Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Christina Surulescu"'
Publikováno v:
Mathematics in Engineering, Vol 4, Iss 6, Pp 1-28 (2022)
We propose a multiphase modeling approach to describe glioma pseudopalisade patterning under the influence of acidosis. The phases considered at the model onset are glioma, normal tissue, necrotic matter, and interstitial fluid in a void-free volume
Externí odkaz:
https://doaj.org/article/042c015ac0ca41339a5d21c095ba69c8
Autor:
Sven Knobe, Yvonne Dzierma, Michael Wenske, Christian Berdel, Jochen Fleckenstein, Patrick Melchior, Jan Palm, Frank G. Nuesken, Alexander Hunt, Christian Engwer, Christina Surulescu, Umut Yilmaz, Wolfgang Reith, Christian Rübe
Publikováno v:
Zeitschrift für Medizinische Physik, Vol 32, Iss 2, Pp 149-158 (2022)
Glioblastoma (GBM) is one of the most common primary brain tumours in adults, with a dismal prognosis despite aggressive multimodality treatment by a combination of surgery and adjuvant radiochemotherapy. A detailed knowledge of the spreading of glio
Externí odkaz:
https://doaj.org/article/560c9addfd064c7ea8dc34758b37a4f2
Publikováno v:
Mathematical Biosciences and Engineering, Vol 16, Iss 1, Pp 320-337 (2019)
The most aggressive tumor cells, which often reside in a hypoxic environment, can release vast amounts of lactate and protons via monocarboxylate transporters (MCTs). This additional proton efflux exacerbates extracellular acidification and supports
Externí odkaz:
https://doaj.org/article/313f2c39398d48dcb7a8c7d005e3ac4b
Autor:
Pawan Kumar, Christina Surulescu
Publikováno v:
Symmetry, Vol 12, Iss 11, p 1870 (2020)
We propose a model for glioma patterns in a microlocal tumor environment under the influence of acidity, angiogenesis, and tissue anisotropy. The bottom-up model deduction eventually leads to a system of reaction–diffusion–taxis equations for gli
Externí odkaz:
https://doaj.org/article/7ab6e0d5faee4e08a2b091691a8f342c
Publikováno v:
Mathematical Models and Methods in Applied Sciences. 33:1009-1051
A multiscale model for glioma spread in brain tissue under the influence of vascularization and vascular endothelial growth factors is proposed. It accounts for the interplay between the different components of the neoplasm and the healthy tissue and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b33f6431e5219e59b67f5de03a2eed23
https://doi.org/10.1142/s0218202523500227
https://doi.org/10.1142/s0218202523500227
Autor:
Anna Zhigun, Christina Surulescu
Publikováno v:
Zhigun, A & Surulescu, C 2022, ' A novel derivation of rigorous macroscopic limits from a micro-meso description of signal-triggered cell migration in fibrous environments ', SIAM Journal on Applied Mathematics, vol. 82, no. 1 . https://doi.org/10.1137/20M1365442
In this work we upscale a prototypical kinetic transport equation which models a cell population moving in a fibrous environment with a chemo- or haptotactic signal influencing both the direction and the magnitude of the cell velocity. The presented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af95af4b1312e26020eaf6f9422f090
https://doi.org/10.1137/20m1365442
https://doi.org/10.1137/20m1365442
Publikováno v:
Discrete & Continuous Dynamical Systems - B. 26:443-481
We provide a short review of existing models with multiple taxis performed by (at least) one species and consider a new mathematical model for tumor invasion featuring two mutually exclusive cell phenotypes (migrating and proliferating). The migratin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bda5992bbf8eaa79aee592ba44d3ff8
https://doi.org/10.3934/dcdsb.2020284
https://doi.org/10.3934/dcdsb.2020284
Publikováno v:
Journal of Differential Equations. 269:9090-9122
The global boundedness and the hair trigger effect of solutions for the nonlinear nonlocal reaction-diffusion equation ∂ u ∂ t = Δ u + μ u α ( 1 − κ J ⁎ u β ) , in R N × ( 0 , ∞ ) , N ≥ 1 with α ≥ 1 , β , μ , κ > 0 and u ( x ,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1548b2d7b8e4f99f2e7c9d9a43fa167f
https://doi.org/10.1016/j.jde.2020.06.039
https://doi.org/10.1016/j.jde.2020.06.039
Publikováno v:
Neuro-Oncology. 24:vii295-vii295
Gliomas are the most prevalent, aggressive, and invasive subtype of primary brain tumors, characterized by fast cell growth, strong invasion capability, and well-developed tumor vasculature. Although the research advances and the clinical trials test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e2548e78a97976700d60431a02a7188
https://doi.org/10.1093/neuonc/noac209.1150
https://doi.org/10.1093/neuonc/noac209.1150
Publikováno v:
Kumar, P, Surulescu, C & Zhigun, A 2021, ' Multiphase modelling of glioma pseudopalisading under acidosis ', Mathematics in Engineering, vol. 4, no. 6, pp. 1-28 . https://doi.org/10.3934/mine.2022049
We propose a multiphase modeling approach to describe glioma pseudopalisade patterning under the influence of acidosis. The phases considered at the model onset are glioma, normal tissue, necrotic matter, and interstitial fluid in a void-free volume
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5a4b5f767cd64fc8c3fb855dc9bed6
http://arxiv.org/abs/2106.15241
http://arxiv.org/abs/2106.15241
