. 61:1410-1414
Objective—To compare the efficacy of adrafinil, propentofylline, and nicergoline for enhancing behavior of aged dogs. Animals—36 Beagles between 9 and 16 years old. Procedure—Dogs were randomly assigned to receive adrafinil (20 mg/kg of body we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cacd50e0871fbfe648cf159b4607f96
https://doi.org/10.2460/ajvr.2000.61.1410
https://doi.org/10.2460/ajvr.2000.61.1410
Publikováno v:
Progress in Neuro-Psychopharmacology and Biological Psychiatry. 24:709-726
1. Adrafmil is a novel vigilance promoting agent developed in France by Louis Lafon Laboratories. 2. Adrafinil causes increased locomotion without producing stereotypical activity in canines tested in an open field. 3. The effectiveness of a single t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::404a1ec942a93ae6bdd05d2b530b5f8b
https://doi.org/10.1016/s0278-5846(00)00103-2
https://doi.org/10.1016/s0278-5846(00)00103-2
Autor:
Heather L. Murphey, M Schneider, Norton W. Milgram, Christina T. Siwak, Heather Callahan, Bruce A. Muggenburg, P Gruet, F Woehrlé
Publikováno v:
Pharmacology Biochemistry and Behavior. 66:293-300
Adrafinil, a vigilance enhancing pharmaceutical, was administered to aged dogs for 14 consecutive days at doses of 10, 20, 30, or 40 mg/kg using a crossover design. The effects on spontaneous behavior in a 10-min canine open-field test were systemati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c3cbfd89565b648e7b183b297c46ad
https://doi.org/10.1016/s0091-3057(00)00188-x
https://doi.org/10.1016/s0091-3057(00)00188-x