Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Christina Spry"'
Autor:
Alexa Redway, Christina Spry, Ainka Brown, Ursula Wiedemann, Imam Fathoni, Larnelle F. Garnie, Deyun Qiu, Timothy J. Egan, Adele M. Lehane, Yvette Jackson, Kevin J. Saliba, Nadale Downer-Riley
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 25, Iss , Pp 100536- (2024)
Malaria continues to be a significant burden, particularly in Africa, which accounts for 95% of malaria deaths worldwide. Despite advances in malaria treatments, malaria eradication is hampered by insecticide and antimalarial drug resistance. Consequ
Externí odkaz:
https://doaj.org/article/7c9a9489f8234aad9bd8dd478692ccf0
Autor:
Vanessa M. Howieson, Joy Zeng, Joachim Kloehn, Christina Spry, Chiara Marchetti, Matteo Lunghi, Emmanuel Varesio, Andrew Soper, Anthony G. Coyne, Chris Abell, Giel G. van Dooren, Kevin J. Saliba
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 22, Iss , Pp 1-8 (2023)
Toxoplasma gondii is a pervasive apicomplexan parasite that can cause severe disease and death in immunocompromised individuals and the developing foetus. The treatment of toxoplasmosis often leads to serious side effects and novel drugs and drug tar
Externí odkaz:
https://doaj.org/article/00b024bbf99f4341a185721a0ef4505e
Autor:
Jenni A Hayward, F Victor Makota, Daniela Cihalova, Rachel A Leonard, Esther Rajendran, Soraya M Zwahlen, Laura Shuttleworth, Ursula Wiedemann, Christina Spry, Kevin J Saliba, Alexander G Maier, Giel G van Dooren
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1011987 (2024)
[This corrects the article DOI: 10.1371/journal.ppat.1011517.].
Externí odkaz:
https://doaj.org/article/c192140a1d294373bec4e82a93a0eb00
Autor:
Jenni A Hayward, F Victor Makota, Daniela Cihalova, Rachel A Leonard, Esther Rajendran, Soraya M Zwahlen, Laura Shuttleworth, Ursula Wiedemann, Christina Spry, Kevin J Saliba, Alexander G Maier, Giel G van Dooren
Publikováno v:
PLoS Pathogens, Vol 19, Iss 7, p e1011517 (2023)
Apicomplexans are widespread parasites of humans and other animals, and include the causative agents of malaria (Plasmodium species) and toxoplasmosis (Toxoplasma gondii). Existing anti-apicomplexan therapies are beset with issues around drug resista
Externí odkaz:
https://doaj.org/article/3a72707fe5c84a1cbf9650cd91318ee5
Autor:
Vitor Mendes, Simon R. Green, Joanna C. Evans, Jeannine Hess, Michal Blaszczyk, Christina Spry, Owain Bryant, James Cory-Wright, Daniel S-H. Chan, Pedro H. M. Torres, Zhe Wang, Navid Nahiyaan, Sandra O’Neill, Sebastian Damerow, John Post, Tracy Bayliss, Sasha L. Lynch, Anthony G. Coyne, Peter C. Ray, Chris Abell, Kyu Y. Rhee, Helena I. M. Boshoff, Clifton E. Barry, Valerie Mizrahi, Paul G. Wyatt, Tom L. Blundell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
The bifunctional enzyme CoaBC catalyses the second and third step in the Coenzyme A (CoA) biosynthesis pathway and is of interest as a M. tuberculosis drug target. Here, the authors present the full-length crystal structure of Mycobacterium smegmatis
Externí odkaz:
https://doaj.org/article/dfbd7ac1fa2f42d49910fcdc7940c42e
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009797 (2021)
Coenzyme A is synthesised from pantothenate via five enzyme-mediated steps. The first step is catalysed by pantothenate kinase (PanK). All PanKs characterised to date form homodimers. Many organisms express multiple PanKs. In some cases, these PanKs
Externí odkaz:
https://doaj.org/article/b157da0f67394e19927b74bd0e946384
Autor:
Erick T Tjhin, Christina Spry, Alan L Sewell, Annabelle Hoegl, Leanne Barnard, Anna E Sexton, Ghizal Siddiqui, Vanessa M Howieson, Alexander G Maier, Darren J Creek, Erick Strauss, Rodolfo Marquez, Karine Auclair, Kevin J Saliba
Publikováno v:
PLoS Pathogens, Vol 14, Iss 4, p e1006918 (2018)
The malaria-causing blood stage of Plasmodium falciparum requires extracellular pantothenate for proliferation. The parasite converts pantothenate into coenzyme A (CoA) via five enzymes, the first being a pantothenate kinase (PfPanK). Multiple antipl
Externí odkaz:
https://doaj.org/article/ca8d6cb2b36a471fb52aa4413da7d352
Autor:
Christina Spry, Cristiano Macuamule, Zhiyang Lin, Kristopher G Virga, Richard E Lee, Erick Strauss, Kevin J Saliba
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e54974 (2013)
Growth of the virulent human malaria parasite Plasmodium falciparum is dependent on an extracellular supply of pantothenate (vitamin B(5)) and is susceptible to inhibition by pantothenate analogues that hinder pantothenate utilization. In this study,
Externí odkaz:
https://doaj.org/article/bec1316d7f524a58bec1071ea6c7fda6
Autor:
Jinming Guan, Tanakorn Kittikool, Harriet Ling, Vanessa M. Howieson, Kevin J. Saliba, Karine Auclair, Erick T. Tjhin, Gaetan Burgio, Christina Spry, Lora Starrs, Dustin Duncan, Penghui Yang
Publikováno v:
Journal of Medicinal Chemistry. 64:4478-4497
The Plasmodium parasites that cause malaria are adept at developing resistance to antimalarial drugs, necessitating the search for new antiplasmodials. Although several amide analogs of pantothenate (pantothenamides) show potent antiplasmodial activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb191dfb00ce17d056e455a619564b07
https://doi.org/10.1021/acs.jmedchem.0c01755
https://doi.org/10.1021/acs.jmedchem.0c01755
Autor:
Jenni A. Hayward, F. Victor Makota, Daniela Cihalova, Esther Rajendran, Soraya M. Zwahlen, Laura Shuttleworth, Ursula Wiedemann, Christina Spry, Kevin J. Saliba, Alexander G. Maier, Giel G. van Dooren
With the advent of resistance to existing treatments, new drugs are needed to combat apicomplexan parasites such as the causative agents of malaria (Plasmodium species) and toxoplasmosis (Toxoplasma gondii). To identify new inhibitors of the mitochon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0722cf1d05140c624f0776a8bc9b0245
https://doi.org/10.1101/2022.02.13.480284
https://doi.org/10.1101/2022.02.13.480284
