Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christina Spaulding"'
Autor:
Mario A. Shields, Anastasia E. Metropulos, Christina Spaulding, Khulood A. Alzahrani, Tomonori Hirose, Shigeo Ohno, Thao N.D. Pham, Hidayatullah G. Munshi
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 5, Pp 101389- (2024)
Background & Aims: The apical-basal polarity of pancreatic acinar cells is essential for maintaining tissue architecture. However, the mechanisms by which polarity proteins regulate acinar pancreas injury and regeneration are poorly understood. Metho
Externí odkaz:
https://doaj.org/article/f3ce28d81ae14af7855d183093dd877f
Autor:
Christina Spaulding
Publikováno v:
EXARC Journal, Iss 2023/4 (2023)
As the title implies, Faser Werkstatt: Traditionelle Textiltechnik mit natürlichen Materialien is a direct and practical book on the historical creation and use of fibers. It is aimed at a casual reader with little to no knowledge or experience with
Externí odkaz:
https://doaj.org/article/bd5e2a182216425eab9f96a14fb52ef7
Autor:
Thao N.D. Pham, Christina Spaulding, Mario A. Shields, Anastasia E. Metropulos, Dhavan N. Shah, Mahmoud G. Khalafalla, Daniel R. Principe, David J. Bentrem, Hidayatullah G. Munshi
Publikováno v:
JCI Insight, Vol 7, Iss 9 (2022)
To elicit effective antitumor responses, CD8+ T cells need to infiltrate tumors and sustain their effector function within the immunosuppressive tumor microenvironment (TME). Here, we evaluate the role of MNK activity in regulating CD8+ T cell infilt
Externí odkaz:
https://doaj.org/article/1a09d8a5ba8e4f9fab3e3efe9e16fad1
Autor:
Thao N.D. Pham, Sophie Stempel, Mario A. Shields, Christina Spaulding, Krishan Kumar, David J. Bentrem, Maria Matsangou, Hidayatullah G. Munshi
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4293 (2019)
Bromodomain and extraterminal domain (BET) proteins, which are important epigenetic readers, are often dysregulated in cancer. While a number of BET inhibitors are currently in early phase clinical trials, BET inhibitors show limited single-agent act
Externí odkaz:
https://doaj.org/article/972ecb3f69774d61adfb2ed96fb1fc29
Autor:
Thao D. Pham, Anastasia E. Metropulos, Nida Mubin, Dhavan N. Shah, Christina Spaulding, Mario Shields, David J. Bentrem, Hidayatullah G. Munshi
Publikováno v:
Cancer Research. 83:LB232-LB232
FOLFIRINOX, a chemotherapy regimen consisting of 5FU, Leucovorin, Irinotecan, and Oxaliplatin, has been a first-line standard of care for patients with pancreatic adenocarcinoma (PDAC) for the last decade. However, low patient survival rates followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2090632fa10f8c52349a3db478bfd95
https://doi.org/10.1158/1538-7445.am2023-lb232
https://doi.org/10.1158/1538-7445.am2023-lb232
Autor:
Mario A. Shields, Anastasia E. Metropulos, Christina Spaulding, Thao ND Pham, Hidayatullah G. Munshi
Publikováno v:
Cancer Research. 82:C042-C042
G protein-coupled receptor (GPCR) signaling regulates many aspects of tumor biology, including inflammation, angiogenesis, and metastasis. However, the tumor-specific functions of G proteins, immediate downstream signaling partners of GPCRs, are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::818b8dc428d0492821f641246f51153e
https://doi.org/10.1158/1538-7445.panca22-c042
https://doi.org/10.1158/1538-7445.panca22-c042
Publikováno v:
Journal of the American College of Surgeons. 235:S247-S247
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25e3028dce8e1088ed2fe649c0cb2688
https://doi.org/10.1097/01.xcs.0000894940.82721.a5
https://doi.org/10.1097/01.xcs.0000894940.82721.a5
Gα13 loss promotes tumor progression in the KPC transgenic mouse model of advanced pancreatic cancer
Autor:
Hidayatullah G. Munshi, Christina Spaulding, Mahmoud G. Khalafalla, Thao Pham, Mario A. Shields
SUMMARYGα13 transduces signals from G protein-coupled receptors. Gα13 is pro-tumorigenic in epithelial cancer cell lines, which contrasts with its tumor-suppressive function in transgenic mouse models of lymphomas. Here we show that while loss of G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375c5a5528a095d2748376555aa21822
https://doi.org/10.1101/2021.03.15.435488
https://doi.org/10.1101/2021.03.15.435488
Autor:
Daniel R. Principe, Hidayatullah G. Munshi, Mario A. Shields, Thao Pham, Jose G. Trevino, Bo Li, Patrick W. Underwood, Christina Spaulding, David J. Bentrem
Publikováno v:
Cancers
Cancers, Vol 13, Iss 440, p 440 (2021)
Cancers, Vol 13, Iss 440, p 440 (2021)
Simple Summary Immune checkpoint blockade has provided durable clinical responses in a number of human malignancies, but not in patients with pancreatic cancer. Efforts to understand mechanisms of resistance and increase efficacy of immune checkpoint
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3938cc0d479ea4c3b598d17d0db17a32
https://pubmed.ncbi.nlm.nih.gov/33503832
https://pubmed.ncbi.nlm.nih.gov/33503832
Autor:
Mario A. Shields, Christina Spaulding, Anastasia E. Metropulos, Mahmoud G. Khalafalla, Thao N.D. Pham, Hidayatullah G. Munshi
Publikováno v:
Cell Reports. 38:110441
Gα13 transduces signals from G-protein-coupled receptors. While Gα13 functions as a tumor suppressor in lymphomas, it is not known whether Gα13 is pro-tumorigenic or tumor suppressive in genetically engineered mouse (GEM) models of epithelial canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca934e9573f66f19e8a5c94c65e528a
https://doi.org/10.1016/j.celrep.2022.110441
https://doi.org/10.1016/j.celrep.2022.110441